Transcapillary Escape Rate of Albumin and Plasma Volume in Short- and Long-Term Juvenile Diabetics

Hh, Parving; Sm, Rasmussen

doi:10.3109/00365517309082454

Cited by 102 publications

(45 citation statements)

References 18 publications

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“…13 In addition, diabetic microangiopathy is accompanied by increased microvascular permeability to various substances, including plasma protein. 14,15 Our results, in which diabetic patients had a 90% increased risk of high peritoneal transport status, were consistent with the above-mentioned findings. It is controversial whether or not age affects the peritoneal membrane permeability.…”

Section: Discussionsupporting

confidence: 91%

Risk factor(s) related to high membrane permeability in peritoneal dialysis

et al. 2015

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Aim: Peritoneal dialysis (PD) patients have different peritoneal membrane permeability (transport) characteristics. High peritoneal membrane permeability is associated with increased mortality risk in the patient population. In this study, we aimed to investigate possible risk factor(s) related to high peritoneal membrane permeability. Patients and method: The study included 475 PD patients (46.1 ± 14.5 years of mean age; 198 female and 277 male). The patients were divided two groups according to peritoneal equilibration test (PET) result: high-permeability group (high and highaverage) and low-permeability group (low-average and low). Results: In both the univariate and multivariate logistic regression analyses, it was found that diabetes mellitus and hypoalbuminemia was significantly associated with high peritoneal membrane permeability [relative risk (RR): 1.90, 95% confidence interval (CI): 1.26-2.86, p: 0.002 and RR: 2.14, 95% CI: 1.44-3.18, p50.001, respectively]. Conclusion: Diabetes mellitus and hypoalbuminemia were closely associated with high peritoneal membrane permeability. Diabetic patients had 1.9 times the likelihood of having high permeability. However, the relationship between hypoalbuminemia and high peritoneal permeability appears to be a result rather than cause. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 91%

Risk factor(s) related to high membrane permeability in peritoneal dialysis

et al. 2015

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“…Several studies in IDDM patients with abnormally elevated urinary albumin excretion rate have demonstrated raised values of: transcapillary escape of albumin (TER alb ) [3][4][5][6]; plasma von Willebrand factor (vWF) [7,8]; plasma prorenin activity [9][10][11][12]; and angiotensin-converting enzyme activity [13]. Reduced release of tissue plasminogen activator has also been demonstrated in the above mentioned patients [14].…”

Section: Discussionmentioning

confidence: 99%

“…This is crucial since approximately 25 % of albuminuric NIDDM patients are suffering from a nondiabetic glomerulopathy [18]. Previous studies in IDDM patients with abnormally elevated urinary albumin excretion rate with or without diabetic retinopathy have documented raised TER alb [3][4][5][6], vWF [7,8], and plasma prorenin [9,11,12].…”

Section: Discussionmentioning

confidence: 99%

Macro-microangiopathy and endothelial dysfunction in NIDDM patients with and without diabetic nephropathy

et al. 1996

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Insulin-dependent diabetic (IDDM) patients with incipient and overt diabetic nephropathy are characterized by a higher incidence and prevalence of retinopathy and cardiovascular diseases than normoalbuminuric IDDM patients [1,2]. The relative cardiovascular mortality is approximately 40 times higher in diabetic nephropathy as compared to the age-matched population [1]. Furthermore, the prevalence of

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“…This could be explained by an increased capillary permeability in our diabetics. With regard to this possibility, there is evidence to show that diabetes is associated with increased permeability and increased hydrostatic pressure in the microcirculation, resulting in an abnormal extravasation of plasma proteins (45). Increased transcapillary escape rates of albumin and globulins have been found both in long-term diabetics (45) and, more recently, in short-term juvenile diabetics in poor metabolic control (46), and have been connected with diabetic microangiopathy.…”

Section: Discussionmentioning

confidence: 99%

Kinetic Analysis of Plasma Insulin Disappearance in Nonketotic Diabetic Patients and in Normal Subjects

Navalesi¹,

Pilo²,

Ferrannini³

et al. 1978

J. Clin. Invest.

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A B S T R A C Tson with normals (172 +14); these differences reflected the different basal plasma insulin concentrations in these three groups. Chronic treatment with oral hypoglycemic drugs, age, duration of the disease, and degree of metabolic control appeared to have only little effect on the kinetics of insulin. On the basis of these results, we conclude that insulin-independent adult diabetics show, already in the fasting state, a combination of insulin resistance and insulin deficiency and a derangement in insulin distribution, the precise significance of which is uncertain.

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Transcapillary Escape Rate of Albumin and Plasma Volume in Short- and Long-Term Juvenile Diabetics

Cited by 102 publications

References 18 publications

Risk factor(s) related to high membrane permeability in peritoneal dialysis

Risk factor(s) related to high membrane permeability in peritoneal dialysis

Macro-microangiopathy and endothelial dysfunction in NIDDM patients with and without diabetic nephropathy

Kinetic Analysis of Plasma Insulin Disappearance in Nonketotic Diabetic Patients and in Normal Subjects

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