Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients

Rossi, Costanza; Sallustio, Fabrizio; Legge, Silvia Di; Stanzione, Paolo; Koch, Giacomo

doi:10.1111/j.1468-1331.2012.03703.x

Cited by 130 publications

(98 citation statements)

References 9 publications

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“…One study applied anodal TDCS at 2 mA for 20 min or sham TDCS during five daily sessions to the ipsilesional primary motor cortex (M1) in acute stroke patients starting on the 2nd day from stroke onset and assessed the motor function of patients at stroke onset, 5 days after stroke, and after 3 months. They did not observe any significant difference in motor function between the TDCS and sham groups, indicating that TDCS application from day 2 to day 5 after stroke did not cause motor function improvement (Rossi et al, 2012). In our study, TDCS application from day 1 to day 3 after cerebral infarction did not improve the BWT scores on day 3, but significant improvement of motor function was observed on days 7 and 14 in rats receiving continuous application of TDCS from day 1 to day 7 and from day 1 to day 14.…”

Section: So Group Mcao Group Tdcs Groupmentioning

confidence: 78%

Effects of transcranial direct current stimulation on hemichannel pannexin-1 and neural plasticity in rat model of cerebral infarction

Jiang

Zhang

et al. 2012

Neuroscience

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Section: So Group Mcao Group Tdcs Groupmentioning

confidence: 78%

Effects of transcranial direct current stimulation on hemichannel pannexin-1 and neural plasticity in rat model of cerebral infarction

Jiang

Zhang

et al. 2012

Neuroscience

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“…In contrast, one large study [94] found no improvement in clinical outcome with acute (i.e., 48 hours) tDCS.…”

Section: Summary Of Findings and Future Workmentioning

confidence: 85%

Treatments for Neurological Gait and Balance Disturbance: The Use of Noninvasive Electrical Brain Stimulation

Kaski

Bronstein

2014

Advances in Neuroscience

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Neurological gait disorders are a common cause of falls, morbidity, and mortality, particularly amongst the elderly. Neurological gait and balance impairment has, however, proved notoriously difficult to treat. The following review discusses some of the first experiments to modulate gait and balance in healthy adults using anodal transcranial direct current stimulation (tDCS) by stimulating both cerebral hemispheres simultaneously. We review and discuss published data using this novel tDCS approach, in combination with physical therapy, to treat locomotor and balance disorders in patients with small vessel disease (leukoaraiosis) and Parkinson’s disease. Finally, we review the use of bihemispheric anodal tDCS to treat gait impairment in patients with stroke in the subacute phase. The findings of these studies suggest that noninvasive electrical stimulation techniques may be a useful adjunct to physical therapy in patients with neurological gait disorders, but further mutlicentre randomized sham-controlled studies are needed to evaluate whether experimental tDCS use can translate into mainstream clinical practice for the treatment of neurological gait disorders.

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“…In stroke patients with good recovery, there is often a transient bilateral activation that occurs in both cortical hemispheres while moving the affected limb, suggesting the involvement of contralesional cortical activation in stroke recovery [23][24][25]. Data from our laboratory and that of others have shown that increasing the excitability of the ipsilesional motor cortex (iM1) after stroke is beneficial for recovery [5,23,26,27]. However, it is less clear whether activation of other areas such as the contralesional cortex is beneficial or maladaptive, or not involved [28].…”

Section: Functional Recovery After Strokementioning

confidence: 95%

Optogenetic Approaches to Target Specific Neural Circuits in Post-stroke Recovery

2016

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Stroke is a leading cause of death and disability in the USA, yet treatment options are very limited. Functional recovery can occur after stroke and is attributed, in part, to rewiring of neural connections in areas adjacent to or remotely connected to the infarct. A better understanding of neural circuit rewiring is thus an important step toward developing future therapeutic strategies for stroke recovery. Because stroke disrupts functional connections in peri-infarct and remotely connected regions, it is important to investigate brain-wide network dynamics during post-stroke recovery. Optogenetics is a revolutionary neuroscience tool that uses bioengineered lightsensitive proteins to selectively activate or inhibit specific cell types and neural circuits within milliseconds, allowing greater specificity and temporal precision for dissecting neural circuit mechanisms in diseases. In this review, we discuss the current view of post-stroke remapping and recovery, including recent studies that use optogenetics to investigate neural circuit remapping after stroke, as well as optogenetic stimulation to enhance stroke recovery. Multimodal approaches employing optogenetics in conjunction with other readouts (e.g., in vivo neuroimaging techniques, behavior assays, and next-generation sequencing) will advance our understanding of neural circuit reorganization during post-stroke recovery, as well as provide important insights into which brain circuits to target when designing brain stimulation strategies for future clinical studies.

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Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients

Abstract: Five-daily sessions of anodal TDCS to the ipsilesional M1 appear to be safe in acute stroke patients but do not improve clinical outcome.

Cited by 130 publications

References 9 publications

Effects of transcranial direct current stimulation on hemichannel pannexin-1 and neural plasticity in rat model of cerebral infarction

Effects of transcranial direct current stimulation on hemichannel pannexin-1 and neural plasticity in rat model of cerebral infarction

Treatments for Neurological Gait and Balance Disturbance: The Use of Noninvasive Electrical Brain Stimulation

Optogenetic Approaches to Target Specific Neural Circuits in Post-stroke Recovery

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