Transcranial Magnetic Stimulation

Krieg, Todd; Mogul, David J.

doi:10.1007/978-1-4614-5227-0_9

Cited by 4 publications

(2 citation statements)

References 134 publications

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“…Other applications of TMS being investigated include rehabilitation [5][6][7][8], brain mapping [9,10], diagnosis of neurological disorders [11][12][13], and treatment of psychiatric illnesses [14][15][16], to name a few. TMS consists of a stimulator which pulses large electrical currents through a conductive coil [17,18]. This creates timevarying magnetic fields which, if placed near a subject's head, can induce electrical fields within the head that can depolarize neurons in the brain [19,20].…”

Section: Introductionmentioning

confidence: 99%

Predicting TMS-induced activation in human neocortex using concurrent TMS/PET, finite element analysis and computational modeling

Arabkheradmand

Krieg

Salinas

et al. 2019

Biomed. Phys. Eng. Express

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Transcranial magnetic stimulation (TMS) is a powerful technique to noninvasively activate neurons in the brain. However, the relationship between TMS-generated electric fields (E-fields) and specific cortical responses is not well understood. The goal of this study was to investigate the relationship between induced E-fields and neocortical activation measured by metabolic responses. Human subject-specific detailed finite element models (FEM) of the head were constructed to calculate the distribution of induced cortical E-field vectors. Positron emission tomography (PET) recordings were made during concurrent TMS application as a measure of cortical activation. A functional model of local circuit connections was developed to study the relationship between applied magnetic fields and neocortical activation and was fitted to experimental data. Sensitivity of interneurons to induced tangential E-fields was over twice as strong as pyramidal neuron sensitivity to induced normal E-fields which may help explain why cortical electrophysiological responses to TMS have specific sensitivities to coil orientation. Furthermore, this study produced an algorithm for predicting electrophysiological responses in human neocortex with high accuracy (>95%) that could provide an invaluable tool for planning of specific regional cortical activation critical in both research and clinical applications.

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Section: Introductionmentioning

confidence: 99%

Predicting TMS-induced activation in human neocortex using concurrent TMS/PET, finite element analysis and computational modeling

Arabkheradmand

Krieg

Salinas

et al. 2019

Biomed. Phys. Eng. Express

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“…These depolarizations can typically be observed through muscle twitches when stimulating the motor areas of the brain and measuring the muscle response using electromyography. Persistent effects can be elicited with repetitive TMS (rTMS) in both an up-and down-regulatory fashion (i.e., facilitating excitatory or inhibitory responses) [4]. The therapeutic potential of TMS has, to a large extent, driven increasing research and interest in the field.…”

Section: Introductionmentioning

confidence: 99%

Computational and experimental analysis of TMS-induced electric field vectors critical to neuronal activation

et al. 2015

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Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

2020

Adv Funct Materials

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Neuromodulation is a clinical tool used for treating chronic neuropathic pain by transmitting controlled physical energy to the pre‐identified neural targets in the central nervous system. Its drug‐free, nonaddictive, and improved targeting characteristics have attracted increasing attention among neuroscience research and clinical practices. This article provides a brief overview of the neuropathic pain and pharmacological routines for treatment, summarizes both the invasive and noninvasive neuromodulation modalities for pain management, and highlights an emerging brain stimulation technology, transcranial focused ultrasound (tFUS), with a focus on ultrasound transducer devices and the achieved neuromodulation effects and applications on pain management. Practical considerations of spatial guidance for tFUS are discussed for clinical applications. The safety of transcranial ultrasound neuromodulation and its future prospectives on pain management are also discussed.

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Transcranial Magnetic Stimulation

Cited by 4 publications

References 134 publications

Predicting TMS-induced activation in human neocortex using concurrent TMS/PET, finite element analysis and computational modeling

Predicting TMS-induced activation in human neocortex using concurrent TMS/PET, finite element analysis and computational modeling

Computational and experimental analysis of TMS-induced electric field vectors critical to neuronal activation

Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

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