Transcorneal Electrical Stimulation Therapy May Have a Stabilization Effect on Multifocal Electroretinography for Patients With Retinitis Pigmentosa

Yigit, Didem Dizdar; Sevik, Mehmet Orkun; Şahin, Özlem

doi:10.1097/iae.0000000000003386

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…It is used to study eye movements. During EOG, electrodes are attached to the skin on both sides of the eyes [4], [5] In this paper, our focus is on EEG signals which allow us to investigate the brain's electrical activity [6]. These are electrical, and non-electrical signals that we can capture and monitor as shown in Table 1.…”

Section: Gram (Emg) Electroretinogram (Erg) Electroencephalogram (Eeg...mentioning

confidence: 99%

Recent Trends in EEG-Based Motor Imagery Signal Analysis and Recognition: A Comprehensive Review

Sharma

Singhal

et al. 2023

IEEE Access

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The electroencephalogram (EEG) motor imagery (MI) signals are the widespread paradigms in the brain-computer interface (BCI). Its significant applications in the gaming, robotics, and medical fields drew our attention to perform a detailed analysis. However, the problem is ill-posed as these signals are highly nonlinear, unpredictable, and noisy, hence making it exceedingly hard to be analyzed adequately. This paper provides a first-of-its-kind comprehensive review of conventional signal processing and deep learning techniques for BCI MI signal analysis. The review comprises extensive works carried out in the domain in the recent past, highlighting the current challenges of the problem. A new categorization of the existing approaches has been presented for better clarification. An all-inclusive description of the signal processing techniques has been corroborated by relevant works in the area. Moreover, architectures of various standard deep learning algorithms along with their merits and demerits are also explicated to assist the readers. The tabular representations of the numerical results are also readily provided. This work also presents the open research problems and future directions.

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Section: Gram (Emg) Electroretinogram (Erg) Electroencephalogram (Eeg...mentioning

confidence: 99%

Recent Trends in EEG-Based Motor Imagery Signal Analysis and Recognition: A Comprehensive Review

Sharma

Singhal

et al. 2023

IEEE Access

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“… 1 Although there is not yet an accepted effective treatment option, successful results have been reported in recent years with gene and stem cell therapies and electrical stimulation interventions aiming to halt disease progression and regenerate the retinal cells. 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 Many of these clinical studies have included patients with advanced RP, and reliable results cannot be obtained with standard tests of visual function in such cases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field

Öner,

Kahraman

2024

tjo

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Objectives: The full-field stimulus threshold (FST) test was developed to evaluate the efficacy and safety of treatments of hereditary retinal diseases. In this study we performed the FST test in patients with retinitis pigmentosa (RP) and compared the results with findings from other ophthalmological tests. Materials and Methods: The study included 51 intermediate and advanced RP patients and 21 normal subjects. All patients and controls underwent routine examination and ophthalmological tests including visual field, optical coherence tomography, full-field and multifocal electroretinography (mfERG), and FST tests. During FST testing, the perception thresholds of retina to the white, blue, and red FST were determined in decibels. Results: The mean age of the patients and the controls were 35.2 and 33.5 years, respectively. For all RP patients, no response was obtained on full-field ERG. All subjects were able to perform reliable FST tests. The mean values of visual acuity and central macular thickness were significantly lower and visual field mean deviation values were significantly higher in the RP group than the controls. When we evaluated the mfERG findings, the mean P1 wave amplitudes in all rings were significantly lower and the mean peak times were significantly longer in RP patients than controls. In comparisons of FST test results, the mean values for white, blue, red and the difference between blue-red thresholds were significantly lower in the RP group than the control group. Conclusion: The FST test is a fast and a reliable exam which can be done in subjects with poor visual acuity and reduced visual field. The results of this study confirm that the FST test can measure retinal sensitivity in severely affected RP subjects with flat flash ERG.

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Noninvasive electrical stimulation as a neuroprotective strategy in retinal diseases: a systematic review of preclinical studies

Li,

Zhou,

Liang

et al. 2024

J Transl Med

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Background Electrical activity has a crucial impact on the development and survival of neurons. Numerous recent studies have shown that noninvasive electrical stimulation (NES) has neuroprotective action in various retinal disorders. Objective To systematically review the literature on in vivo studies and provide a comprehensive summary of the neuroprotective action and the mechanisms of NES on retinal disorders. Methods Based on the PRISMA guideline, a systematic review was conducted in PubMed, Web of Science, Embase, Scopus and Cochrane Library to collect all relevant in vivo studies on “the role of NES on retinal diseases” published up until September 2023. Possible biases were identified with the adopted SYRCLE’s tool. Results Of the 791 initially gathered studies, 21 articles met inclusion/exclusion criteria for full-text review. The results revealed the neuroprotective effect of NES (involved whole-eye, transcorneal, transscleral, transpalpebral, transorbital electrical stimulation) on different retinal diseases, including retinitis pigmentosa, retinal degeneration, high-intraocular pressure injury, traumatic optic neuropathy, nonarteritic ischemic optic neuropathy. NES could effectively delay degeneration and apoptosis of retinal neurons, preserve retinal structure and visual function with high security, and its mechanism of action might be related to promoting the secretion of neurotrophins and growth factors, decreasing inflammation, inhibiting apoptosis. The quality scores of included studies ranged from 5 to 8 points (a total of 10 points), according to SYRCLE’s risk of bias tool. Conclusion This systematic review indicated that NES exerts neuroprotective effects on retinal disease models mainly through its neurotrophic, anti-inflammatory, and anti-apoptotic capabilities. To assess the efficacy of NES in a therapeutic setting, however, well-designed clinical trials are required in the future.

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Transcorneal Electrical Stimulation Therapy May Have a Stabilization Effect on Multifocal Electroretinography for Patients With Retinitis Pigmentosa

Cited by 3 publications

References 28 publications

Recent Trends in EEG-Based Motor Imagery Signal Analysis and Recognition: A Comprehensive Review

Recent Trends in EEG-Based Motor Imagery Signal Analysis and Recognition: A Comprehensive Review

Evaluation of Full-Field Stimulus Threshold Test Results in Retinitis Pigmentosa: Relationship with Full-Field Electroretinography, Multifocal Electroretinography, Optical Coherence Tomography, and Visual Field

Noninvasive electrical stimulation as a neuroprotective strategy in retinal diseases: a systematic review of preclinical studies

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