Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk

Hsu, Fang Chi; Sides, Elizabeth G; Mychaleckyj, Josyf C.; Worrall, Bradford B.; Elias, Ghazwan; Liu, Y.; Chen, W.-M.; Coull, Bruce M.; Toole, James F.; Rich, Stephen S.; Furie, Karen L.; Sale, Michèle M.

doi:10.1212/wnl.0b013e318233b1f9

Cited by 31 publications

(31 citation statements)

References 40 publications

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“…Similarly, several large-scale clinical trials (e.g. LOOK AHEAD, DASH, and VISP) have also identified genetic factors which contribute to determining responsiveness to dietary interventions (Hsu et al, 2011; McCaffery et al, 2012; Svetkey et al, 2011). Accordingly, though extensive research remains to be conducted in this area, genetic profiling may at some point aid in the prescription of both pharmaceutical and lifestyle-based interventions for the treatment of hypertension, even in late-life.…”

Section: Future Directions – Potential Points Of Interventionmentioning

confidence: 99%

Hypertension and aging

Buford

2016

Ageing Research Reviews

409

289

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Hypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults. Traditional discussions of hypertension have largely focused on the risks for cardiovascular disease and associated events. However, there are a number of collateral effects, including risks for dementia, physical disability, and falls/fractures which are increasingly garnering attention in the hypertension literature. Several key mechanisms – including inflammation, oxidative stress, and endothelial dysfunction – are common to biologic aging and hypertension development and appear to have key mechanistic roles in the development of the cardiovascular and collateral risks of late-life hypertension. The objective of the present review is to highlight the multi-dimensional risks of hypertension among older adults and discuss potential strategies for treatment and future areas of research for improving overall care for older adults with hypertension.

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Section: Future Directions – Potential Points Of Interventionmentioning

confidence: 99%

Hypertension and aging

Buford

2016

Ageing Research Reviews

409

289

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“…Субклинический метаболический дефицит витамина B 12 , критерием которого является высокое содержание в плазме крови метилмалоновой кислоты и снижение содержания в сыворотке крови уровня витамина В 12 менее 400 пкмоль/л, встречается достаточно часто, особенно у лиц пожилого возраста [24]. Согласно результатам анализа по подгруппам, в РКИ выдвинута гипотеза, что более высокие дозы витамина B 12 (напри-мер, 1 мг/сут -успешно используемая дозировка с целью профилактики развития инсульта в испытании HOPE -Heart Outcomes Prevention Evaluation 2 [25]), позволят существенно снизить содержание гомоцисте-ина и риск развития инсульта, особенно у лиц, потреб-ляющих достаточное количество фолиевой кислоты, но испытывающих дефицит витамина В 12 [24][25][26][27][28][29][30]. Эта гипотеза требует подтверждения в клинических испы-таниях.…”

Section: витамины группы вunclassified

Vitamin Supplementation and Stroke Prevention

Hankey

2012

Stroke

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“…[48] Several studies suggest a positive and dose-dependent association between the serum concentration of total homocysteine and the risk of stroke, which is independent of other vascular risk factors. [49] Mutations in genes of the homocysteine metabolic pathway may confer an increased risk for ischemic stroke because of elevated plasma homocysteine levels. A study carried out by Alluri et al in a South Indian population found that C677T MTHFR mutation is strongly associated with arterial stroke, especially in young adults and concluded that MTHFR allele evaluation will help in preventing/reducing morbidity caused by stroke.…”

Section: Genes Involved In Homocysteine Metabolismmentioning

confidence: 99%