Transcranial direct current stimulation: State of the art 2008

Nitsche, Michael A.; Cohen, Leonardo G.; Wassermann, Eric M.; Priori, Alberto; Lang, N.; Antal, Andrea; Paulus, Walter; Hummel, Friedhelm; Boggio, Paulo S.; Fregni, Felipe; Pascual‐Leone, Álvaro

doi:10.1016/j.brs.2008.06.004

Cited by 2,644 publications

(2,328 citation statements)

References 113 publications

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“…tDCS was chosen as it can modulate intrinsic neuronal activity using a weak, constant electrical current (Nitsche et al., 2008) to facilitate cognitive processing including learning and memory (Asthana et al., 2013; Coffman, Clark, & Parasuraman, 2014; Mungee et al., 2014). This work aligns with the rapidly growing body of research that indicates tDCS may have beneficial effects for psychiatric conditions associated with altered prefrontal activity or connectivity, including depression (Drevets, Price, & Furey, 2008), schizophrenia (Meyer‐Lindenberg et al., 2002), and obsessive–compulsive disorder (Chamberlain et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation may modulate extinction memory in posttraumatic stress disorder

et al. 2017

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BackgroundAbnormalities in fear extinction and recall are core components of posttraumatic stress disorder (PTSD). Data from animal and human studies point to a role of the ventromedial prefrontal cortex (vmPFC) in extinction learning and subsequent retention of extinction memories. Given the increasing interest in developing noninvasive brain stimulation protocols for psychopathology treatment, we piloted whether transcranial direct current stimulation (tDCS) during extinction learning, vs. during consolidation of extinction learning, might improve extinction recall in veterans with warzone‐related PTSD.MethodsTwenty‐eight veterans with PTSD completed a 2‐day Pavlovian fear conditioning, extinction, and recall paradigm. Participants received one 10‐min session of 2 mA anodal tDCS over AF3, intended to target the vmPFC. Fourteen received tDCS that started simultaneously with extinction learning onset, and the remaining 14 participants received tDCS during extinction consolidation. Normalized skin conductance reactivity (SCR) was the primary outcome measure. Linear mixed effects models were used to test for effects of tDCS on late extinction and early extinction recall 24 hr later.ResultsDuring early recall, veterans who received tDCS during extinction consolidation showed slightly lower SCR in response to previously extinguished stimuli as compared to veterans who received tDCS simultaneous with extinction learning (p = .08), generating a medium effect size (Cohen's d = .38). There was no significant effect of tDCS on SCR during late extinction.ConclusionsThese preliminary findings suggest that testing the effects of tDCS during consolidation of fear extinction may have promise as a way of enhancing extinction recall.

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Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation may modulate extinction memory in posttraumatic stress disorder

et al. 2017

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“…This reorganisation, or neuroplasticity, is mediated, at least in part, by activity or use-dependent processes that involve synaptic modification inducing either long-term potentiation (LTP) or long-term depression (LTD) of synapses (Sanes and Donoghue 2000). As well as the brain reorganization that occurs in response to activity or use (use-dependent neuroplasticity), there is good evidence to suggest that non-invasive brain stimulation (NIBS) also induces similar neuroplastic changes in the central nervous system, at least for a short period of time (<1hr) (Nitsche et al 2008). …”

Section: Introductionmentioning

confidence: 99%

“…tDCS is thought to induce shifts in transmembrane neuronal potentials and, thus, influence corticospinal excitability (Nitsche et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Fujiyama

Hinder

Barzideh

et al. 2017

Neurobiology of Aging

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Functional motor declines that often occur with advancing age -including reduced efficacy to learn new skills -can have a substantial impact on the quality of life. Recent studies using non-invasive brain stimulation indicate that priming the corticospinal system by lowering the threshold for the induction of long-term potentiation (LTP)-like plasticity before skill training may facilitate subsequent skill learning. Here we utilized 'priming' protocol, in which we used transcranial direct current stimulation (tDCS) applying the cathode over the primary motor cortex (M1) prior to the anode placed over M1 during unimanual isometric force control training (FORCEtraining). Older individuals who received tDCS with the cathode placed over M1 prior to tDCS with the anode placed over M1 concurrent with FORCEtraining showed greater skill improvement and corticospinal excitability increases following the tDCS/FORCEtraining protocol compared to both young and older individuals who did not receive the preceding tDCS with the cathode placed over M1. The results suggested that priming tDCS protocols may be used in clinical settings to improve motor function and thus maintain the functional independence of older adults.

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“…If modulation of physiological processes results in functional alterations, a causal relationship can be assumed. In the last years, a couple of such stimulation protocols have become available, allowing non-invasive modulation of brain activity and excitability, and thus are principally suited to serve this aim [12][13][14][15] . In this review, we give an overview of the principal mechanisms of the tools, and their applications for the exploration of prefrontal functions.…”

Section: Introductionmentioning

confidence: 99%

Exploring prefrontal cortex functions in healthy humans by transcranial electrical stimulation

Kuo

Nitsche²

2015

Neurosci. Bull.

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The prefrontal cortex is involved in a multitude of cognitive, emotional, motivational, and social processes, so exploring its specifi c functions is crucial for understanding human experience and behavior. Functional imaging approaches have largely contributed to the enhancement of our understanding, but might have limitations in establishing causal relationships between physiology and the related psychological and behavioral processes. Non-invasive electrical stimulation with direct or alternating currents can help to enhance our understanding with regard to specific processes, and might provide future protocols able to improve them in case of malfunctions. We review the current state of the fi eld, and provide an outlook for future developments.

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Transcranial direct current stimulation: State of the art 2008

Cited by 2,644 publications

References 113 publications

Transcranial direct current stimulation may modulate extinction memory in posttraumatic stress disorder

Transcranial direct current stimulation may modulate extinction memory in posttraumatic stress disorder

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Exploring prefrontal cortex functions in healthy humans by transcranial electrical stimulation

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