Transbronchial Techniques for Lung Cancer Treatment: Where Are We Now?

Chan, Jimmy Yu‐Wai; Siu, Ivan C. H.; Chang, Artemis; Li, Molly S. C.; Lau, Rainbow W. H.; Mok, Tony S. K.; Ng, Calvin S.H.

doi:10.3390/cancers15041068

Cited by 10 publications

(10 citation statements)

References 59 publications

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“…We have even the capability of making tunnels through the lung parenchyma with needles and balloon dilation and obtain sample 18 , 19 . This method is safe and effective when navigation systems are used such as the Archimedes Virtual Bronchoscopy Navigation (VBN) (Figure 3 ), Illumisite TM platform from Medronic 20 . Another novel navigation technique is the robotic assisted navigation with the Monarch ® Platform (Auris Health, Inc., Redwood City, CA) 8 .…”

Section: Methodsmentioning

confidence: 99%

Ablation for Single Pulmonary Nodules, Primary or Metastatic. Εndobronchial Ablation Systems or Percutaneous

Zarogoulidis,

Papadopoulos,

Perdikouri

et al. 2024

J. Cancer

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Single pulmonary nodules are a difficult to diagnose imagining artifact. Currently novel diagnostic tools such as Radial-EBUS with or not C-ARM flouroscopy, electromagnetic navigation systems, robotic bronchoscopy and cone beam-compuer tomography (CBCT) can assist in the optimal guidance of biopsy equipment. After diagnosis of lung cancer or metastatic disease as pulmonary nodule, then surgery or ablation methods as local treatment can be applied. The percutaneous ablation systems under computed tomography guidance with radiofrequency, microwave, cryo and thermosphere have been used for several years. In the past 10 years extensive research has been made for endobronchial ablation systems and methods. We will present and comment on the two different ablation methods and present up to date data.

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Section: Methodsmentioning

confidence: 99%

Ablation for Single Pulmonary Nodules, Primary or Metastatic. Εndobronchial Ablation Systems or Percutaneous

Zarogoulidis,

Papadopoulos,

Perdikouri

et al. 2024

J. Cancer

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“…6). Accuracy of ENB localization has been reported to be as high as 94−100% in some previous cohorts [72,73,74 ▪ ].…”

Section: The State-of-art Of Bronchoscopic Microwave Ablationmentioning

confidence: 99%

“…There were two cases of bronchopleural fistula, which were effectively treated with an endobronchial valve. The mean hospital stay was 1.73 days, while most patients (76.7%) were discharged on day one after ablation [68 ▪▪ ,74 ▪ ] (Table 2).…”

Section: The State-of-art Of Bronchoscopic Microwave Ablationmentioning

confidence: 99%

“…It is important to note that BMWA requires GA [107], therefore, patients at higher GA risk may be better suited for the percutaneous approach. BMWA particularly with more advanced robotic bronchoscopy platforms and transbronchial access tools like the CrossCountry (Medtronic Inc., USA) allow peripheral and lesions outside the bronchus to be accessed [74 ▪ ,102]. In the percutaneous approach, certain parts of the lung may be difficult or dangerous to access, such as lung shielded by the scapula, near the mediastinum, or near the diaphragm [74 ▪ ].…”

Section: Limitations Of Bronchoscopic Microwave Ablationmentioning

confidence: 99%

“…BMWA particularly with more advanced robotic bronchoscopy platforms and transbronchial access tools like the CrossCountry (Medtronic Inc., USA) allow peripheral and lesions outside the bronchus to be accessed [74 ▪ ,102]. In the percutaneous approach, certain parts of the lung may be difficult or dangerous to access, such as lung shielded by the scapula, near the mediastinum, or near the diaphragm [74 ▪ ]. Despite this, anatomical restriction for BMWA exists, for example close to the mediastinum, not of access but of risk of injury to surrounding major vessels during catheter manipulation and ablation, thermal injury to the phrenic nerve, and the raised likelihood of heat sink effect.…”

Section: Limitations Of Bronchoscopic Microwave Ablationmentioning

confidence: 99%

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Treatment strategies for malignant pulmonary nodule: beyond lobectomy. Point-counterpoint

Chang,

Ng,

Nezami

2023

Current Opinion in Pulmonary Medicine

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Purpose of review Technological advancement in low-dose computed tomography resulted in an increased incidental discovery of early-stage lung cancer and multifocal ground glass opacity. The demand for parenchyma-preserving treatment strategies is greater now than ever. Pulmonary ablative therapy is a groundbreaking technique to offer local ablative treatment in a lung-sparing manner. It has become a promising technique in lung cancer management with its diverse applicability. In this article, we will review the current development of ablative therapy in lung and look into the future of this innovative technique. Recent findings Current literature suggests that ablative therapy offers comparable local disease control to other local therapies and stereotactic body radiation therapy (SBRT), with a low risk of complications. In particular, bronchoscopic microwave ablation (BMWA) has considerably fewer pleural-based complications due to the avoidance of pleural puncture. BMWA can be considered in the multidisciplinary treatment pathway as it allows re-ablation and allows SBRT after BMWA. Summary With the benefits which ablative therapy offers and its ability to incorporate into the multidisciplinary management pathway, we foresee ablative therapy, especially BMWA gaining significance in lung cancer treatment. Future directions on developing novel automated navigation platforms and the latest form of ablative energy would further enhance clinical outcomes for our patients.

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Development of A 3D Lung Tumor Model For Cell Death Assessment in Microwave Ablation

Gallagher,

Mitra,

Ward

et al. 2024

Adv Funct Materials

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Primary lung cancer is the leading cause of cancer‐related death worldwide. Recent statistics estimate 1.8 million new cases and 1.6 million deaths per year. Despite significant advances in surgery, chemotherapy, and radiotherapy, the 5‐year survival rate remains at just 18%. Thermal ablation is an established treatment that is safe and effective. It refers to the local application of controlled heat to induce irreversible cell injury and ultimately tumor apoptosis and necrosis. This approach is particularly suitable for the treatment of small tumors in patients who are not suitable for surgery. However, the lack of suitable benchtop models to assess ablation devices complicates prognostic prediction and the development of effective treatment strategies. In this context, the development of a 3D lung tumor model is presented using a cancer cell‐laden hydrogel composed of 2% hyaluronic acid–tyramine (HA‐TA) and 0.5% agarose, resulting in a tumor mimetic of clinically relevant size. This innovative model provides a valuable platform for testing ablation devices and provides insights that can significantly improve prognostic ability and refine treatment approaches for lung cancer patients.

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Transbronchial Techniques for Lung Cancer Treatment: Where Are We Now?

Cited by 10 publications

References 59 publications

Ablation for Single Pulmonary Nodules, Primary or Metastatic. Εndobronchial Ablation Systems or Percutaneous

Ablation for Single Pulmonary Nodules, Primary or Metastatic. Εndobronchial Ablation Systems or Percutaneous

Treatment strategies for malignant pulmonary nodule: beyond lobectomy. Point-counterpoint

Development of A 3D Lung Tumor Model For Cell Death Assessment in Microwave Ablation

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