Transcranial direct current stimulation of the frontal-parietal-temporal brain areas reduces cigarette consumption in abstinent heroin users

Meng, Zhiqiang; Li, Qing; Ma, Yuanye; Liu, Chang

doi:10.1016/j.jpsychires.2022.06.045

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Taken together, the present study adds evidence to the neuromodulation clinical trials in addiction by combining: (i) The use of tDCS paired with cognitive training to engage executive control during the stimulation session; (ii) Tracking relapse outcome over a 4-month follow-up period, longer than follow-up periods in previous clinical trials [3,40]; (iii) Collecting pre-and post-tDCS resting fMRI data, and (iv) Using CDA to determine the directionality of the standard correlational associations to be able to draw causal associations [35] between the stimulation site (LDLPFC) and theoretically defined addiction networks known to support abstinence [14,16].…”

Section: Effect Of Dlpfc Stimulation On Rsfcmentioning

confidence: 92%

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Camchong

Fiecas

Gilmore

et al. 2022

Preprint

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BackgroundBrain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Neuroimaging evidence suggests higher fronto-striatal connectivity as well as higher within-network connectivity of theoretically defined addiction networks is associated with reduced relapse rates and extended abstinence during follow-up periods.Objective/HypothesisA longitudinal randomized double-blind sham-controlled clinical trial investigated whether a non-invasive neuromodulation intervention delivered during early abstinence can (i) modulate connectivity of addiction networks supporting abstinence and (ii) improve relapse rates. Hypotheses: Active transcranial direct current stimulation (tDCS) will (i) increase connectivity of addiction networks known to support abstinence and (ii) reduce relapse rates.MethodsShort-term abstinent AUD participants (n=60) were assigned to 5 days of either active tDCS or sham during cognitive training. Causal discovery analysis (CDA) examined the directional influence from left dorsolateral prefrontal cortex (LDLPFC, stimulation site) to addiction networks that support abstinence.ResultsActive tDCS had an effect on the average strength of CDA-determined connectivity from LDLPFC to the incentive salience and negative emotionality addiction networks - increasing in the active tDCS group and decreasing in the sham group. Active tDCS had an effect on relapse rates 1-month following the intervention, with lower probability of relapse in the active tDCS vs. sham groups. Active tDCS showed an unexpected sex-dependent effect on relapse rates.ConclusionOur results suggest that LDLPFC stimulation delivered during early abstinence has an effect on addiction networks supporting abstinence and on relapse rates. The unexpected sex-dependent neuromodulation effects need to be further examined in larger clinical trials.

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Section: Effect Of Dlpfc Stimulation On Rsfcmentioning

confidence: 92%

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Camchong

Fiecas

Gilmore

et al. 2022

Preprint

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“…DCS can potentially change addictive behavior via modulation of PFC excitability. A growing body of research has shown that tDCS over DLPFC has been found to modulate the consumption of and cravings for cigarettes (Meng et al, 2022), alcohol), tobacco (Fecteau et al, 2014), marijuana (Boggio et al, 2010) and has shown beneficial effects for modulation of addictive behavior and substance dependence (Batista et al, 2015;Hone-Blanchet et al, 2015;Shahbabaie et al, 2014). For instance, Batista et al, (2015), conducted a randomized double-blind sham-controlled study to investigate the effects of bilateral tDCS over DLPFC (left cathodal/right anodal) on carvings, in patients with crackcocaine dependence.…”

Section: Tdcs and Drug Cravingmentioning

confidence: 99%

Rehabilitation implications of new tDCS, aerobic exercise, and impulsivity in drug addiction and drug use disorders

Milshteyn

2023

ajeb

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Addictions and substance use disorders are among the most prevalent mental health disorders attributable globally to higher rates of death per year. Despite multiple available treatment approaches to treat addiction, including pharmacological, psycho-education, 12-Step program, cognitive-behavioral (CBT) and even mindfulness based therapies, at least 60% of individuals with SUD are likely to relapse within one year post treatment, suggesting a need for innovative approaches to treatment. Craving and Impulsivity are considered hallmarks of addiction, thus targeting these features should be primary concern in developing treatment program. The aim of this paper was to examine the available research on the feasibility of a novel neuromodulation technique, transcranial direct current stimulation (tDCS) and physical exercise in reducing craving and impulsivity in drug dependent patients. My review has shown that physical exercise, in the form of a structured aerobic exercise and non-invasive modulation technique (tDCS) represent a potentially useful, cost free, easy employed intervention strategies for individuals with drug dependence. Neurobiological and molecular mechanisms of action of tDCS and exercise could possibly mediate the beneficial effects on craving and impulsivity.

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“…The present study adds evidence to neuromodulation clinical trials in AUD by: (a) Collecting pre- and post-tDCS resting fMRI data to examine underlying brain connectivity changes, (b) Merging the use of tDCS paired with cognitive training to control participants’ effort and engagement during the stimulation session; (c) Using CDA to determine the causal connectivity from the stimulation site (LDLPFC) to previously defined addiction networks known to support abstinence [ 9 , 10 ], and (d) Tracking relapse outcome over a 4-month follow-up period, longer than follow-up periods in previous clinical trials [ 3 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

et al. 2023

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Transcranial direct current stimulation of the frontal-parietal-temporal brain areas reduces cigarette consumption in abstinent heroin users

Cited by 5 publications

References 33 publications

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

Rehabilitation implications of new tDCS, aerobic exercise, and impulsivity in drug addiction and drug use disorders

Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks

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