Transcanal Endoscopic Retrograde Mastoidectomy for Cholesteatoma: A Prospective Study

Shakya, Dipesh; Nepal, Ajit

doi:10.1177/01455613211009439

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Currently, the only effective method of treating cholesteatoma is the complete removal and repair of the damaged middle ear structures, and various surgical accesses are used for this purpose [21][22][23]. Unfortunately, recurrence after surgery is still common, and risk factors for recurrence include young age, cholesteatoma localized to the mastoid, stapes, or incus erosion [3].…”

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confidence: 99%

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Dżaman,

Czerwaty,

Reichert

et al. 2023

IJMS

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Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.

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Section: Introductionmentioning

confidence: 99%

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Dżaman,

Czerwaty,

Reichert

et al. 2023

IJMS

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A retrospective study of audiological outcomes after endoscopic tympanoplasty and tympanomastoidectomy in patients with cholesteatoma

Tang

Gao²,

Zhang³

et al. 2023

Asian Journal of Surgery

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Comparative assessment of computed tomography and magnetic resonance imaging in the identification of the middle ear cholesteatoma

Степанова

Garov

2023

Almanac of Clinical Medicine

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Background: Chronic suppurative otitis media amounts up to 22.4% among all ear, nose and throat disorders. Its complication, a middle ear cholesteatoma, is one of the most frequent causes of patients' referral to an otologist. The literature on the preferential diagnostic method for the cholesteatoma is contradictory, despite that its main treatment approach is surgery. Therefore, it is important to identify the most valid diagnostic method, which would allow for the planning of the most effective surgical treatment. Aim: To compare sensitivity and specificity of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of cholesteatoma, to assess the possibility of quantitative values of MRI diffusion limitation in cholesteatoma. Materials and methods: From 2015 to 2021, we examined 542 out- and in-patients (849 imagings of temporal bones) with chronic suppurative otitis media. The analysis of CT and MRI sensitivity and specificity included the data from 289 patient examinations, both with newly diagnosed cholesteatoma and having at least one past surgery and had their diagnosis verified intraoperatively and histologically. We analyzed the measured MRI diffusion coefficients from newly diagnosed and relapsed cholesteatoma. The MRI signal values were calculated for 266 masses from 238 patients. Results: MRI sensitivity for the diagnosis of cholesteatoma was 95.2%, specificity 81.2%. CT sensitivity and specificity for the diagnosis of cholesteatoma were 60.1 и 44.7%, respectively. There were no differences in the measured MRI diffusion coefficients between the relapsed and newly diagnosed cholesteatomas. The comparison of cholesteatoma signals with those from artifacts showed the overlapping in their mean values; therefore, it is impossible to rely only on the value of the diffusion coefficient. Conclusion: In the diagnosis of cholesteatomas, MRI is significantly more sensitive and specific than CT. No significant differences in MRI semiotics and the degree of MRI diffusion limitation at NON-EPI DWI (b1000) have been found for the cholesteatomas that had never been operated, and the relapsing cholesteatomas.

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Transcanal Endoscopic Retrograde Mastoidectomy for Cholesteatoma: A Prospective Study

Cited by 3 publications

References 38 publications

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

A retrospective study of audiological outcomes after endoscopic tympanoplasty and tympanomastoidectomy in patients with cholesteatoma

Comparative assessment of computed tomography and magnetic resonance imaging in the identification of the middle ear cholesteatoma

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