Abstract:In pre-eclamptic patients, we found increased MCA mean velocity before the onset of visual disturbance. Transcranial Doppler may be useful for the evaluation of cerebral hemodynamics and the prediction of eclampsia.
“…The mechanism of action of magnesium sulphate is uncertain, but there is evidence from computed tomography and magnetic resonance angiographic studies implicating cerebral vasospasm and ischemia in the genesis of eclampsia (12–14). Magnesium seems to reverse and ameliorate the effects of cerebral ischemia (15).…”
Half of the standard dose of magnesium sulphate appeared to be sufficient to control convulsions effectively and serum levels of magnesium remained lower than levels which produce toxicity.
“…The mechanism of action of magnesium sulphate is uncertain, but there is evidence from computed tomography and magnetic resonance angiographic studies implicating cerebral vasospasm and ischemia in the genesis of eclampsia (12–14). Magnesium seems to reverse and ameliorate the effects of cerebral ischemia (15).…”
Half of the standard dose of magnesium sulphate appeared to be sufficient to control convulsions effectively and serum levels of magnesium remained lower than levels which produce toxicity.
“…The mechanism of action of magnesium sulphate is uncertain, but there is evidence from computed tomography and magnetic resonance angiographic studies implicating cerebral vasospasm and ischemia in the genesis of eclampsia (12)(13)(14). Magnesium seems to reverse and ameliorate the effects of cerebral ischemia (15).…”
Half of the standard dose of magnesium sulphate appeared to be sufficient to control convulsions effectively and serum levels of magnesium remained lower than levels which produce toxicity.
“…The fact that raised V mean values were found symmetrically in both hemispheres, in all basal arteries, over the whole insonated length of the arteries and also in the ICA in the three eclamptic patients suggests vasodilatation as the underlying mechanism. Ohno and coworkers 86 found an increase in V mean ICA of 11% in 18 pre-eclamptic women, accompanied by an increase in V mean MCA of 67%. This finding is in keeping with our results, i.e.…”
Section: Interpretation Of Tcd Findings In Patients With Pre-eclampsimentioning
Considerable differences in cerebral hemodynamics were observed in the various types of pregnancy-related hypertensive disorders examined in this study. Our findings in patients with pre-eclampsia/eclampsia syndrome suggest a breakdown of autoregulation with hyperperfusion and vasogenic edema being the most probable pathophysiological mechanism.
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