Transcranial direct current stimulation based on quantitative electroencephalogram combining positive psychotherapy for major depression

Khayyer, Zahra; Ngaosuvan, Leonard; Sikström, Sverker; Ghaderi, Amir

doi:10.3233/jin-170045

Cited by 15 publications

(10 citation statements)

References 38 publications

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“…In another recent clinical trial, researchers compared tDCS, positive psychotherapy, and combined strategy for the treatment of depression. 15 Nine women (mean age of 45 years) with resistant major depression were assigned randomly to 3 groups of equal size. For tDCS, 12 sessions of treatment with anodal stimulation of 1.5 mA for 15 minutes was administered over F4 or F3 areas.…”

Section: Discussionmentioning

confidence: 99%

“…However, while there are some studies with sufficient power, 13 there are other researches with poor methodological quality, lack of uniformity, and small sample sizes that decrease the generalizability of the conclusions. 14,15 We need less expensive and more beneficial methods for the treatment of patients with refractory major depression. Until reliable information about different therapeutic methods is collected, it is difficult to design the best intervention strategy for treatment-resistant depression.…”

Section: Introductionmentioning

confidence: 99%

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Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

et al. 2019

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In the current study, we tried to evaluate the effect of transcranial direct current stimulation (tDCS) on treatment-resistant major depression. We carried out a double-blind randomized sham-controlled trial was conducted in University Hospitals. Individuals with less than 50% decrease in the intensity of depression after 8 weeks of treatment with selective serotonin reuptake inhibitors were recruited. Thirty patients (16 women) with a mean (SD) age of 47.2 (12.0) years were randomly allocated to 2 groups. For the active group we administered 2-mA stimulation 20 minutes for each session, with 30 seconds ramp-up from 0 and 30 seconds ramp-down. For the sham group we administered 30 seconds ramp-up to 2 mA, 10 seconds stimulation, 30 seconds ramp-down, and 20 minutes no current. The anode was fixed on the center of F3, and the cathode on F4, over the dorsolateral prefrontal cortex. We assessed the Hamilton Depression Rating Scale at the baseline (mean difference = 1.0, P = .630), at the last session of tDCS, and at 1-month postintervention. There were statistically significant differences in the mean Hamilton scores after the intervention, and 1 month later in favor of active group; P < .001, and P = .003, respectively. Mixed analysis of variance showed a significant difference in the mean scores for active group P = .010 and pattern of change during the study P < .001 in favor of active intervention. We concluded that tDCS is an efficient therapy for patients with resistant major depression, and the benefits would remain at least for 1 month.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

et al. 2019

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“…Long-term tDCS with 15 treatment periods has been found to affect mood and cognition in 50 and 60%, respectively, of individuals with depression (Al-Kaysi et al, 2017). Similarly, a lower-intensity (1 and 1.5 mA) tDCS protocol also resulted in reduced ERP (Shahsavar et al, 2018) and power spectra (e.g., delta, theta, and alpha frequency bands) (Palm et al, 2009;Khayyer et al, 2018) following stimulation. In particular, combined treatment with positive psychotherapy and tDCS can significantly affect depression.…”

Section: Depressive Disordermentioning

confidence: 98%

“…In particular, combined treatment with positive psychotherapy and tDCS can significantly affect depression. Effects are more pronounced following 3 months of follow-up than with the use of tDCS alone ( Khayyer et al, 2018 ).…”

Section: Depressive Disordermentioning

confidence: 99%

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

2021

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BackgroundBrain disorders are gradually becoming the leading cause of death worldwide. However, the lack of knowledge of brain disease’s underlying mechanisms and ineffective neuropharmacological therapy have led to further exploration of optimal treatments and brain monitoring techniques.ObjectiveThis study aims to review the current state of brain disorders, which utilize transcranial electrical stimulation (tES) and daily usable noninvasive neuroimaging techniques. Furthermore, the second goal of this study is to highlight available gaps and provide a comprehensive guideline for further investigation.MethodA systematic search was conducted of the PubMed and Web of Science databases from January 2000 to October 2020 using relevant keywords. Electroencephalography (EEG) and functional near-infrared spectroscopy were selected as noninvasive neuroimaging modalities. Nine brain disorders were investigated in this study, including Alzheimer’s disease, depression, autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, Parkinson’s disease, stroke, schizophrenia, and traumatic brain injury.ResultsSixty-seven studies (1,385 participants) were included for quantitative analysis. Most of the articles (82.6%) employed transcranial direct current stimulation as an intervention method with modulation parameters of 1 mA intensity (47.2%) for 16–20 min (69.0%) duration of stimulation in a single session (36.8%). The frontal cortex (46.4%) and the cerebral cortex (47.8%) were used as a neuroimaging modality, with the power spectrum (45.7%) commonly extracted as a quantitative EEG feature.ConclusionAn appropriate stimulation protocol applying tES as a therapy could be an effective treatment for cognitive and neurological brain disorders. However, the optimal tES criteria have not been defined; they vary across persons and disease types. Therefore, future work needs to investigate a closed-loop tES with monitoring by neuroimaging techniques to achieve personalized therapy for brain disorders.

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“…Additionally, most clients suffering from depression have low levels of self-compassion (Krieger, Altenstein, Baettig, Doerig, & Holtforth, 2013). Scholars have found that psychological interventions decrease symptoms of depression and improve clients' selfesteem (Khayyer, Ngaosuvan, Sikström, & Ghaderi, 2018). Hence, clients, such as depressed parents of ADHD children, may benefit from interventions aimed at aspects of self-compassion (Wong & Mak, 2013).…”

mentioning

confidence: 99%

Effect of compassion‐focused group therapy on psychological symptoms in mothers of attention‐deficit hyperactivity disorder children: A pilot study

Navab

Dehghani

Salehi

2019

Couns and Psychother Res

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Background Evidence suggests that attention‐deficit/hyperactivity disorder (ADHD) may accentuate varying psychological symptoms in parents. Since mothers are the most likely individuals interacting with ADHD children, it is highly probable that they will be influenced the most. Objectives This pilot study aimed to determine the effect of compassion‐focused group therapy on psychological symptoms of mothers of ADHD children. Methods A pre‐test–post‐test control‐grouped, quasi‐experimental study was carried out on a sample of 20 mothers of children with ADHD who were referred to the Health Centers of Isfahan City in Spring 2017. Prior to the intervention, the mothers’ psychological symptoms were recorded in both groups using the DASS‐21 questionnaire. Then, the mothers (n = 10) in the treatment group underwent 8 weekly sessions of 90‐min, compassion‐focused therapy. Both groups were post‐tested 1 week after the intervention. Finally, the collected data were analysed in SPSS‐23. Results The results of the study showed that, after the intervention, the mothers’ psychological symptoms in the treatment group significantly decreased (pre‐test: 36.10 ± 7.96 vs. post‐test: 33.40 ± 4.28, p value < 0.05), while no significant change was observed in the control group. Depression and anxiety levels showed a significant decrease in the treatment group as compared to the control group (p value < 0.05), while participants’ stress levels remained the same in both groups (p value > 0.05). Conclusion The findings revealed that compassion‐focused therapy resulted in an increase in self‐compassion and inner calmness levels, and a decrease in the use of avoidance coping strategy on the one hand, and the need to regulate emotions and ruminations on the other hand, among the mothers of ADHD children, which subsequently led to a decrease in psychological symptoms.

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Transcranial direct current stimulation based on quantitative electroencephalogram combining positive psychotherapy for major depression

Cited by 15 publications

References 38 publications

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

Effect of compassion‐focused group therapy on psychological symptoms in mothers of attention‐deficit hyperactivity disorder children: A pilot study

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