Transcranial alternating brain stimulation at alpha frequency reduces hemispatial neglect symptoms in stroke patients

Schuhmann, Teresa; Duecker, Felix; Spanje, Marij Middag-van; Gallotto, Stefano; Heugten, Caroline van; Schrijnemaekers, Anne-Claire; Oostenbrugge, Robert J. van; Sack, Alexander T.

doi:10.1016/j.ijchp.2022.100326

Cited by 7 publications

(8 citation statements)

References 37 publications

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“…Among the included studies, only one study highlighted an improvement in overall functional status in patients with stroke after tACS ( 21 ), and two studies investigated the effect of tACS on motor function and gait patterns ( 22 , 23 ). One study reported the efficacy of tACS on aphasia recovery ( 24 ), whereas one study evaluated the effect of tACS on hemispatial neglect ( 25 ).…”

Section: Resultsmentioning

confidence: 99%

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The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review

Yang,

Yi,

Chang

2024

Front. Neurol.

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Stroke is a common neurological disorder worldwide that can cause significant disabilities. Transcranial alternating current stimulation (tACS) is an emerging non-invasive neuromodulation technique that regulates brain oscillations and reshapes brain rhythms. This study aimed to investigate the effect of tACS on functional recovery in patients with stroke. The MEDLINE (PubMed), Cochrane Library, Embase, SCOPUS, and Web of Science databases were searched for English-language articles on tACS and stroke, published up to October 20, 2023. The following key search phrases were combined to identify potentially relevant articles: ‘tACS,’ ‘transcranial alternating current stimulation,’ ‘stroke,’ ‘cerebral infarct,’ and ‘intracerebral hemorrhage.’ The inclusion criteria for study selection were as follows: (1) studies involving patients with stroke and (2) studies that used tACS for functional recovery. A total of 34 potentially relevant studies were identified. Five articles were included in this review after reading the titles and abstracts and assessing their eligibility based on the full-text articles. Among the included studies, one investigated the improvement in overall functional status in patients with stroke after tACS, and two investigated the effect of tACS on motor function and gait patterns. Moreover, one study reported the efficacy of tACS on aphasia recovery, and one study evaluated the effect of tACS on hemispatial neglect. Our findings suggest that tACS improves functional recovery in patients with stroke. The application of tACS was associated with improved overall functional recovery, sensorimotor impairment, aphasia, and hemispatial neglect. The potential clinical application of tACS should be supported by high-quality, evidence-based studies.

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Section: Resultsmentioning

confidence: 99%

“…The application of tACS may be recommended, considering the efficacy of stimulation in stroke recovery and its several advantages. First, tACS is usually well-tolerated and is both feasible and inexpensive ( 25 ). Moreover, tACS can also be easily applied in the clinical setting.…”

Section: Discussionmentioning

confidence: 99%

The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review

Yang,

Yi,

Chang

2024

Front. Neurol.

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“…The CVDT measures perceptual sensitivity and attentional selection in each hemifield [28,29,37,38]. During the task, the patient is seated in front of the laptop screen at 52 cm distance.…”

Section: Computerized Visual Detection Task (Cvdt)mentioning

confidence: 99%

“…Where contrast max is 100% [29]. This variable accounts for the logarithmic nature of contrast detection, and makes trials count more when the contrast was low.…”

Section: Computerized Visual Detection Task (Cvdt)mentioning

confidence: 99%

“…This is particularly interesting in the field of neglect rehabilitation, as oscillatory activity in the alpha range (8)(9)(10)(11)(12) in posterior parietal cortices has been linked to spatial attention bias in healthy subjects [23][24][25][26][27]. In our recent studies, we showed that transcranial alternating current stimulation (tACS), applied at alpha frequency, can be used to influence visuospatial attention performance in healthy participants [28] and in sub-acute VSN patients [ 29] in a single session.…”

Section: Introductionmentioning

confidence: 99%

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Study protocol of transcranial electrical stimulation at alpha frequency applied during rehabilitation: A randomized controlled trial in chronic stroke patients with visuospatial neglect

et al. 2022

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Background A frequent post stroke disorder in lateralized attention is visuospatial neglect (VSN). As VSN has a strong negative impact on recovery in general and independence during daily life, optimal treatment is deemed urgent. Next to traditional stroke treatment, non-invasive brain stimulation offers the potential to facilitate stroke recovery as a complementary approach. In the present study, visual scanning training (VST; the current conventional treatment) will be combined with transcranial alternating current stimulation (tACS) to evaluate the additive effects of repeated sessions of tACS in combination with six-weeks VST rehabilitation. Methods In this double-blind randomized placebo-controlled intervention study (RCT), we will compare the effects of active tACS plus VST to sham (placebo) tACS plus VST, both encompassing 18 VST training sessions, 40 minutes each, during 6 weeks. Chronic stroke patients with VSN (> 6 months post-stroke onset) are considered eligible for study participation. In total 22 patients are needed for the study. The primary outcome is change in performance on a cancellation task. Secondary outcomes are changes in performance on a visual detection task, two line bisection tasks, and three measures to assess changes in activities of daily living. Assessment is at baseline, directly after the first and ninth training session, after the last training session (post training), and 1 week and 3 months after termination of the training (follow-up). Discussion If effective, a tACS-VST rehabilitation program could be implemented as a treatment option for VSN. Trial registration ClinicalTrials.gov; registration number: NCT05466487; registration date: July 18, 2022 retrospectively registered; https://clinicaltrials.gov/ct2/show/NCT05466487

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Advances in the Rehabilitation of Hemispatial Inattention

Singh

Leff

2023

Curr Neurol Neurosci Rep

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Purpose of Review There continue to be a plethora of approaches to the rehabilitation of hemispatial inattention, from different forms of sensory stimulation (visual, auditory and somatosensory feedback), through all major modes of non-invasive brain stimulation to drug therapies. Here we summarise trials published in the years 2017–2022 and tabulate their effect sizes, with the aim of drawing on common themes that may serve to inform future rehabilitative studies. Recent Findings Immersive virtual reality approaches to visual stimulation seem well tolerated, although they have yet to yield any clinically relevant improvements. Dynamic auditory stimulation looks very promising and has high potential for implementation. Robotic interventions are limited by their cost and are perhaps best suited to patients with a co-occurring hemiparesis. Regarding brain stimulation, rTMS continues to demonstrate moderate effects but tDCS studies have yielded disappointing results so far. Drugs, primarily aimed at the dopaminergic system, often demonstrate beneficial effects of a medium size, but as with many of the approaches, it seems difficult to predict responders and non-responders. Summary Our main recommendation is that researchers consider incorporating single-case experimental designs into their studies as rehabilitation trials are likely to remain small in terms of patient numbers, and this is the best way to deal with all the factors that cause large between-subject heterogeneity.

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Transcranial alternating brain stimulation at alpha frequency reduces hemispatial neglect symptoms in stroke patients

Cited by 7 publications

References 37 publications

The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review

The effect of transcranial alternating current stimulation on functional recovery in patients with stroke: a narrative review

Study protocol of transcranial electrical stimulation at alpha frequency applied during rehabilitation: A randomized controlled trial in chronic stroke patients with visuospatial neglect

Advances in the Rehabilitation of Hemispatial Inattention

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