“…In fact, among cases with confirmed significant CAD, those with high SYNTAX score had an increased risk of cardiovascular mortality, stroke, and myocardial infarction at 1 year follow-up compared to those with low SYNTAX score or no CAD (no CAD: 13%, low SYNTAX score: 16%, high SYNTAX score: 30%; p = 0.02) [3]. Unlike coronary artery bypass grafting (CABG) at the time of SAVR, PCI among patients undergoing TAVI appears to confer no excess short-term risk of death, myocardial infarction, and stroke compared with isolated TAVI [2,4,5] although there is no agreement about the real need for treating coronary stenosis before, or after TAVI in the absence of clear signs of ischemia. Such indication may be better addressed by assessing the clinical need dictated by symptoms during follow-up.…”