Transcranial direct current stimulation-mediated miR-298-5p downregulation enhances autophagy by targeting LC3 to promote motor recovery after spinal cord injury
Qinhe Pan,
Jianmin Chen,
Weifeng Zuo
et al.
Abstract:While transcranial direct current stimulation (tDCS) has been shown to contribute to motor recovery after spinal cord injury (SCI), the underlying mechanisms behind this process remain unclear. In the present study, we sought to explore whether tDCS can inhibit apoptosis, activate autophagy, and promote functional recovery. To achieve this aim, SCI was induced in rats using a modified Allen’s method and managed with tDCS. MicroRNAs responding to tDCS administration were detected using microRNA sequencing and v… Show more
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