Transcranial Direct Current Stimulation for Pain Disorders: Challenges and New Frontiers

Fitzgibbon, Bernadette M.; Schabrun, Siobhan M

doi:10.1002/cpt.1544

Cited by 2 publications

(2 citation statements)

References 7 publications

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Section: Brain Stimulation Methods Used In Neurologic and Psychiatricmentioning

confidence: 99%

“…Transcranial direct current stimulation is very well tolerated, and has been used as a treatment for both neurological (e.g., pain) and psychiatric disorders (e.g., depression and schizophrenia). Fitzgibbon et al 21 and Rajji et al 22 provide evidence for the current and potential future use of these devices in relation to treatment for pain disorders and for prevention of, and treatment for, Alzheimer's disease. What is most appealing about tDCS as a treatment option is its safety, portability, ease of use, and the potential to enhance cognition in vulnerable populations to which few if any treatments are available.…”

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confidence: 99%

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A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation

Daskalakis

Tyndale

2019

Clin Pharma and Therapeutics

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Section: Brain Stimulation Methods Used In Neurologic and Psychiatricmentioning

confidence: 99%

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confidence: 99%

A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation

Daskalakis

Tyndale

2019

Clin Pharma and Therapeutics

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Supplementing transcranial direct current stimulation to local infiltration series for refractory neuropathic craniocephalic pain: A randomized controlled pilot trial

et al. 2023

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BackgroundSome patients with neuralgia of cranial nerves with otherwise therapy-refractory pain respond to invasive therapy with local anesthetics. Unfortunately, pain regularly relapses despite multimodal pain management. Transcranial direct current stimulation (tDCS) may prolong pain response due to neuro-modulatory effects.MethodsThis controlled clinical pilot trial randomized patients to receive anodal, cathodal or sham-tDCS stimulation prior to local anesthetic infiltration. Pain attenuation, quality-of-life and side effects were assessed and compared with historic controls to estimate effects of tDCS stimulation setting.ResultsAltogether, 17 patients were randomized into three groups with different stimulation protocols. Relative reduction of pain intensity in per protocol treated patients were median 73%, 50% and 69% in anodal, cathodal and sham group, respectively (p = 0.726). Compared with a historic control group, a lower rate of responders with 50% reduction of pain intensity indicates probable placebo effects (OR 3.41 stimulation vs. non-stimulation setting, NNT 3.63). 76.9% (n = 10) of tDCS patients reported mild side-effects. Of all initially included 17 patients, 23.5% (n = 4) withdrew their study participation with highest proportion in the cathodal group (n = 3). A sample size calculation for a confirmatory trial revealed 120 patients using conservative estimations.DiscussionThis pilot trial does not support series of anodal tDCS as neuro-modulatory treatment to enhance pain alleviation of local anesthetic infiltration series. Notably, results may indicate placebo effects of tDCS settings. Feasibility of studies in this population was limited due to relevant drop-out rates. Anodal tDCS warrants further confirmation as neuro-modulatory pain treatment option.

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Transcranial Direct Current Stimulation for Pain Disorders: Challenges and New Frontiers

Cited by 2 publications

References 7 publications

A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation

A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation

Supplementing transcranial direct current stimulation to local infiltration series for refractory neuropathic craniocephalic pain: A randomized controlled pilot trial

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