Transcatheter intra-arterial infusion of doxorubicin loaded porous magnetic nano-clusters with iodinated oil for the treatment of liver cancer

Abstract

A promising strategy for liver cancer treatment is to deliver chemotherapeutic agents with multifunctional carriers into the tumor tissue via intra-arterial (IA) transcatheter infusion. These carriers should release drugs within the target tissue for prolonged periods and permit intra-procedural multi-modal imaging of selective tumor delivery. This targeted transcatheter delivery approach is enabled via the arterial blood supply to liver tumors and utilized in current clinical practice which is called chemoembolization or radioembolization. During our study, we developed Doxorubicin (Dox) loaded porous magnetic nano-clusters (Dox-pMNCs). The porous structure and carboxylic groups on the MNCs achieved high-drug loading efficiency and sustained drug release, along with magnetic properties resulting in high MRI T2-weighted image contrast. Dox-pMNC within iodinated oil, Dox-pMNCs, and Dox within iodinated oil were infused via hepatic arteries to target liver tumors in a rabbit model. MRI and histological evaluations revealed that the long-term drug release and retention of Dox-pMNCs within iodinated oil induced significantly enhanced liver cancer cell death.

Biofunctionalized Hybrid Magnetic Gold Nanoparticles as Catalysts for Photothermal Ablation of Colorectal Liver Metastases

“…These findings reinforce the selective nature of antibody-coated HNPs to reach receptorpositive cells, as shown in a recent study (38). Furthermore, cytotoxicity of anti-MG1 HNPs was analogous to the cell viability data of different iron oxide nanoparticles in our previous study (33) or polymer-coated iron oxide nanoparticles (39) and hybrid gold-iron oxide nanoparticles reported in other studies (40). These results also support prior observations on changes in particle size, and the gold shell had minimal effect on the cytotoxicity profiles of HNPs (40).…”

“…Therefore, we focused our efforts on bolstering the tumor-specific delivery of nanoparticles and on performing targeted PTA while concurrently exploring different imaging modalities. We and other groups have shown that iron oxide-based nanomaterial is suitable to monitoring targeted delivery of therapeutics in preclinical liver tumor models (33,34). Methods to engineer magnetic nanoparticles for the development of new drug and delivery platforms are under intense investigation (35).…”

pH‐Responsive PEG–Doxorubicin‐Encapsulated Aza‐BODIPY Nanotheranostic Agent for Imaging‐Guided Synergistic Cancer Therapy

“…AB NPs also showed higher photo cytotoxicity (IC 50 ≈6.0 µg mL −1 , equivalent to aza‐BODIPY concentration) than its dark toxicity (with 70% cell viability at the concentration of 8 µg mL −1 , equivalent to aza‐BODIPY concentration). The cytotoxicity of free DOX was the highest among these materials (with IC 50 ≈1.8 µg mL −1 , equivalent to DOX concentration), which could be ascribed to DOX's easy diffusion through cellular membrane, thereby resulting in opening the antitumor function of free DOX . All the results indicate that both DAB NPs and AB NPs possess high photo cytotoxicity, low dark cytotoxicity and good biocompatibility in HeLa cells.…”

Nanomedicines: a theranostic approach for hepatocellular carcinoma

“…These results suggest that the sustained release of Dox pMNCs can be significantly potentiated by lipiodol for increased retention. Finally, MRI and histological evaluations revealed that the long-term drug release and retention of Dox-pMNCs within iodinated oil significantly enhanced liver cancer cell death [31].…”