Transcranial direct current stimulation (tDCS) priming of 1Hz repetitive transcranial magnetic stimulation (rTMS) modulates experimental pain thresholds

Moloney, Tonya M.; Witney, Alice G.

doi:10.1016/j.neulet.2012.11.049

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…The present study reinforces the results of our previous work [18], in providing new evidence for the modulation of pressure pain thresholds using tDCS-primed 1 Hz-rTMS. However using the modality of pressure pain as an index and the same neurostimulation intervention, an increase in thresholds was seen post anodal and cathodal primed 1 Hz-rTMS, with significance present only for cathodal effects.…”

Section: Discussionsupporting

confidence: 91%

“…Previous work revealed that tDCS-primed 1 Hz-rTMS can be applied to enhance the modulation of experimental thermal pain thresholds [18]. Inhibitory preconditioning via cathodal tDCS successfully produced increased thermal pain thresholds after subsequent stimulation of 1 Hz rTMS, simulating the physiological effects of high frequency rTMS whilst being a better tolerated method of intervention.…”

Section: Introductionmentioning

confidence: 99%

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Pressure Pain Thresholds Increase after Preconditioning 1 Hz Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation

Moloney

Witney

2014

PLoS ONE

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BackgroundThe primary motor cortex (M1) is an effective target of non-invasive cortical stimulation (NICS) for pain threshold modulation. It has been suggested that the initial level of cortical excitability of M1 plays a key role in the plastic effects of NICS.ObjectiveHere we investigate whether transcranial direct current stimulation (tDCS) primed 1 Hz repetitive transcranial magnetic stimulation (rTMS) modulates experimental pressure pain thresholds and if this is related to observed alterations in cortical excitability.Method15 healthy, male participants received 10 min 1 mA anodal, cathodal and sham tDCS to the left M1 before 15 min 1 Hz rTMS in separate sessions over a period of 3 weeks. Motor cortical excitability was recorded at baseline, post-tDCS priming and post-rTMS through recording motor evoked potentials (MEPs) from right FDI muscle. Pressure pain thresholds were determined by quantitative sensory testing (QST) through a computerized algometer, on the palmar thenar of the right hand pre- and post-stimulation.ResultsCathodal tDCS-primed 1 Hz-rTMS was found to reverse the expected suppressive effect of 1 Hz rTMS on cortical excitability; leading to an overall increase in activity (p<0.001) with a parallel increase in pressure pain thresholds (p<0.01). In contrast, anodal tDCS-primed 1 Hz-rTMS resulted in a corresponding decrease in cortical excitability (p<0.05), with no significant effect on pressure pain.ConclusionThis study demonstrates that priming the M1 before stimulation of 1 Hz-rTMS modulates experimental pressure pain thresholds in a safe and controlled manner, producing a form of analgesia.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Pressure Pain Thresholds Increase after Preconditioning 1 Hz Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation

Moloney

Witney

2014

PLoS ONE

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“…The study found that cathodal and anodal tDCS increases and decreases the subsequent effects on corticospinal excitability, independently. Similar priming effects occurred when tDCS was followed by repetitive TMS (Siebner et al, 2004; Cosentino et al, 2012; Moloney and Witney, 2013). Furthermore, no adverse effects on neuropsychological function was found after repeated sessions of combined tDCS-rTMS stimulation (Loo et al, 2009).…”

Section: Tdcs Combined With Other Techniquesmentioning

confidence: 65%

Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns

et al. 2017

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Transcranial direct current stimulation (tDCS) is a widely-used tool to induce neuroplasticity and modulate cortical function by applying weak direct current over the scalp. In this review, we first introduce the underlying mechanism of action, the brief history from discovery to clinical scientific research, electrode positioning and montages, and parameter setup of tDCS. Then, we review tDCS application in clinical samples including people with drug addiction, major depression disorder, Alzheimer's disease, as well as in children. This review covers the typical characteristics and the underlying neural mechanisms of tDCS treatment in such studies. This is followed by a discussion of safety, especially when the current intensity is increased or the stimulation duration is prolonged. Given such concerns, we provide detailed suggestions regarding safety procedures for tDCS operation. Lastly, future research directions are discussed. They include foci on the development of multi-tech combination with tDCS such as with TMS and fMRI; long-term behavioral and morphological changes; possible applications in other research domains, and more animal research to deepen the understanding of the biological and physiological mechanisms of tDCS stimulation.

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“…These results suggest that capsaicin and mustard oil have a potential effect on reducing the symptoms of BMS. Systemic SSRIs, zinc replacement therapy, alpha-lipoic acid and aloe vera, hormone replacement treatment, cognitive behavior therapy, and acupuncture may also be effective in reducing BMS symptoms in the short term [78][79][80][81][82][83]. Unfortunately, there is no solid evidence based on basic research to explore the mechanisms of these therapies for BMS.…”

Section: Development Of Treatment For Primary Bmsmentioning

confidence: 99%

A perspective from experimental studies of burning mouth syndrome

et al. 2020

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Burning mouth syndrome (BMS) is one of the most frequently seen idiopathic pain conditions in a dental setting. Peri-and postmenopausal women are most frequently affected, and patients who experience BMS complain of persistent burning pain mainly at the tip and the bilateral border of the tongue. Recent studies have assessed whether BMS is a neuropathic pain condition, based on morphologic changes in biopsied tongue specimens, and whether there are abnormal pain responses in patients with this disease. Somatosensory studies have reported some abnormal findings in sensory and pain detection thresholds with inconsistency; however, the most distinct finding was exaggerated responses to painful stimuli. Imaging and electrophysiologic studies have suggested the possibility of dysregulation of the pain-modulating system in the central nervous system, which may explain the enhanced pain responses despite the lack of typical responses toward quantitative sensory tests. Basic studies have suggested the possible involvement of neuroprotective steroids, although the underlying mechanisms of this condition have not been elucidated. Experimental studies are looking for preferable supportive therapies for BMS patients despite the obscure pathogenesis.

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Transcranial direct current stimulation (tDCS) priming of 1Hz repetitive transcranial magnetic stimulation (rTMS) modulates experimental pain thresholds

Cited by 16 publications

References 27 publications

Pressure Pain Thresholds Increase after Preconditioning 1 Hz Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation

Pressure Pain Thresholds Increase after Preconditioning 1 Hz Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation

Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns

A perspective from experimental studies of burning mouth syndrome

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