Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus

Cambiaghi, Marco; Buffelli, Mario Rosario; Masin, Laura; Valtorta, Flavia; Comai, Stefano

doi:10.1016/j.brs.2020.01.012

Cited by 12 publications

(8 citation statements)

References 10 publications

(15 reference statements)

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“…Parts of effects on brain region such as nucleus of the thalamus, other than the stimulated region, may also show asymmetry ( Marquez-Ruiz et al, 2012 ). Recently, it has been demonstrated that not only anodal but also cathodal tDCS inhibit dorsal raphe nuclei 5-HT neurons through the activation of neurons in the prelimbic cortex, which is a stimulated region in mice ( Cambiaghi et al, 2020 ). A meta-analysis showed that homogeneity/heterogeneity of tDCS effects depends on the target region.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex

et al. 2020

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Transcranial direct current stimulation (tDCS) is a non-invasive technique that modulates the neuronal membrane potential. We have previously documented a sustainable increase in extracellular dopamine levels in the rat striatum of cathodal tDCS, suggesting that cathodal tDCS enhances the neuronal excitability of the cortex. In the present study, we investigated changes in neuronal activity in the cerebral cortex induced by tDCS at the point beneath the stimulus electrode in anesthetized rats in vivo . Multiunit recordings were performed to examine changes in neuronal activity before and after the application of tDCS. In the cathodal tDCS group, multiunit activity (indicating the collective firing rate of recorded neuronal populations) increased in the cerebral cortex. Both anodal and cathodal tDCS increased the firing rate of isolated single units in the cerebral cortex. Significant differences in activity were observed immediately following stimulation and persisted for more than an hour after stimulation. The primary finding of this study was that both anodal and cathodal tDCS increased in vivo neuronal activity in the rat cerebral cortex underneath the stimulus electrode.

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Section: Discussionmentioning

confidence: 99%

Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex

et al. 2020

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“…Furthermore, the antidepressant effects of tDCS may occur through direct or indirect regulation of DRN 5-HT neurons. A study in 2020 established that an acute cathode of tDCS induces the activation of prolactin cortical neurons and the inhibition of DRN 5-HT neurons, the amplitude of which are higher than that of acute tDCS of the same intensity (Cambiaghi et al, 2020 ). All the mechanisms of tDCS make it an ideal therapeutic approach for treating PPD.…”

Section: Discussionmentioning

confidence: 99%

Effect of transcranial direct current stimulation on postpartum depression: A study protocol for a randomized controlled trial

Sun

Kang²,

Dong³

et al. 2023

Front. Psychol.

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Postpartum depression (PPD) is a complex combination of physiological, emotional, and behavioral alterations associated with postpartum chemical, social, and psychological variations. It does harm to the relationship between family members that could potentially last for years. However, standard depression treatments are not ideal for PPD, and the outcomes of these treatments are debatable. Transcranial direct current stimulation (tDCS) is an emerging technology that could provide patients with PPD with a safe and non-pharmacological treatment. tDCS can relieve depression by directly stimulating the prefrontal cortex through the excitatory effect of the anode. It may also ease depression indirectly by promoting the production and release of the neurotransmitter GABA. The mechanism of tDCS makes it an ideal therapeutic approach to treat PPD, although it has not been widely used, and its effect has not been evaluated systematically and effectively. A double-blind, randomized controlled trial will be conducted involving 240 tDCS-naive patients with PPD, who will be randomly divided into two groups. One group will receive routine clinical treatment and care with active tDCS, and the other group will receive routine clinical treatment and care with sham tDCS. Each group of patients will receive a 3-week intervention during which they will receive 20 min of active or sham tDCS 6 days per week. The Montgomery–Åsberg Depression Rating Scale will be administered before the intervention as a baseline and on each weekend throughout the intervention phase. Before and after the intervention, the Perceived Stress Scale and the Positive and Negative Affect Schedule will be evaluated. Side effects and abnormal reactions will be recorded during each treatment. As antidepressants are banned in the study, the results will not be affected by drugs and will therefore be more accurate. Nonetheless, this experiment will be conducted in a single center as a small sample experiment. Therefore, future studies are required to confirm the effectiveness of tDCS in treating PPD.

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“… 86 Likewise, there is good evidence from both animal and human studies for the strong involvement of the serotonin system in the antidepressant effect of tDCS on the DLPFC. 87 88 More importantly for AD, there are accumulating data suggesting the pivotal role of the cholinergic neurons and their synaptic modulation in the changes induced by tDCS. 85 89 90 Neurophysiological studies in animals have shown that cholinergic modulation facilitates long-term potentiation.…”

Section: The Need For Mechanistic Insightmentioning

confidence: 99%

Potential of Transcranial Direct Current Stimulation in Alzheimer’s Disease: Optimizing Trials Toward Clinical Use

et al. 2022

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Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive method for stimulating the brain that is rapidly developing into a treatment method for various neurological and psychiatric conditions. In particular, there is growing evidence of a therapeutic role for tDCS in ameliorating or delaying the cognitive decline in Alzheimer’s disease (AD). We provide a brief overview of the current development and application status of tDCS as a nonpharmacological therapeutic method for AD and mild cognitive impairment (MCI), summarize the levels of evidence, and identify the improvements needed for clinical applications. We also suggest future directions for large-scale controlled clinical trials of tDCS in AD and MCI, and emphasize the necessity of identifying the mechanistic targets to facilitate clinical applications.

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Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus

Cited by 12 publications

References 10 publications

Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex

Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex

Effect of transcranial direct current stimulation on postpartum depression: A study protocol for a randomized controlled trial

Potential of Transcranial Direct Current Stimulation in Alzheimer’s Disease: Optimizing Trials Toward Clinical Use

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