Transcranial magnetic stimulation in therapy studies: examination of the reliability of “standard” coil positioning by neuronavigation

Herwig, Uwe; Padberg, Frank; Unger, J.; Spitzer, Manfred; Schönfeldt‐Lecuona, Carlos

doi:10.1016/s0006-3223(01)01153-2

Cited by 338 publications

(197 citation statements)

References 6 publications

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“…With one exception, the observed deviations were below 5 mm. The maximally observed deviation was 6.0 mm, which still compares favorably to, e.g., coil placement according to the EEG 10-20 system (12) or relative to the motor representation of finger muscles (13). However, it will depend upon the experimental question if this amount of accuracy is sufficient or not.…”

Section: Discussionmentioning

confidence: 63%

New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study

Moisa

Pohmann

Ewald³

et al. 2008

Magnetic Resonance Imaging

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Purpose:To develop and test a novel method for coil placement in interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) studies. Materials and Methods:Initially, a desired TMS coil position at the subject's head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on five subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the blood oxygenation level-dependent (BOLD) responses to short repetitive TMS (rTMS) trains were assessed using echo-planar imaging (EPI) recordings. Results: :The spatial accuracy of our method is in the range of 2.9 Ϯ 1.3 (SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor-and auditoryrelated brain areas, with the activation in M1 being localized in the hand knob. Conclusion:We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.

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Section: Discussionmentioning

confidence: 63%

New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study

Moisa

Pohmann

Ewald³

et al. 2008

Magnetic Resonance Imaging

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“…However, the original study of the localization produced with standard 5 cm method conducted by Herwig et al (2001a) provides an estimation. The mean coordinates in that report on the y-and z-axis were 17 and 47 (SD ¼ 5,6) compared with the 45 and 35 we used.…”

Section: Discussionmentioning

confidence: 99%

“…This involves the localization of the motor cortical site for optimal stimulation of a hand muscle, usually the abductor pollicis brevis, and then measurement 5 cm anteriorly along the scalp surface ('5 cm method'). However, when the fidelity of this method was evaluated, it localized stimulation to DLPFC (defined as cortical landmarks corresponding to Brodmann area, BA, 9) in only 7 of 22 subjects (Herwig et al, 2001a). An even lower success rate would have been likely if a more modern definition of DLPFC was used based on multiple brains such as that published by Rajkowska et al (Rajkowska and GoldmanRakic, 1995).…”

Section: Introductionmentioning

confidence: 99%

A Randomized Trial of rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression

Fitzgerald

Hoy

McQueen

et al. 2009

Neuropsychopharmacol

332

218

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The aim of this study is to investigate whether repetitive transcranial magnetic stimulation (rTMS) targeted to a specific site in the dorsolateral prefrontal cortex (DLPFC), with a neuro-navigational method based on structural MRI, would be more effective than rTMS applied using the standard localization technique. Fifty-one patients with treatment-resistant depression were randomized to receive a 3-week course (with a potential 1-week extension) of high-frequency (10 Hz) left-sided rTMS. Thirty trains (5 s duration) were applied daily 5 days per week at 100% of the resting motor threshold. Treatment was targeted with either the standard 5 cm technique (n ¼ 27) or using a neuro-navigational approach (n ¼ 24). This involved localizing the scalp location that corresponds to a specific site at the junction of Brodmann areas 46 and 9 in the DLPFC based on each individual subject's MRI scan. There was an overall significant reduction in the Montgomery-Asberg Depression Rating Scale scores over the course of the trial, and a better outcome in the targeted group compared with the standard localization group at 4 weeks (p ¼ 0.02). Significant differences were also found on secondary outcome variables. The use of neuro-navigational methods to target a specific DLPFC site appears to enhance response to rTMS treatment in depression. Further research is required to confirm this in larger samples, or to establish whether an alternate method based on surface anatomy, including measurement from motor cortex, can be substituted for the standard 5 cm method.

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“…Although in most cases not anatomically precise (Herwig et al, 2001), rTMS effects in clinical studies most probably relate to frontal forebrain stimulation (review: eg Padberg and Möller, 2003;Schlaepfer et al, 2003). Consequently, to reliably investigate the underlying neurobiological effects in animal models, the adoption of equivalent stimulation conditions is indispensable.…”

Section: Rtms In Rat Studiesmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

Erhardt

Sillaber

Welt

et al. 2004

Neuropsychopharmacol

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Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic structures, especially in the shell region of the nucleus accumbens. Since the DA system is known to play an important role in reward processes, a withdrawal-associated impairment in mesolimbic DA-mediated transmission could possibly implicate reward deficit and thus enhance vulnerability to drug craving and relapse. We have previously demonstrated that acute repetitive transcranial magnetic stimulation (rTMS) has a modulatory effect on DA release in several areas of the rat brain, including dorsal striatum, hippocampus, and nucleus accumbens shell. In the present study, we investigated the possible use of rTMS as a tool in reestablishing the dysregulated DA secretion observed during withdrawal in morphine-sensitized male Sprague-Dawley rats. Using intracerebral microdialysis, we monitored the effects of acute rTMS (20 Hz) on the intra-accumbal release-patterns of DA in freely moving animals that were subjected to a morphine sensitization scheme for a period of 8 days. We provide first evidence that acute rTMS (20 Hz) is able to increase DA concentration in the shell region of the nucleus accumbens in both control animals and morphinesensitized rats during abstinence. The DA release in morphine-sensitized rats was significantly higher than in controls. rTMS, therefore, might gain a potential therapeutic role in the treatment of dysphoric and anhedonic states during drug withdrawal in humans.

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Transcranial magnetic stimulation in therapy studies: examination of the reliability of “standard” coil positioning by neuronavigation

Cited by 338 publications

References 6 publications

New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study

New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study

A Randomized Trial of rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression

Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

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