Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study

Terraneo, Alberto; Leggio, Lorenzo; Saladini, Marina; Ermani, Mario; Bonci, Antonello; Gallimberti, Luigi

doi:10.1016/j.euroneuro.2015.11.011

Cited by 252 publications

(192 citation statements)

References 45 publications

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“…The data that emerge from this experiment may provide a neurobiological basis for the emerging data that a potentiating form of repetitive transcranial magnetic stimulation (TMS) to the DLPFC ( (Camprodon et al, 2007;Politi et al, 2008;Terraneo et al, 2016), or an attenuating form of TMS to the MPFC (Hanlon et al, 2015) appears to dampen craving among cocaine users. To minimize the impact of the methodological and human subject's factors, we employed an experimental technique that activates the prefrontal cortex (like many task-based studies) without requiring the individual to concentrate on a task.…”

Section: Introductionmentioning

confidence: 93%

“…Most of the rTMS studies to date have applied an LTP-inducing form of TMS to the DLPFC in an effort to decrease craving ( (Bellamoli et al, 2014;Gorelick et al, 2014;Hanlon et al, 2015). The efficacy of TMS to the DLPFC as a tool to decrease craving in cocaine users was first demonstrated by Camprodon and collegues (2007) and recently explored in a large, multi-week trial in Italy (Terraneo et al, 2016). It is not immediately obvious why increasing activity in the DLPFC (an element in the executive control network) would decrease craving (a function typically ascribed to the ventral medial PFC and ventral subcortical areas).…”

Section: Implications For Treatment Development-dorsal Medial and Latmentioning

confidence: 99%

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Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study

Hanlon

Dowdle

Moss

et al. 2016

Neuropsychopharmacol

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The integrity of frontal-striatal circuits is an area of great interest in substance dependence literature, particularly as the field begins to develop neural circuit-specific brain stimulation treatments for these individuals. Prior research indicates that frontal-striatal connectivity is disrupted in chronic cocaine users in a baseline (resting) state. It is unclear, however, if this is also true when these circuits are mobilized by an external source. In this study, we measured the functional and structural integrity of frontal-striatal circuitry involved in limbic arousal and executive control in 36 individuals-18 cocaine-dependent individuals with a history of failed quit attempts and 18 age-matched controls. This was achieved by applying a transcranial magnetic stimulation to the medial prefrontal cortex (Brodmann area 10) and the dorsolateral prefrontal cortex (lateral Brodmann 9) while participants rested in the MRI scanner (TMS/BOLD imaging). Relative to the controls, cocaine users had a lower ventral striatal BOLD response to MPFC stimulation. The dorsal striatal BOLD response to DLPFC stimulation however was not significantly different between the groups. Among controls, DLPFC stimulation led to a reciprocal attenuation of MPFC activity (BA 10), but this pattern did not exist in cocaine users. No relationship was found between regional diffusion metrics and functional activity. Considered together these data suggest that, when engaged, cocaine users can mobilize their executive control system similar to controls, but that the 'set point' for mobilizing their limbic arousal system has been elevated-an interpretation consistent with opponent process theories of addiction.

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Section: Introductionmentioning

confidence: 93%

Section: Implications For Treatment Development-dorsal Medial and Latmentioning

confidence: 99%

Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study

Hanlon

Dowdle

Moss

et al. 2016

Neuropsychopharmacol

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“…This negative finding is especially noteworthy because it indicates that IGD may not, on its own, be robustly associated with important clinical outcomes. As such, it may be premature to invest in management of IGD using the same kinds of approaches taken in response to substance-based addiction disorders, for example with TMS (Meng et al, 2014;Shen et al, 2016;Terraneo et al, 2016). Further, this pattern of findings suggests that more high-quality evidence regarding clinical and behavioral effects is needed before concluding this is a legitimate candidate for inclusion in future revisions of the DSM-5.…”

Section: Discussionmentioning

confidence: 90%

A prospective study of the motivational and health dynamics of Internet Gaming Disorder

Przybylski¹

2018

Preprint

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The American Psychiatric Association has identified Internet Gaming Disorder (IGD) as a potential psychiatric condition and called for research to investigate its etiology, stability, and impacts on health and behavior. The present study recruited 5,777 American adults and applied self-determination theory to examine how motivational factors influence, and are influenced by, IGD and health across a six month period. Following a preregistered analysis plan, results confirmed our hypotheses that IGD criteria are moderately stable and that they and basic psychological need satisfaction have a reciprocal relationship over time. Results also showed need satisfaction promoted health and served as a protective factor against IGD. Contrary to what was hypothesized, results provided no evidence directly linking IGD to health over time. Exploratory analyses suggested that IGD may have indirect effects on health by way of its impact on basic needs. Implications are discussed in terms of existing gaming addiction and motivational frameworks.

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“…Repetitive TMS (rTMS), which utilizes multiple currents, can provide a more lasting modulation (Bellamoli et al 2014). While a number of studies have investigated TMS and shown its treatment potential for SUD, the majority had non-imaging outcome measures, such as craving scores or urine drug screen results (Amiaz et al 2009;Mishra et al 2010;Terraneo et al 2016;Trojak et al 2015). A recent study investigated differences in RFC in control and motivational networks after rTMS in AUD patients and controls.…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 97%

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

Cabrera

Wiers

Lindgren

et al. 2016

J Neuroimmune Pharmacol

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Neuroimaging techniques to measure the function and biochemistry of the human brain such as positron emission tomography (PET), proton magnetic resonance spectroscopy ((1)H MRS), and functional magnetic resonance imaging (fMRI), are powerful tools for assessing neurobiological mechanisms underlying the response to treatments in substance use disorders. Here, we review the neuroimaging literature on pharmacological and behavioral treatment in substance use disorder. We focus on neural effects of medications that reduce craving (e.g., naltrexone, bupropion hydrochloride, baclofen, methadone, varenicline) and that improve cognitive control (e.g., modafinil, N-acetylcysteine), of behavioral treatments for substance use disorders (e.g., cognitive bias modification training, virtual reality, motivational interventions) and neuromodulatory interventions such as neurofeedback and transcranial magnetic stimulation. A consistent finding for the effectiveness of therapeutic interventions identifies the improvement of executive control networks and the dampening of limbic activation, highlighting their values as targets for therapeutic interventions in substance use disorders.

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Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study

Abstract: ISRCTN15823943.

Cited by 252 publications

References 45 publications

Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study

Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study

A prospective study of the motivational and health dynamics of Internet Gaming Disorder

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

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