Transcranial Alternating Current Stimulation: A Potential Modulator for Pathological Oscillations in Parkinson’s Disease?

Teo, Wei‐Peng; Hendy, Ashlee M.; Goodwill, Alicia M.; Loftus, Andrea M.

doi:10.3389/fneur.2017.00185

Cited by 8 publications

(7 citation statements)

References 41 publications

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“…Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potential treatment for cognitive impairment in Parkinson's disease (PD), with effects that appear to be additive to dopaminergic medicines ( 73 ). While it is difficult to pinpoint the exact role of pathological neural oscillations in certain aspects of motor and cognitive function, current research clearly suggests that these pathological oscillations interact and contribute to the motor and cognitive deficits seen in Parkinson's disease ( 74 ). Another study found that repetitive transcranial magnetic stimulation (rTMS) over (motor region) M1 is beneficial for motor function and may have a slight favorable effect on cognition ( 73 ).…”

Section: Tms In Movement Disordersmentioning

confidence: 99%

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

2022

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Transcranial Magnetic Stimulation (TMS) has widespread use in research and clinical application. For psychiatric applications, such as depression or OCD, repetitive TMS protocols (rTMS) are an established and globally applied treatment option. While promising, rTMS is not yet as common in treating neurological diseases, except for neurorehabilitation after (motor) stroke and neuropathic pain treatment. This may soon change. New clinical studies testing the potential of rTMS in various other neurological conditions appear at a rapid pace. This can prove challenging for both practitioners and clinical researchers. Although most of these neurological applications have not yet received the same level of scientific/empirical scrutiny as motor stroke and neuropathic pain, the results are encouraging, opening new doors for TMS in neurology. We here review the latest clinical evidence for rTMS in pioneering neurological applications including movement disorders, Alzheimer's disease/mild cognitive impairment, epilepsy, multiple sclerosis, and disorders of consciousness.

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Section: Tms In Movement Disordersmentioning

confidence: 99%

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

2022

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“…Cross-frequency phaseamplitude coupling between amplitude of slow high frequency oscillation (200-300 Hz) and phase of low-beta (13-22 Hz) has been noted in the OFF phase of PD (López-Azcárate et al, 2010). tACS has been proposed to interact with or even entrain spontaneous brain oscillations in a frequency-dependent manner by the subthreshold modulation of membrane potentials (Teo et al, 2017).…”

Section: Transcranial Alternating Current Stimulation Parkinson's Dismentioning

confidence: 99%

“…Similarly, anodal tDCS increases neuronal excitability by reducing the resting membrane threshold of cortical neurons, while cathodal tDCS decreases neuronal excitability. In contrast, tACS delivers a rhythmic current flow that can entrain pathological brain oscillations (Ingrid et al, 2014;Teo et al, 2017). In tACS, biphasic sinusoidal alternating current is used.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

et al. 2020

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Dysfunction within large-scale brain networks as the basis for movement disorders is an accepted hypothesis. The treatment options for restoring network function are limited. Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation are now being studied to modify the network. Transcranial electrical stimulation (tES) is also a portable, cost-effective, and non-invasive way of network modulation. Transcranial direct current stimulation and transcranial alternating current stimulation have been studied in Parkinson's disease, dystonia, tremor, and ataxia. Transcranial pulsed current stimulation and transcranial random noise stimulation are not yet studied enough. The literature in the use of these techniques is intriguing, yet many unanswered questions remain. In this review, we highlight the studies using these four potential tES techniques and their electrophysiological basis and consider the therapeutic implication in the field of movement disorders. The objectives are to consolidate the current literature, demonstrate that these methods are feasible, and encourage the application of such techniques in the near future. Keywords: non-invasive brain stimulation (NIBS), transcranial electrical stimulation (tES), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial pulsed current stimulation (tPCS), transcranial random noise stimulation (tRNS)

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“…A recent paper by Janzen et al ( 2019 ) suggests vibroacoustic stimuli mimic brain stimulation (e.g., during transcranial electrical stimulation, wherein brain oscillations are induced), which in turn regulate thalamocortical dysrhythmias and enhance functional connectivity of the pain network in fibromyalgia patients. Based on this concept of neural entrainment, we may speculate that the delivery of rhythmic entrainment and sound vibration achieved with VAT can regulate abnormal neural oscillatory activity in PD (Teo et al, 2017 ). This hypothesis warrants further investigation to elaborate on the effects of vibroacoustic stimuli on neural oscillation and network connectivity.…”

Section: The Relaxation Hypothesismentioning

confidence: 99%

An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson’s Disease

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Teo

2020

Front. Aging Neurosci.

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Parkinson's disease (PD) is characterized by motor and cognitive deficits that negatively impact on activities of daily living. While dopaminergic medications are used to attenuate motor symptoms, adjuvant therapies such as acoustic-based non-pharmacological interventions are used as a complement to standard drug treatments. At present, preliminary studies of acoustic-based interventions such as rhythmic-auditory stimulation (RAS) and vibroacoustic therapy (VAT) suggest two competing hypotheses: (1) RAS may recruit alternative motor networks that may bypass faulty spatiotemporal motor networks of movement in PD; or (2) the use of RAS enhances BG function through entrainment of beta oscillatory activities. In this mini review article, we discuss the mechanisms underlying the role of acoustic-based interventions and how it may serve to improve motor deficits such as gait impairments and tremors. We further provide suggestions for future work that may use a combination of RAS, VAT, and physical therapy to improve motor function in PD.

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Transcranial Alternating Current Stimulation: A Potential Modulator for Pathological Oscillations in Parkinson’s Disease?

Cited by 8 publications

References 41 publications

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases

Non-invasive Transcranial Electrical Stimulation in Movement Disorders

An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson’s Disease

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