Transcranial Direct Current Stimulation in Epilepsy

San-Juan, Daniel; Morales-Quezada, León; Garduño, Adolfo Josué Orozco; Alonso-Vanegas, Mario; González-Aragón, Maricarmen Fernández; Lopez, Dulce; Gregorio, Rafael Vázquez; Anschel, David J.; Fregni, Felipe

doi:10.1016/j.brs.2015.01.001

Cited by 110 publications

(76 citation statements)

References 56 publications

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“…Because cathodal tDCS has the potential to reduce cortical excitability, it could be a useful tool to diminish cortical hyperexcitability in children with refractory focal epilepsy. Studies in animal models indeed have reported that direct current stimulation has anticonvulsant effects (Liebetanz et al, 2006) and suppresses epileptiform activity (San-Juan et al, 2015). In accordance, pilot studies in adults have shown significant reductions of seizures by tDCS (Fregni et al, 2006;San-Juan et al, 2015).…”

Section: Epilepsymentioning

confidence: 69%

“…Studies in animal models indeed have reported that direct current stimulation has anticonvulsant effects (Liebetanz et al, 2006) and suppresses epileptiform activity (San-Juan et al, 2015). In accordance, pilot studies in adults have shown significant reductions of seizures by tDCS (Fregni et al, 2006;San-Juan et al, 2015). In children, this rationale has been explored in a sham-controlled study using a single session of cathodal tDCS at 1 mA for 20 min (the cathode positioned over the seizure focus and the anode over the contralateral shoulder).…”

Section: Epilepsymentioning

confidence: 96%

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Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2017

Reviews in the Neurosciences

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AbstractTranscranial direct current stimulation (tDCS) is a neuromodulatory noninvasive brain stimulation tool with potential to increase or reduce regional and remote cortical excitability. Numerous studies have shown the ability of this technique to induce neuroplasticity and to modulate cognition and behavior in adults. Clinical studies have also demonstrated the ability of tDCS to induce therapeutic effects in several central nervous system disorders. However, knowledge about its ability to modulate brain functions in children or induce clinical improvements in pediatrics is limited. The objective of this review is to describe relevant data of some recent studies that may help to understand the potential of this technique in children with specific regard to effective and safe treatment of different developmental disorders in pediatrics. Overall, the results show that standard protocols of tDCS are well tolerated by children and have promising clinical effects. Nevertheless, treatment effects seem to be partially heterogeneous, and a case of a seizure in a child with previous history of infantile spasms and diagnosed epilepsy treated with tDCS for spasticity was reported. Further research is needed to determine safety criteria for tDCS use in children and to elucidate the particular neurophysiological changes induced by this neuromodulatory technique when it is applied in the developing brain.

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Section: Epilepsymentioning

confidence: 69%

Section: Epilepsymentioning

confidence: 96%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2017

Reviews in the Neurosciences

View full text Add to dashboard Cite

show abstract

“…"Ref obtained" describes all references obtained, the following columns describes the number of references that were excluded after reading title/abstract, that were full-text assessed and that were excluded after this step. In a few cases, additional references were obtained from other sources, such as the references lists of recent articles and reviews (e.g., (2,4,(39)(40)(41)(42)(43)(44)(45)(46)). Main causes of exclusion after reading title/abstract were: (a) other study designs (case reports, series of cases, non-controlled trials, absence of a sham group); (b) other methods of brain stimulations; (c) studies in animals; (d) other types of publications, such as systematic reviews, meta-analysis and editorial; (e) duplicated data; (f) studies in children and adolescents; (g) other reasons.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review on the Acceptability and Tolerability of Transcranial Direct Current Stimulation Treatment in Neuropsychiatry Trials

et al. 2016

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“…In healthy adults, tDCS offers a tool for testing causal relationships between brain regions and their underlying cognitive functions (e.g., motor control, working memory, language) [5-8]. This technique has also been tested in clinical populations for a wide variety of uses, ranging from psychiatric conditions to neurological disorders caused by stroke and neurodegenerative diseases [9-15]. Based on research in animals and humans, it is generally thought that applying anodal tDCS to a brain area leads to increased neural excitability in that region, while cathodal stimulation leads to decreased neural excitability [1, 2, 16-21].…”

Section: Introductionmentioning

confidence: 99%

A Meta-analysis of Transcranial Direct Current Stimulation Studies Examining the Reliability of Effects on Language Measures

et al. 2015

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Background Transcranial direct current stimulation (tDCS) is a brain stimulation technique used to examine causal relationships between brain regions and cognitive functions. The effects from tDCS are complex, and the extent to which stimulation reliably affects different cognitive domains is not fully understood and continues to be debated. Objective/Hypothesis To conduct a meta-analysis of studies examining the effects of single-session anodal tDCS on language. Methods The meta-analysis examined the behavioral results from eleven experiments of single-session anodal tDCS and language processing in healthy adults. The means and standard deviations of the outcome measures were extracted from each experiment and entered into the meta-analyses. In the first analysis, we examined the effects of single-session tDCS across all language studies. Next, a series of sub-analyses examined the effects of tDCS on specific tasks and stimulation protocols. Results There was a significant effect from anodal single-session tDCS in healthy adults compared to sham (p=0.001) across all language measures. Next, we found significant effects on specific stimulation protocols (e.g., offline measures, p=0.002), as well as specific tasks and electrode montages (e.g., verbal fluency measures and left prefrontal cortex, p=0.035). Conclusions The results indicate that single-session tDCS produces significant and reliable effects on language measures in healthy adults.

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Transcranial Direct Current Stimulation in Epilepsy

Cited by 110 publications

References 56 publications

Applications of transcranial direct current stimulation in children and pediatrics

Applications of transcranial direct current stimulation in children and pediatrics

A Systematic Review on the Acceptability and Tolerability of Transcranial Direct Current Stimulation Treatment in Neuropsychiatry Trials

A Meta-analysis of Transcranial Direct Current Stimulation Studies Examining the Reliability of Effects on Language Measures

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