Transcatheter Closure of Membranous Ventricular Septal Defects—Old Problems and New Solutions

Butera, Gianfranco; Piazza, Luciane; Saracino, Antonio; Chessa, Massimo; Carminati, Mário

doi:10.1016/j.iccl.2012.09.003

Cited by 6 publications

(4 citation statements)

References 38 publications

(87 reference statements)

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“…However, transcatheter device closure was limited by potential vascular injury and exposure to X-rays. There were also technical challenges when applied to infants or patients with a weight below 10 kg [19]. Under these conditions, intraoperative device closure of VSD developed from the above two treatments.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life in children and adolescents undergoing intraoperative device closure of isolated perimembranous ventricular septal defects in southeastern China

Huang

Kim

et al. 2019

J Cardiothorac Surg

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ObjectivesTo investigate the health-related quality of life (HRQOL) in children and adolescents who underwent intraoperative device closure of perimembranous ventricular septal defects (pmVSDs).MethodsFrom October 2017 to January 2018, a total of 126 children and adolescents with isolated pmVSDs who underwent intraoperative device closure were enrolled in this study. We used the Pediatric Quality of Life Inventory Measurement Models 4.0 generic core scales to measure HRQOL 24 h before the operation and three months and one year after surgery.ResultsA total of 126 patients were successfully occluded. No severe complications occurred during the operative time, and 1 case of Mobitz type I atrioventricular block (AVB) and 1 case of complete cAVB occurred during the postoperative period. Compared with the data before the operation, the total score and five domain scores, including physical, psychosocial, emotional, social and psychological functioning, were significantly higher at three months after the operation. In addition, the total score, physical functioning score, and the psychosocial functioning score at the 1-year follow-up were even higher than those at 3 months after the operation.ConclusionsThe present study suggests that intraoperative device closure of pmVSD could improve health-related quality of life in children/adolescents and that the improvement may progress as the time after the operation increases. Further studies should concentrate on comparisons with other medical methods, larger samples, and longer follow-up periods.

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Section: Discussionmentioning

confidence: 99%

Health-related quality of life in children and adolescents undergoing intraoperative device closure of isolated perimembranous ventricular septal defects in southeastern China

Huang

Kim

et al. 2019

J Cardiothorac Surg

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“…In addition, there were still technical challenges when the device was applied in infants or patients with a weight less than 10 kg. Furthermore, the relatively high price of an occluder may limit the promotion of this approach in developing countries [18][19][20].…”

Section: Commentmentioning

confidence: 99%

Intraoperative Device Closure of Isolated Ventricular Septal Defects: Experience on 1,090 Cases

Chen

Hong

Zhang

et al. 2018

The Annals of Thoracic Surgery

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“…This study is undoubtedly hampered by several limitations: (1) the study was of a single centre retrospective design and therefore contingent on the inherent bias associated with this type of study (missing data; referral and selection bias); (2) over the period examined , the majority of surgical procedures were delayed compared with current standard decision making and a smaller number of interventional perimembranous ventricular septal defect closures were performed [37]. This may have slightly influenced our findings; (3) other unevaluated factors of an epigenetic nature might have influenced the results [38].…”

Section: Discussionmentioning

confidence: 99%

Does Oxygen Content Play a Role in Spontaneous Closure of Perimembranous Ventricular Septal Defects?

et al. 2021

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(1) Background: the impact of a series of laboratory parameters (haemoglobin, haematocrit, foetal haemoglobin, peripheral oxygen saturation, iron, transferrin, ferritin, and albumin) on perimembranous ventricular septal defects spontaneous healing was tested. (2) Methods: one hundred and seven patients were enrolled in the study (57% males; mean age 2.1 ± 0.4 years) and were subsequently subdivided into two groups: self-healing (n = 36) and in need of intervention (n = 71). Self-healing subjects were defined on the basis of an absence of residual shunts at colorDoppler across the previous defect. (3) Results: no statistically significant differences were reported in the size of perimembranous ventricular septal defects between the two groups (p = ns). Conversely, prevalence of anaemia was significantly higher in those requiring intervention than in the self-healing group (p < 0.03), while haemoglobin, iron, ferritin, and albumin levels were lower (p < 0.001, p < 0.05, p < 0.02, p < 0.007, respectively). In multivariable linear regression analysis, only haemoglobin and albumin were found to be associated with spontaneous closure (p < 0.005 and p < 0.02, respectively). In multiple logistic regression analysis, haemoglobin independently increased the probability of self-healing of perimembranous ventricular septal defects (p = 0.03). All patients needing an interventional closure of perimembranous ventricular septal defects presented with haemoglobin <12.7 g/dL. (4) Conclusion: the self-resolution of perimembranous ventricular septal defects seems to rely on numerous factors, including oxygen content, which is likely to promote cell proliferation as well as tissue regeneration. Haemoglobin blood concentration seems to influence the natural history of perimembranous ventricular septal defects and improvement of anaemia by supplementation of iron intake might represent a simple and reliable method to promote self-healing.

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Transcatheter Closure of Membranous Ventricular Septal Defects—Old Problems and New Solutions

Cited by 6 publications

References 38 publications

Health-related quality of life in children and adolescents undergoing intraoperative device closure of isolated perimembranous ventricular septal defects in southeastern China

Health-related quality of life in children and adolescents undergoing intraoperative device closure of isolated perimembranous ventricular septal defects in southeastern China

Intraoperative Device Closure of Isolated Ventricular Septal Defects: Experience on 1,090 Cases

Does Oxygen Content Play a Role in Spontaneous Closure of Perimembranous Ventricular Septal Defects?

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