Transcranial Direct Current Stimulation and Migraine—The Beginning of a Long Journey

Ayache, Samar S.; Chalah, Moussa A.

doi:10.3390/jcm9041194

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…In recent years, noninvasive neuromodulation such as transcranial magnetic stimulation and transcranial direct current stimulation have become important nonpharmacological approach for migraine prevention. 5,35,59 Although the best target for migraine neuromodulation remains to be determined, these techniques mostly focused on the primary motor or visual cortices or the dorsolateral prefrontal cortex. Based on the present findings, we suggest the ACC may be a promising cortical region for migraine neuromodulation.…”

Section: Anterior Cingulate Cortex As the Main Cortical Area Within T...mentioning

confidence: 99%

Migraine chronification is associated with beta-band connectivity within the pain-related cortical regions: a magnetoencephalographic study

Hsiao¹,

Chen

Liu

et al. 2021

PAIN

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Pain disorders are associated with aberrant oscillations in the pain-related cortical regions; however, few studies have investigated the relationship between the functional cortical network and migraine chronification through direct neural signals. Magnetoencephalography was used to record the resting-state brain activity of healthy controls as well as patients with episodic migraine (EM) and chronic migraine (CM). The source-based oscillatory dynamics of the pain-related cortical regions, which comprises 10 node regions (the bilateral primary [SI] and secondary somatosensory cortices, insula, medial frontal cortex, and anterior cingulate cortex [ACC]), were calculated to determine the intrinsic connectivity and node strength at 1 to 40 Hz. The total node strength within the pain-related cortical regions was smaller in the beta band in patients with migraine (70 EM and 80 CM) than in controls (n = 65). In the beta band, the node strength and functional connectivity values of patients with CM and patients with EM differed from those of controls in specific cortical areas, notably the left SI (EM < control) and bilateral ACC (CM < control); moreover, the node strength was lower in patients with CM than in those with EM. In all patients with migraine, negative correlations were observed between headache frequency and node strength in the bilateral ACC. In conclusion, migraine is characterized by reduced beta oscillatory connectivity within the pain-related cortical regions. Reduced beta connectivity in the ACC is linked to migraine chronification. Longitudinal studies should verify whether this oscillation change is a brain signature and a potential neuromodulation target for migraine.

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Section: Anterior Cingulate Cortex As the Main Cortical Area Within T...mentioning

confidence: 99%

Migraine chronification is associated with beta-band connectivity within the pain-related cortical regions: a magnetoencephalographic study

Hsiao¹,

Chen

Liu

et al. 2021

PAIN

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“…Therefore, there is a rationale to propose a-tDCS of the left motor cortex as a therapeutic approach in migraine. Some encouraging results have been published [12,16,[34][35][36]. However, the current level of evidence of the therapeutic effect of tDCS protocols in migraine remains low [19].…”

Section: Introductionmentioning

confidence: 99%

Long-term prophylactic efficacy of transcranial direct current stimulation in chronic migraine. A randomised, patient-assessor blinded, sham-controlled trial

et al. 2022

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Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort

Reece,

Neate,

Davenport

et al. 2023

Acta Neurol Belg

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Background Relationships between stressful life events (SLEs) and health outcomes in people living with multiple sclerosis (plwMS), beyond relapse, are not well-established. We examined associations between SLEs and fatigue and symptoms of depression in plwMS. Methods 948 participants were queried whether they had experienced any of the 16 SLEs (Holmes–Rahe Social Readjustment Rating Scale) in the preceding 12 months. SLEs were summated to estimate SLE number and SLE load (weighted for the degree of associated stress). Cross-sectional associations between SLE (number, load and individual) and fatigue, and depressive symptoms were examined using log-binomial or log-multinomial regression adjusted for age, sex, relapse symptoms, education, MS type at baseline, disability, fatigue, comorbidity, depression, and antidepressant/antifatigue medications, as appropriate. Sub-analyses restricted to SLEs with a negative emotional impact were performed. Results Median SLE number and load were 2 (IQR 1–2) and 57 (IQR 28–97), respectively. SLE number and load were not associated with a higher prevalence of fatigue, or depressive symptoms, even when restricting analyses to SLEs with a perceived negative emotional impact. A new relationship or family member with a negative impact was associated with a threefold and 2.5-fold higher prevalence of depressive symptoms, respectively. Serious illness was associated with a 28% higher prevalence of depressive symptoms. Conclusion Psychological support for SLEs, and/or intervention targeted to SLE appraisal, may be beneficial in mitigating the adverse effects of SLEs with a perceived negative emotional impact on depressive symptoms in plwMS. Potential associations between serious illness and increased prevalence of depressive symptoms may warrant further investigation.

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Transcranial Direct Current Stimulation and Migraine—The Beginning of a Long Journey

Abstract: Migraine, a benign yet disturbing condition, is one of the frequent neurological disorders, affecting up to 15–20% of the worldwide population [...]

Cited by 7 publications

References 32 publications

Migraine chronification is associated with beta-band connectivity within the pain-related cortical regions: a magnetoencephalographic study

Migraine chronification is associated with beta-band connectivity within the pain-related cortical regions: a magnetoencephalographic study

Long-term prophylactic efficacy of transcranial direct current stimulation in chronic migraine. A randomised, patient-assessor blinded, sham-controlled trial

Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort

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