BACKGROUND
This pilot study aimed to investigate the potential efficacy of non-invasive Bioceramic brain stimulation (BMS) in improving brain connectivity and alleviating symptoms associated with anxiety, depression, and sleep disturbances.
OBJECTIVE
The study enrolled 25 healthy participants who underwent BMS and completed anxiety, depression, and sleep quality questionnaires before and after the intervention. Standard preprocessing techniques were applied to the resting-state fMRI data collected from the participants.
METHODS
Functional connectivity analyses were conducted to analyze the data and examine the effects of BMS on brain connectivity.
RESULTS
Following the administration of BMS, significant improvements were observed in anxiety, depression, and sleep quality scores among the participants. Furthermore, enhanced functional connectivity was identified within the default mode network, as well as between different brain regions associated with emotional regulation, sensory processing, and cognitive control.
CONCLUSIONS
The findings of this study provide preliminary evidence supporting the potential efficacy of BMS as a non-invasive technique for brain stimulation. The observed improvements in symptoms and enhanced functional connectivity suggest that BMS may hold promise for the treatment of neurological and emotional disorders.
CLINICALTRIAL
The study was conducted at the Taoyuan General Hospital in Taiwan, and the research protocol involving human subjects was approved by the Medical Ethics and Institutional Review Board of the Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan (Approval No.: TYGH106015).