Transcanal Endoscopic Ear Surgery for the Management of Congenital Ossicular Fixation

Zhu, Vivian F.; Kou, Yann Fuu; Lee, Kenneth H.; Kutz, Joe Walter; Isaacson, Brandon

doi:10.1097/mao.0000000000001154

Cited by 33 publications

(35 citation statements)

References 16 publications

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“…Proponents of endoscopic approach for primary stapes surgery cite enhanced visualization of the oval window and ossicles, with resultant improvement in diagnostic accuracy, as a primary advantage of the approach . These same advantages apply to revision stapes surgery for surgeons already routinely performing totally endoscopic stapes surgery.…”

Section: Discussionmentioning

confidence: 99%

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Audiologic and surgical outcomes in endoscopic revision stapes surgery

et al. 2019

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Section: Discussionmentioning

confidence: 99%

“…An endoscopic approach to stapes surgery allows for enhanced visualization of the ossicular chain and oval window . Additionally, endoscopy of the middle ear has been especially useful in diagnosing ossicular malformations, perilymphatic fistulas, and ossicular fixation …”

Section: Introductionmentioning

confidence: 99%

Audiologic and surgical outcomes in endoscopic revision stapes surgery

et al. 2019

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“…The number of subjects collected for meta‐analysis was 1004, including 513 patients belonging to EES and 491 patients under MES, and the included studies were published between 2015 and 2017. Nineteen studies were analyzed qualitatively, which were all case series studies, except for one retrospective cohort study (Table ) . The included studies were published between 1995 and 2017, and a total of 406 patients were evaluated.…”

Section: Resultsmentioning

confidence: 99%

Comparison of endoscopic and microscopic ear surgery in pediatric patients: A meta‐analysis

et al. 2018

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Objectives Recently, the endoscope has been increasingly introduced for middle‐ear surgery. To evaluate the postoperative outcomes of endoscopic ear surgery (EES) in pediatric patients, we did a qualitative analysis with a systematic review and quantitative analysis with meta‐analysis of available literature. Methods Studies reporting the comparative surgical outcomes of EES in pediatric patients were systematically reviewed by searching the MEDLINE, PubMed, and Embase databases from database inception through 2017. The selected articles included clinical studies conducted with at least 30 subjects and at least one postoperative parameter, including residual or recurrent cholesteatoma and graft success in tympanoplasty. Two investigators independently reviewed all studies and extracted the data using a standardized form. A meta‐analysis was performed using a random‐effects model and qualitative review was performed on the smaller studies. Results Ten studies were identified as appropriate for quantitative meta‐analysis and 19 studies for qualitative analysis. In the meta‐analysis, residual or recurrence rate of cholesteatoma was significantly lower in the EES group than in the microscopic ear surgery (MES) group (odds ratio [OR]: 0.56, 95% confidence interval [CI]: 0.38‐0.84, P = .005). The graft success rate of tympanoplasty was not statistically different between EES and MES groups (OR: 0.72, 95% CI: 0.41‐1.26, P = .249). In the qualitative analysis, most of the studies reported similar audiological outcomes after tympanoplasty and success rate of cholesteatoma removal between the two groups. Conclusions It appears that EES reduces the risk of residual cholesteatoma in children and that the success of perforation closure is equivalent to MES. Laryngoscope, 129:1444–1452, 2019

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“…1,2 Although endoscopic sinus surgery has become a standard technique, endoscopic ear surgery has developed relatively late due to associated disadvantages, such as one-hand surgery, lack of depth, spatial limits of the ear canal, and potential of heat injury from the instruments. 1,3,4 However, recent advances, such as endoscope holders and increased resolution of endoscopic cameras, have overcome many technical problems. Moreover, successful outcomes of endoscopic ear surgery have been reported and compared to those of conventional surgery using a microscope.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, successful outcomes of endoscopic ear surgery have been reported and compared to those of conventional surgery using a microscope. 4 Minimal invasiveness being one of the important requirements in almost all surgical fields, the demand for endoscopic ear surgery is expected to increase significantly in the future.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Ototoxicity of an Antifog Agent and the Suspected Underlying Mechanisms: An Animal Study

et al. 2019

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Use of rigid endoscopes has become widespread in middle ear surgeries, thereby attracting attention to the safety of antifog agents. However, few studies on the ototoxicity of antifog agents have been conducted. The purpose of this study was to evaluate hair cell damage and the underlying mechanisms caused by antifog agents using zebrafish larvae. We exposed zebrafish larvae at 3 days postfertilization to various concentrations of the antifog agent, Ultrastop (0.01, 0.02, 0.04, and 0.08%) for 72 hours. The average number of hair cells within 4 neuromasts of larvae, including supraorbital (SO1 and SO2), otic (O1), and occipital (OC1), in the control group were compared to those in the exposure groups. Significant hair cell loss was observed in the experimental groups compared to that in the control group (P < .01; control: 53.88 + 4.85, 0.01%: 45.08 + 11.70, 0.02%: 41.36 + 12.00, 0.04%: 35.36 + 16.18, and 0.08%: 15.60 + 7.53 cells). Concentration-dependent increase in hair cell apoptosis by terminal deoxynucleotidyltransferase (TDT)-mediated dUTP-biotin nick end labeling assay (control: 0.00 + 0.00, 0.01%: 3.48 + 2.18, 0.02%: 9.64 + 5.75, 0.04%: 17.72 + 6.26, and 0.08%: 14.60 + 8.18 cells) and decrease in the viability of hair cell mitochondria by 2-(4-[dimethylamino] styryl)-N-ethylpyridinium iodide assay (control: 9.61 + 1.47, 0.01%: 8.28 + 2.22, 0.02%: 8.45 + 2.72, 0.04%: 7.25 + 2.44, and 0.08%: 6.77 + 3.26 percentage of total area) were observed. Antifog agent exposure can cause hair cell damage in zebrafish larvae, possibly by induction of mitochondrial damage with subsequent apoptosis of hair cells.

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Transcanal Endoscopic Ear Surgery for the Management of Congenital Ossicular Fixation

Cited by 33 publications

References 16 publications

Audiologic and surgical outcomes in endoscopic revision stapes surgery

Audiologic and surgical outcomes in endoscopic revision stapes surgery

Comparison of endoscopic and microscopic ear surgery in pediatric patients: A meta‐analysis

Evaluation of Ototoxicity of an Antifog Agent and the Suspected Underlying Mechanisms: An Animal Study

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