Abstract:PurposeIn this cross-sectional, proof-of-concept study, we propose that using the more pathologically-specific neurite orientation dispersion and density imaging (NODDI) method, in conjunction with high-resolution probabilistic tractography, white matter tract templates can improve the assessment of regional axonal injury and its association with disability of people with multiple sclerosis (pwMS).MethodsParametric maps of the neurite density index, orientation dispersion index, and the apparent isotropic volu… Show more
“…Additionally, patients experience a wide range of motor deficits, such as gait and balance difficulties due to progressive motor impairments associated with demyelination of the corticospinal tract [ 7 ]. Injury to the corticospinal tract produces weakness and spasticity, and with motor neuron involvement, can lead to muscle atrophy [ 7 ]. These symptoms arise due to the widespread neuronal degeneration within the CNS, spinal cord tracts, and peripheral nerves.…”
A systematic review was employed utilizing Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, to analyze all primary clinical data on the efficacy of spinal cord stimulation (SCS) in the treatment of multiple sclerosis (MS) induced spasticity. Databases include: Embase, PubMed, Scopus, Cochrane, and Web of Science. The review included case series, case studies, and clinical trials. Outcomes of interest were spasticity reduction. Grading of Recommendations Assessment, Development and Evaluation criteria was utilized to grade the certainty of evidence. Five hundred thirty-two articles were retrieved following database systematic review. One hundred eighty-eight articles were removed as duplicates utilizing the “Detect Duplicates” function on Rayyan.ai. A further 344 articles were excluded following abstract and title appraisal. As a result, 16 articles were subjected to full text appraisal. The dates of publication ranged from 1973 to 2019. Although a unique modality, there is not enough evidence to support the employment of SCS over current medical standard of care. Further high-quality randomized control trials are required to elucidate SCS’s role in MS induced spasticity algorithm.
“…Additionally, patients experience a wide range of motor deficits, such as gait and balance difficulties due to progressive motor impairments associated with demyelination of the corticospinal tract [ 7 ]. Injury to the corticospinal tract produces weakness and spasticity, and with motor neuron involvement, can lead to muscle atrophy [ 7 ]. These symptoms arise due to the widespread neuronal degeneration within the CNS, spinal cord tracts, and peripheral nerves.…”
A systematic review was employed utilizing Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, to analyze all primary clinical data on the efficacy of spinal cord stimulation (SCS) in the treatment of multiple sclerosis (MS) induced spasticity. Databases include: Embase, PubMed, Scopus, Cochrane, and Web of Science. The review included case series, case studies, and clinical trials. Outcomes of interest were spasticity reduction. Grading of Recommendations Assessment, Development and Evaluation criteria was utilized to grade the certainty of evidence. Five hundred thirty-two articles were retrieved following database systematic review. One hundred eighty-eight articles were removed as duplicates utilizing the “Detect Duplicates” function on Rayyan.ai. A further 344 articles were excluded following abstract and title appraisal. As a result, 16 articles were subjected to full text appraisal. The dates of publication ranged from 1973 to 2019. Although a unique modality, there is not enough evidence to support the employment of SCS over current medical standard of care. Further high-quality randomized control trials are required to elucidate SCS’s role in MS induced spasticity algorithm.
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