Transcranial Direct Current Stimulation of the Leg Motor Cortex Enhances Coordinated Motor Output During Walking With a Large Inter-Individual Variability

Asseldonk, Edwin H.F. van; Boonstra, Tjitske

doi:10.1016/j.brs.2015.10.001

Cited by 40 publications

(38 citation statements)

References 37 publications

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“…There is a large inter-individual variation in the outcome of tDCS over the hand motor cortex (Wiethoff et al, 2014; Laakso et al, 2015, 2016), with approximately one-half of subjects failing to respond to the stimulation in the expected manner (Wiethoff et al, 2014). Recently, such a large inter-individual variation was also observed in tDCS over the leg motor cortex (Madhavan et al, 2016; van Asseldonk and Boonstra, 2016). As the percentage of those who had a clinically meaningful effect was larger in the tDCS group than in the sham group, it is possible that an additive effect of muscle strengthening may exist in some individuals in the tDCS group.…”

Section: Discussionmentioning

confidence: 81%

Transcranial Direct Current Stimulation Does Not Affect Lower Extremity Muscle Strength Training in Healthy Individuals: A Triple-Blind, Sham-Controlled Study

et al. 2017

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The present study investigated the effects of anodal transcranial direct current stimulation (tDCS) on lower extremity muscle strength training in 24 healthy participants. In this triple-blind, sham-controlled study, participants were randomly allocated to the anodal tDCS plus muscle strength training (anodal tDCS) group or sham tDCS plus muscle strength training (sham tDCS) group. Anodal tDCS (2 mA) was applied to the primary motor cortex of the lower extremity during muscle strength training of the knee extensors and flexors. Training was conducted once every 3 days for 3 weeks (7 sessions). Knee extensor and flexor peak torques were evaluated before and after the 3 weeks of training. After the 3-week intervention, peak torques of knee extension and flexion changed from 155.9 to 191.1 Nm and from 81.5 to 93.1 Nm in the anodal tDCS group. Peak torques changed from 164.1 to 194.8 Nm on extension and from 78.0 to 85.6 Nm on flexion in the sham tDCS group. In both groups, peak torques of knee extension and flexion significantly increased after the intervention, with no significant difference between the anodal tDCS and sham tDCS groups. In conclusion, although the administration of eccentric training increased knee extensor and flexor peak torques, anodal tDCS did not enhance the effects of lower extremity muscle strength training in healthy individuals. The present null results have crucial implications for selecting optimal stimulation parameters for clinical trials.

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Section: Discussionmentioning

confidence: 81%

Transcranial Direct Current Stimulation Does Not Affect Lower Extremity Muscle Strength Training in Healthy Individuals: A Triple-Blind, Sham-Controlled Study

et al. 2017

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“…In particular cases, nearly half of all stimulated participants do not respond to stimulation as anticipated [71]. Inter-individual variability in tDCS responsiveness has been observed for hand [69][70][71] and leg area of M1 [72,73]. TMS can be used as a countermeasure to ensure consideration of individualities concerning cortical representations.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Transcranial Direct Current Stimulation Improves Maximum Isometric Force Production during Isometric Barbell Squats

Kenville

Maudrich

et al. 2020

Brain Sciences

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Maximum voluntary contraction force (MVC) is an important predictor of athletic performance as well as physical fitness throughout life. Many everyday life activities involve multi-joint or whole-body movements that are determined in part through optimized muscle strength. Transcranial direct current stimulation (tDCS) has been reported to enhance muscle strength parameters in single-joint movements after its application to motor cortical areas, although tDCS effects on maximum isometric voluntary contraction force (MIVC) in compound movements remain to be investigated. Here, we tested whether anodal tDCS and/or sham stimulation over primary motor cortex (M1) and cerebellum (CB) improves MIVC during isometric barbell squats (iBS). Our results provide novel evidence that CB stimulation enhances MIVC during iBS. Although this indicates that parameters relating to muscle strength can be modulated through anodal tDCS of the cerebellum, our results serve as an initial reference point and need to be extended. Therefore, further studies are necessary to expand knowledge in this area of research through the inclusion of different tDCS paradigms, for example investigating dynamic barbell squats, as well as testing other whole-body movements.

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“…Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation (NIBS) technique capable of influencing spontaneous neuronal activity by increasing or decreasing the average resting membrane potential of neuronal populations underneath, respectively, positively (i.e., anode) and negatively (cathode) charged scalp electrodes (Paulus, 2003) (Nitsche & Paulus, 2001). For instance, when applied to the motor system, tDCS has been found to increase corticomotor excitability—up to 90 min following stimulation (Nitsche & Paulus, 2001)—and to enhance motor performance in healthy individuals—up to 45 min after stimulation's cessation (van Asseldonk & Boonstra, 2016)—possibly acting on cortical plasticity mechanisms (Antal, Terney, Poreisz, & Paulus, 2007; Boros, Poreisz, Münchau, Paulus, & Nitsche, 2008; Fritsch et al., 2010; Furubayashi et al., 2008; Nitsche & Paulus, 2000; Nitsche et al., 2005; Uy, Ridding, Hillier, Thompson, & Miles, 2003). Moreover, results from studies on clinical populations with motor deficits suggest tDCS as a promising neuromodulatory tool to restore motor function (Liew, Santarnecchi, Buch, & Cohen, 2014) (for a review see Sánchez‐Kuhn, Pérez‐Fernández, Cánovas, Flores, & Sánchez‐Santed, 2017).…”

Section: Introductionmentioning

confidence: 99%

Impact of network‐targeted multichannel transcranial direct current stimulation on intrinsic and network‐to‐network functional connectivity

Mencarelli

Menardi

Neri

et al. 2020

J of Neuroscience Research

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Dynamics within and between functional resting‐state networks have a crucial role in determining both healthy and pathological brain functioning in humans. The possibility to noninvasively interact and selectively modulate the activity of networks would open to relevant applications in neuroscience. Here we tested a novel approach for multichannel, network‐targeted transcranial direct current stimulation (net‐tDCS), optimized to increase excitability of the sensorimotor network (SMN) while inducing cathodal inhibitory modulation over prefrontal and parietal brain regions negatively correlated with the SMN. Using an MRI‐compatible multichannel transcranial electrical stimulation (tES) device, 20 healthy participants underwent real and sham tDCS while at rest in the MRI scanner. Changes in functional connectivity (FC) during and after stimulation were evaluated, looking at the intrinsic FC of the SMN and the strength of the negative connectivity between SMN and the rest of the brain. Standard, bifocal tDCS targeting left motor cortex (electrode ~C3) and right frontopolar (~Fp2) regions was tested as a control condition in a separate sample of healthy subjects to investigate network specificity of multichannel stimulation effects. Net‐tDCS induced greater FC increase over the SMN compared to bifocal tDCS, during and after stimulation. Moreover, exploratory analysis of the impact of net‐tDCS on negatively correlated networks showed an increase in the negative connectivity between SMN and prefrontal/parietal areas targeted by cathodal stimulation both during and after real net‐tDCS. Results suggest preliminary evidence of the possibility of manipulating distributed network connectivity patterns through net‐tDCS, with potential relevance for the development of cognitive enhancement and therapeutic tES solutions.

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Transcranial Direct Current Stimulation of the Leg Motor Cortex Enhances Coordinated Motor Output During Walking With a Large Inter-Individual Variability

Abstract: Background

Cited by 40 publications

References 37 publications

Transcranial Direct Current Stimulation Does Not Affect Lower Extremity Muscle Strength Training in Healthy Individuals: A Triple-Blind, Sham-Controlled Study

Transcranial Direct Current Stimulation Does Not Affect Lower Extremity Muscle Strength Training in Healthy Individuals: A Triple-Blind, Sham-Controlled Study

Cerebellar Transcranial Direct Current Stimulation Improves Maximum Isometric Force Production during Isometric Barbell Squats

Impact of network‐targeted multichannel transcranial direct current stimulation on intrinsic and network‐to‐network functional connectivity

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