Transcranial Laser Therapy Attenuates Amyloid-β Peptide Neuropathology in Amyloid-β Protein Precursor Transgenic Mice

Abstract

Transcranial laser therapy (TLT) was tested for efficacy in a mouse model of Alzheimer's disease (AD) using a near-infrared energy laser system. TLT is thought to stimulate ATP production, increase mitochondrial activity, and help maintain neuronal function. Studies were performed to determine the effect of TLT in an amyloid-β protein precursor (AβPP) transgenic mouse model. TLT was administered 3 times/week at various doses, starting at 3 months of age, and was compared to a control group (no laser treatment). Treatment was continued for a total of six months. Animals were examined for amyloid load, inflammatory markers, brain amyloid-β (Aβ) levels, plasma Aβ levels, cerebrospinal fluid Aβ levels, soluble AβPP (sAβPP) levels, and behavioral changes. The numbers of Aβ plaques were significantly reduced in the brain with administration of TLT in a dose-dependent fashion. Administration of TLT was associated with a dose-dependent reduction in amyloid load. All TLT doses mitigated the behavioral effects seen with advanced amyloid deposition and reduce the expression of inflammatory markers in the AβPP transgenic mice. All TLT doses produced an increase in sAβPPα and a decrease in CTFβ levels consistent with inhibition of the β-secretase activity. In addition, TLT showed an increase in ATP levels, mitochondrial function, and c-fos suggesting an overall improvement in neurological function. These studies suggest that TLT is a potential candidate for treatment of AD.

Transcranial Low-Level Laser Therapy for Depression and Alzheimer’s Disease

“…They found that LLLT treatment decreases Aβ plaques and the expression of inflammatory markers in the AβPP transgenic mice [10]. In addition, LLLT treatment showed an increase in ATP levels, mitochondrial function, and c-fos, which result in an overall improvement in neurological function [10]. The data suggest that LLLT is a potential candidate for treatment of AD.…”

“…De Taboada et al tested whether LLLT plays an anti-inflammation role in an Aβ protein precursor (AβPP) transgenic mouse model, a mouse model of AD [10]. They found that LLLT treatment decreases Aβ plaques and the expression of inflammatory markers in the AβPP transgenic mice [10]. In addition, LLLT treatment showed an increase in ATP levels, mitochondrial function, and c-fos, which result in an overall improvement in neurological function [10].…”

“…De Taboada et al tested whether LLLT plays an anti-inflammation role in an Aβ protein precursor (AβPP) transgenic mouse model, a mouse model of AD [10]. They found that LLLT treatment decreases Aβ plaques and the expression of inflammatory markers in the AβPP transgenic mice [10].…”

“…Recently, researchers have shifted the focus of research to the application of LLLT on brain disorders [1][2][3]. During the past decade, LLLT has been widely used to study neurological and psychological diseases [3] such as depressionlike behaviors [4][5][6][7][8], Alzheimer's disease (AD) [9][10][11][12][13][14][15][16][17][18][19][20], Parkinson's disease [21], stroke [22,23] and traumatic brain injury (TBI) [24][25][26][27][28][29][30][31][32]. Because red or NIR light can effectively penetrate into brain tissues [33,34], it can be noninvasive and play a beneficial role in increasing ATP biosynthesis and neurogenesis [1,2].…”

Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade

“…Esta terapia vem crescendo no campo do derrame cerebral (170,171) , injuria traumática do cérebro (172)(173)(174) , doenças neurodegenerativas (175) , e lesões de medula espinal (176) .…”