Transcranial magnetic stimulation in basic and clinical neuroscience: A comprehensive review of fundamental principles and novel insights

Valero‐Cabré, Antoni; Amengual, Julià L.; Stengel, Chloé; Pascual‐Leone, Álvaro; Coubard, Olivier A.

doi:10.1016/j.neubiorev.2017.10.006

Cited by 288 publications

(220 citation statements)

References 209 publications

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“…Another important finding of the current study is that the rTMS‐induced effect of social pain regulation persisted 30 min after the reappraisal task, as revealed by a more positive valance reported for social vs. physical pain pictures in the active TMS group. This result is consistent with evidence described in previous TMS reviews that the delayed effects of one or two sessions of rTMS last for an average period of 30 min and can extend up to 60 min post stimulation (Thut & Pascual‐Leone, ; Valero‐Cabre et al, ). Further studies will be needed to explore whether the effect persists for longer than 30 minutes, however the current study suggests potential feasibility of applying the rTMS on RVLPFC to relieve social pain in clinical practice.…”

Section: Discussionsupporting

confidence: 92%

“…To overcome this drawback, the current study used repetitive transcranial magnetic stimulation (rTMS) to modulate the neural activation of RVLPFC. Compared to tDCS, rTMS offers more focused electric field and increased effectiveness, which makes it more widely used in clinical practice (Valero‐Cabre, Amengual, Stengel, Pascual‐Leone, & Coubard, ).…”

Section: Introductionmentioning

confidence: 99%

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The right VLPFC and downregulation of social pain: A TMS study

Zhao

Shen

et al. 2019

Human Brain Mapping

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Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regulation in physical‐ and social‐pain conditions using repetitive transcranial magnetic stimulation (rTMS). A total of 60 healthy participants underwent active (n = 30) or sham (n = 30) rTMS over the RVLPFC. Following each TMS session, participants performed a non‐reappraisal and then a reappraisal task to downregulate imagined physical or social pain evoked by pictures. Self‐reported negative emotional ratings and electroencephalogram data were recorded during the emotion regulation task. Participants were then required to rate the valence and arousal of those pictures 30 min after the task. It is found that rTMS‐activated RVLPFC led to reductions in subjective negative feelings and amplitudes of the late positive potential during reappraisal; however, these effects were found exclusively in the social‐pain condition. Participants also reported higher positive valence for socially, compared to physically, painful pictures after 30 min of the task. Behavioral and electrophysiological evidence both supported the functional specificity of RVLPFC in regulation of social pain. The prominent delayed effect of rTMS makes it possible to consider the potential application of rTMS‐VLPFC in clinical practice for social pain relief.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The right VLPFC and downregulation of social pain: A TMS study

Zhao

Shen

et al. 2019

Human Brain Mapping

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“…6 Through a phase II randomized controlled trial (RCT), single-pulse transcranial magnetic stimulation (sTMS) has been identified as an efficacious method in the acute treatment of migraine associated with aura. 8,9 The primary difference between these 2 methods is through the delivery mechanism; tDCS delivers electric currents to the brain tissues through electrodes placed on the scalp, 10 while rTMS uses repeated magnetic pulses to induce electric currents in brain tissue through electromagnetic conduction. This technique is based on the scientific rationale that sTMS can block cortical spreading depression, also known as spreading depolarization, which is assumed to be the source of headache in migraine patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of Non‐invasive Brain Stimulation on Headache Intensity and Frequency of Headache Attacks in Patients With Migraine: A Systematic Review and Meta‐Analysis

Feng

Zhang

et al. 2019

Headache

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Background Non‐invasive brain stimulation (NIBS) techniques such as repetitive transcranial magnetic stimulation (rTMS), as well as transcranial direct current stimulation (tDCS) electrically stimulate the brain and modify brain activity to suppress pain. This method is emerging as a potential clinical intervention against migraine. Objective To quantitatively review the efficacy of rTMS and tDCS in randomized controlled trials (RCTs) in modifying headache intensity and frequency of headache attacks in patients suffering from migraine. Methods We searched 5 databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Scopus for articles from January 2000 to September 2018. Any RCT regarding the efficacy on rTMS and tDCS on patients with migraine, was considered to be included. A random effects meta‐analysis was performed to pool effect sizes of outcomes related to headache intensity or frequency of headache attacks. The methodological quality of the included RCTs was assessed using the Physiotherapy Evidence Database scale. Results Nine RCTs with 276 participants in total (experimental group [EG] = 149; control group [CG] = 127) were included in this review. Five included articles used rTMS (EG = 81; CG = 80), and 4 used tDCS (EG = 68; CG = 47). Meta‐analysis of excitatory primary motor cortex (M1) stimulation showed significant effects on reducing headache intensity in patients with migraine (Hedges' g = −0.94; 95% CI, −1.28 to −0.59; P < .001, I2 = 18.39%) with a large effect size. Meta‐analysis of excitatory M1 stimulation showed significant effects on reducing frequency of headache attacks in patients with migraine, with a large effect size (Hedges' g = −0.88; 95% CI, −1.38 to −0.38; P = .001, I2 = 57.15%). Excitatory dorsolateral prefrontal cortex stimulation showed a significant effect on the headache intensity in patients with migraine (Hedges' g = −1.14; 95% CI, −2.21 to −0.07; P = .04, I2 = 61.86%) with a large effect size. However, reductions of frequency of headache attacks was not significant. Limitations Potential differential effects of rTMS and tDCS, various sham methods, and potential overlapping headache disorders among included subjects may affect the estimation of effect sizes. Conclusion Excitatory NIBS of the M1 is likely to reduce headache intensity and the frequency of headache attacks in patients with migraine.

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“…Alterations of neuronal activity by rTMS at the site of stimulation have been widely reported and are thought to be the result of neuron assemblies being depolarized by TMS‐induced electric currents in brain tissue (Valero‐Cabre, Amengual, Stengel, Pascual‐Leone, & Coubard, ). This way, pyramidal cells within a brain region can be activated directly or indirectly (trans‐synaptic; Kobayashi & Pascual‐Leone, ).…”

Section: Discussionmentioning

confidence: 99%

Modulating functional connectivity between medial frontopolar cortex and amygdala by inhibitory and excitatory transcranial magnetic stimulation

Riedel

Heil

Bender

et al. 2019

Human Brain Mapping

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The prefrontal‐limbic network in the human brain plays a major role in social cognition, especially cognitive control of emotion. The medial frontopolar cortex (mFP; Brodmann Area 10) and the amygdala are part of this network and display correlated neuronal activity in time, as measured by functional magnetic resonance imaging (fMRI). This functional connectivity is dynamic, sensitive to training, and affected in mental disorders. However, the effects of neurostimulation on functional connectivity within this network have not yet been systematically investigated. Here, we investigate the effects of both low‐ and high‐frequency repetitive transcranial magnetic stimulation (rTMS) to the right mFP on functional connectivity between mFP and amygdala, as measured with resting state fMRI (rsfMRI). Three groups of healthy participants received either low‐frequency rTMS (1 Hz; N = 18), sham TMS (1 Hz, subthreshold; N = 18) or high‐frequency rTMS (20 Hz; N = 19). rsfMRI was acquired before and after (separate days). We hypothesized a modulation of functional connectivity in opposite directions compared to sham TMS through adjustment of the stimulation frequency. Groups differed in functional connectivity between mFP and amygdala after stimulation compared to before stimulation (low‐frequency: decrease, high‐frequency: increase). Motion or induced changes in neuronal activity were excluded as confounders. Results show that rTMS is effective for increasing and decreasing functional coherence between prefrontal and limbic regions. This finding is relevant for social and affective neuroscience as well as novel treatment approaches in psychiatry.

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Transcranial magnetic stimulation in basic and clinical neuroscience: A comprehensive review of fundamental principles and novel insights

Cited by 288 publications

References 209 publications

The right VLPFC and downregulation of social pain: A TMS study

The right VLPFC and downregulation of social pain: A TMS study

Effects of Non‐invasive Brain Stimulation on Headache Intensity and Frequency of Headache Attacks in Patients With Migraine: A Systematic Review and Meta‐Analysis

Modulating functional connectivity between medial frontopolar cortex and amygdala by inhibitory and excitatory transcranial magnetic stimulation

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