Transcallosal inhibition and motor conduction studies in patients with schizophrenia using transcranial magnetic stimulation

Boroojerdi, Babak; Töpper, Rudolf; Foltys, Henrik; Meincke, Ulrich

doi:10.1192/bjp.175.4.375

Cited by 72 publications

(64 citation statements)

References 24 publications

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“…Reduced IHI 10 at rest has been a consistent finding in both medicated and unmedicated chronic SCZ. 29,37,44,69 In contrast, studies have also consistently found increased iSP in medicated and unmedicated chronic SCZ, 37,44,45,70,71 although not in first-degree relatives. 51 As IHI 10 and iSP are mediated by different neuronal populations, these divergent findings are likely to reflect separate pathological mechanisms.…”

Section: Interhemispheric Cortical Connectivitymentioning

confidence: 86%

Cortical Inhibition, Excitation, and Connectivity in Schizophrenia: A Review of Insights From Transcranial Magnetic Stimulation

Rogasch

Daskalakis

Fitzgerald

2013

Schizophrenia Bulletin

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Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/ inhibition on cortical oscillations in SCZ.

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Section: Interhemispheric Cortical Connectivitymentioning

confidence: 86%

Cortical Inhibition, Excitation, and Connectivity in Schizophrenia: A Review of Insights From Transcranial Magnetic Stimulation

Rogasch

Daskalakis

Fitzgerald

2013

Schizophrenia Bulletin

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“…98 Relevant to the same issue is the preliminary finding of increased interhemispheric conduction time as estimated by the latency of the transcallosal inhibition of motor response of the first dorsal interossus muscle in 10 S patients. 100 Patients were found to have an interhemispheric conduction time of 15.3 vs 12.4 ms in controls. The duration of inhibition was also increased.…”

Section: Morphological Studiesmentioning

confidence: 99%

“…For example, four times more axons were counted electron microscopically than light microscopically in the cat. 100 Therefore, a decrease in the size of callosal axons in S could be mistakenly interpreted as a loss of axons. Furthermore, it is unclear if the counts should be corrected for brain size, because there are no robust reasons to expect that the number of callosal axons increases with brain size.…”

Section: Morphological Studiesmentioning

confidence: 99%

Schizophrenia, neurodevelopment and corpus callosum

2003

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The Zeitgeist favors an interpretation of schizophrenia as a condition of abnormal connectivity of cortical neurons, particularly in the prefrontal and temporal cortex. The available evidence points to reduced connectivity, a possible consequence of excessive synaptic pruning in development. A decreased thalamic input to the cerebral cortex appears likely, and developmental studies predict that this decrease should entail a secondary loss of both longand short-range cortico-cortical connections, including connections between the hemispheres. Indeed, morphological, electrophysiological and neuropsychological studies over the last two decades suggest that the callosal connections are altered in schizophrenics. However, the alterations are subtle and sometimes inconsistent across studies, and need to be investigated further with new methodologies.

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“…Patients with prominent negative symptoms often exhibit reduced activation in frontal brain regions, a state known as hypoactivation [3]. As normal control subjects [6]. It also reported longer transcallosal suppression of motor contractions in schizophrenia group compared with healthy subjects, although no change in the latency of effect was observed.…”

Section: Cortical Excitability and Inhibition Abnormalities In Schizomentioning

confidence: 97%

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Sayar¹,

Bulut²,

Tarhan³

2015

J Neurol Neurol Sci Disord

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Transcallosal inhibition and motor conduction studies in patients with schizophrenia using transcranial magnetic stimulation

Abstract: Magnetic motor conduction parameters are unaltered in schizophrenia, but transcallosal inhibition is significantly delayed and prolonged. This may indicate abnormal function of the corpus callosum in these patients.

Cited by 72 publications

References 24 publications

Cortical Inhibition, Excitation, and Connectivity in Schizophrenia: A Review of Insights From Transcranial Magnetic Stimulation

Cortical Inhibition, Excitation, and Connectivity in Schizophrenia: A Review of Insights From Transcranial Magnetic Stimulation

Schizophrenia, neurodevelopment and corpus callosum

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

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