Transcranial Direct Current Stimulation Improves Semantic Speech–Gesture Matching in Patients With Schizophrenia Spectrum Disorder

Schülke, Rasmus; Straube, Benjamin

doi:10.1093/schbul/sby144

Cited by 28 publications

(32 citation statements)

References 53 publications

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“…Conclusions from this study are however limited by the low number of participants and their divergent disease stage (3 out 6 were chronic rather than acute/ subacute stroke patients). In line with our study, just recently, facilitatory effects of cathodal tDCS on gesture processing were found in schizophrenia, further underlining the validity of using non-invasive brain stimulation methods to improve gesture performance [47].…”

Section: Discussionsupporting

confidence: 91%

Interhemispheric facilitation of gesturing: A combined theta burst stimulation and diffusion tensor imaging study

et al. 2020

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Background: Imaging studies point to a posture (finger vs. hand) and domain-specific neural basis of gestures. Furthermore, modulation of gestures by theta burst stimulation (TBS) may depend on interhemispheric disinhibition. Objective/Hypothesis: In this randomized sham-controlled study, we hypothesized that dual site continuous TBS over left inferior frontal gyrus (IFG-L) and right inferior parietal gyrus (IPL-R) predominantly affects pantomime of finger postures. Furthermore, we predicted that dual cTBS improves imitation of hand gestures if the effect correlates with measures of callosal connectivity. Methods: Forty-six healthy subjects participated in this study and were targeted with one train of TBS in different experimental sessions: baseline, sham, single site IFG-L, dual IFG-L/IPL-R, single site IPL-R. Gestures were evaluated by blinded raters using the Test for Upper Limb Apraxia (TULIA) and Postural Imitation Test (PIT). Callosal connectivity was analyzed by diffusion tensor imaging (DTI). Results: Dual cTBS significantly improved TULIA total (F [3, 28] ¼ 4.118, p ¼ .009), but did not affect TULIA pantomime. The beneficial effect was driven by the cTBS over IPL-R, which improved TULIA imitation (p ¼ .038). Furthermore, TULIA imitation significantly correlated with the microstructure (fractional anisotropy) of the splenium (r ¼ 0.420, p ¼ .026), corrected for age and whole brain volume. Conclusions: The study suggests that inhibition of IPL-R largely accounted for improved gesturing, possibly through transcallosal facilitation of IPL-L. Therefore, the findings may be relevant for the treatment of apraxic stroke patients. Gesture pantomime and postural gestures escaped the modulation by dual cTBS, suggesting a more widespread and/or variable neural representation.

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Section: Discussionsupporting

confidence: 91%

Interhemispheric facilitation of gesturing: A combined theta burst stimulation and diffusion tensor imaging study

et al. 2020

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“…Nonverbal trainings are rare in the field of psychiatry. One study executed no training, but could show positive effects of transcranial direct current stimulation (tDCS) on gesture integration in a group of patients with schizophrenia spectrum disorder (68). Another study could show a benefit from single session transcranial magnetic stimulation (TMS) also for gesture production in patients with schizophrenia (69).…”

Section: Current Treatments For Patients With Schizophreniamentioning

confidence: 99%

“…been successfully applied in a large number of fMRI (14-16, 84), EEG (85), tDCS (68,86) and patient studies including patients with schizophrenia (30,31). Altogether, we use six categories of videos in our study: videos containing.…”

Section: Stimulimentioning

confidence: 99%

“…In the first perceptual task, the videos are presented through a laptop screen. Participants are supposed to rate the matching of gesture and speech content [see (68,86)]. Considering the connection between speech/gesture perception and working memory (14,21,61), the second perceptual task is a speechgesture-n-back task (one back, two back and three back with speech, gesture and speech + gesture videos).…”

Section: Msg Training Proceduresmentioning

confidence: 99%

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A Multimodal Speech-Gesture Training Intervention for Patients With Schizophrenia and Its Neural Underpinnings – the Study Protocol of a Randomized Controlled Pilot Trial

Riedl¹,

Nagels²,

Sammer³

et al. 2020

Front. Psychiatry

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Dysfunctional social communication is one of the most stable characteristics in patients with schizophrenia that also affects quality of life. Interpreting abstract speech and integrating nonverbal modalities is particularly affected. Considering the impact of communication on social life but failure to treat communication dysfunctions with usual treatment, we will investigate the possibility to improve verbal and non-verbal communication in schizophrenia by applying a multimodal speech-gesture training (MSG training). Here we describe the newly developed MSG training program and the study design for the first clinical investigation. The intervention contains perceptive rating (match/mismatch of sentence and gesture) and memory tasks (n-back tasks), imitation and productive tasks (e.g., SG fluency-similar to verbal fluency where words are accompanied by gesture). In addition, we offer information about gesture as metalearning element as well as homework for reasons of transfer to everyday life as part of every session. In the MSG training intervention, we offer eight sessions (60 min each) of training. The first pilot study is currently conducted as a single-center, randomized controlled trial of speech-gesture intervention versus wait-list control with a follow-up. Outcomes are measured through pre-post-fMRI and standardized psychological questionnaires comparing two subject groups (30 patients with schizophrenia and 30 healthy controls). Patients and healthy controls are randomized in two intervention groups (with 20 being in the wait-training group and 10 in the training-follow-up group). With our study design we will be able to demonstrate the beneficial effect of the MSG training intervention on behavioral and neural levels.Clinical Trial Registration: DRKS.de, identifier DRKS00015118.

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“…A more recent study found that for healthy individuals, anodal tDCS (atDCS) over the motor cortex improved semantic word retrieval performance (Martin et al, 2017). In terms of gesture comprehension, studies have used tDCS over the IFG to investigate the role of this region in processing gestural-verbal stimuli (Cohen-Maximov et al, 2015; Schulke and Straube, 2017, 2018). Gesture prime clips were implemented for word targets.…”

Section: Introductionmentioning

confidence: 99%

Role of Sensorimotor Cortex in Gestural-Verbal Integration

Hayek

Flöel

Antonenko

2018

Front. Hum. Neurosci.

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Action comprehension that is related to language or gestural integration has been shown to engage the motor system in the brain, thus providing preliminary evidence for the gestural-verbal embodiment concept. Based on the involvement of the sensorimotor cortex (M1) in language processing, we aimed to further explore its role in the cognitive embodiment necessary for gestural-verbal integration. As such, we applied anodal (excitatory) and sham transcranial direct current stimulation (tDCS) over the left M1 (with reference electrode over the contralateral supraorbital region) during a gestural-verbal integration task where subjects had to make a decision about the semantic congruency of the gesture (prime) and the word (target). We used a cross-over within-subject design in young subjects. Attentional load and simple reaction time (RT) tasks served as control conditions, applied during stimulation (order of three tasks was counterbalanced). Our results showed that anodal (atDCS) compared to sham tDCS (stDCS) reduced RTs in the gestural-verbal integration task, specifically for incongruent pairs of gestures and verbal expressions, with no effect on control task performance. Our findings provide evidence for the involvement of the sensorimotor system in gestural-verbal integration performance. Further, our results suggest that functional modulation induced by sensorimotor tDCS may be specific to gestural-verbal integration. Future studies should now evaluate the modulatory effect of tDCS on semantic congruency by using tDCS over additional brain regions and include assessments of neural connectivity.

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Transcranial Direct Current Stimulation Improves Semantic Speech–Gesture Matching in Patients With Schizophrenia Spectrum Disorder

Cited by 28 publications

References 53 publications

Interhemispheric facilitation of gesturing: A combined theta burst stimulation and diffusion tensor imaging study

Interhemispheric facilitation of gesturing: A combined theta burst stimulation and diffusion tensor imaging study

A Multimodal Speech-Gesture Training Intervention for Patients With Schizophrenia and Its Neural Underpinnings – the Study Protocol of a Randomized Controlled Pilot Trial

Role of Sensorimotor Cortex in Gestural-Verbal Integration

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