Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment

Matt, Eva; Dörl, Gregor; Beisteiner, Roland

doi:10.1002/trc2.12245

Cited by 28 publications

(31 citation statements)

References 20 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In conclusion, TPS can be included as an effective and safe add-on treatment for Alzheimer's disease. Even though the first studies (7,9,10), as well as our findings, show promising results, more research is needed, including long-term results in patients. Besides larger sham controlled trials, translational research on the mechanisms of action and effects on cerebral network physiology will be needed.…”

Section: Discussionmentioning

confidence: 67%

“…Diagnostic criteria were assessed according to the NIA-AA criteria. “A” labels biomarker of Aß plaques, “T” labels biomarkers of fibrillar tau, and “N” labels biomarkers of neurodegeneration or neuronal injury ( 10 ). Two patients were included with no biomarkers tested.…”

Section: Methodsmentioning

confidence: 99%

“…This effect lasted up to a 3-month follow-up period. Additionally, a significant improvement of depressive symptoms after 2–4 weeks of TPS treatment was reported, which suggests TPS as an add-on therapy for depression in AD ( 10 ).…”

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

et al. 2022

View full text Add to dashboard Cite

IntroductionTranscranial pulse stimulation (TPS) is a non-invasive neuromodulation therapy that uses short, repetitive shockwaves through a neuro-navigated device. Current research suggests that these pulses lead to a wide range of vascular, metabolic, and neurotrophic changes. This relatively new CE-marked treatment provided first promising results in a clinical pilot study for improving cognition in mild-to-moderate Alzheimer's. Data from other centers is lacking, so here we analyzed safety and pilot real-world short-term results of TPS from the first center in Germany. To gain information about effects in different stages, patients with not only mild but also moderate-to-severe Alzheimer's were analyzed.MethodsA total of 11 patients were retrospectively examined for cognitive and emotional function before and after the first stimulation series. The effect was assessed using several neuropsychological tests [Alzheimer's Disease Assessment Scale (ADAS), including the ADAS cognitive score (ADAS Cog) and ADAS affective scores, Mini-Mental Status Examination (MMSE), and Montreal Cognitive Assessment (MoCA)] including in comparison between the groups of mild-to-severe patients. Moreover, subjective improvement of symptom severity, potential effects on depressive symptoms, and side effects were analyzed using Numeric Rating Scales (NRS).ResultsSide effects were rare (in 4% of sessions) with moderate subjective severity and only transient. Patients significantly improved in the ADAS and ADAS Cog, while there was no significant effect in MMSE and MoCA. Patients' self-reported symptom severity improved significantly. The depressive symptoms measured in an ADAS subscale also improved significantly. Statistical data analyses revealed no significant correlation of clinical improvement with baseline symptom severity.ConclusionTPS might be a safe and promising add-on therapy for Alzheimer's, even for moderate-to-severe patients. More research on long-term effects in patients as well as studies with sham control groups is needed. Moreover, translational research on the mechanisms of action and effects on cerebral network physiology will be needed to understand this new neuromodulation technique.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The novel brain stimulation technique TPS can generate improvements for memory, language, and mood when targeting functionally relevant brain regions [ 7 , 9 ]. In contrast, there was a specific decrease in visuo-constructive test scores while network areas for a VisNW had been omitted during stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…Transcranial pulse stimulation (TPS) has been recently introduced as a novel clinical brain stimulation technique applying navigated ultrashort pressure pulses [ 7 , 8 ]. Stimulation of a broad memory network in a group of patients with Alzheimer’s disease (AD) (including language areas and extended dorsolateral prefrontal cortex) exhibited functional as well as behavioral improvements in memory, language, and mood [ 9 ]. Furthermore, a reduction in cortical atrophy measures (increase of cortical thickness) in central AD network areas after TPS intervention has been shown [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer’s Disease: A Follow-up fMRI Analysis

2022

Self Cite

View full text Add to dashboard Cite

Introduction Transcranial pulse stimulation (TPS) has been recently introduced as a novel clinical brain stimulation technique based on highly focused ultrasound pressure pulses. In a first pilot study on clinical effects of navigated and focused ultrasound neuromodulation, a dichotomy of functional effects was found: patients with Alzheimer’s disease improved cognition and language but deteriorated with visuo-constructive functions. Methods We analyzed changes in functional connectivity measured with functional magnetic resonance imaging (fMRI) using graph analysis of a visuo-constructive network in 18 patients with Alzheimer’s disease. We calculated the network’s global efficiency and tested for correlation with visuo-constructive test scores to explain this dichotomy. Results Important visuo-constructive network nodes were not stimulated in the pilot setting and correspondingly global efficiency of a visuo-constructive network was decreased after TPS therapy, compatible with a natural progress of the disease. A correlation between visuo-constructive scores and changes in global efficiency was found. Conclusion Results argue for a high functional specificity of ultrasound-based neuromodulation with TPS.

show abstract

Ultrasound Neuromodulation as a New Brain Therapy

2023

Self Cite

View full text Add to dashboard Cite

Within the last decade, ultrasound has been “rediscovered” as a technique for brain therapies. Modern technologies allow focusing ultrasound through the human skull for highly focal tissue ablation, clinical neuromodulatory brain stimulation, and targeted focal blood‐brain‐barrier opening. This article gives an overview on the state‐of‐the‐art of the most recent application: ultrasound neuromodulation as a new brain therapy. Although research centers have existed for decades, the first treatment centers were not established until 2020, and clinical applications are spreading rapidly.

show abstract

Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment

Cited by 28 publications

References 20 publications

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer’s Disease: A Follow-up fMRI Analysis

Ultrasound Neuromodulation as a New Brain Therapy

Contact Info

Product

Resources

About