Transbronchial needle aspiration of hilar and mediastinal lymph nodes

Lannes, Deborah Cordeiro; Monteiro, Andreia Salarini; Toscano, Edson; Cavalcanti, Aureliano; Nascimento, Marilene; Biasi, Paulo de; Zamboni, Mauro

doi:10.1016/s2173-5115(07)70360-3

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Also Cetinkaya et al [36] found that diagnosis was made by TBNA in 65% of tuberculosis patients and 100% of patients with carcinoma. Again, the present study agreed with Lannes et al [25] who stated that sarcoidosis can only be definitively diagnosed through the detection of non caseous granuloma and TBNA with a fine needle plays a limited role in the diagnosis of the disease. Using TBNA concomitantly with transbronchial biopsy or even bronchial biopsy improves diagnostic efficiency.…”

Section: Discussionsupporting

confidence: 92%

“…Also Lannes et al [25] observed enlargement of main carina in 59%, enlargement of secondary carina in 16%, right or left paratracheal bulging in 7%, bulging on the posterior trachea wall in 4%, bulging of the right or left main bronchus in 7% and 7% of cases showed no abnormalities. Also Matsuoka et al [26] stated that endobronchial nodules were found in 0-33% of sarcoidosis patients.…”

Section: Discussionmentioning

confidence: 92%

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Anatomical and histopathological airway abnormalities detected during fiberoptic bronchoscopy in patients with mediastinal lymphadenopathy

Eid

Khatab

Ahmed

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: The diagnosis in cases of mediastinal and hilar lymphadenitis without parenchymal involvement of the lung is often difficult. Mediastinal lymphadenopathy may be due to a variety of benign or malignant reasons. Hence, it is important to establish a diagnosis and differentiate benign from malignant lymph nodes.Aim of the work: To study the usefulness of fiberoptic bronchoscopy in diagnosis of patients with mediastinal lymphadenopathy.Patients and methods: The present study included 30 patients with mediastinal lymphadenopathy. All were subjected to written informed consent, full history taking, full clinical examination, tuberculin skin test, chest X-ray and CT chest. Fiberoptic bronchoscopy including autofluorescence bronchoscopy with mucosal biopsies, TBNA and bronchial lavage were also obtained.Results: 46.7% of the study patients were diagnosed as malignancy, 20% diagnosed as sarcoidosis, 10% diagnosed as TB, 3.33% diagnosed as reactive lymphadenitis and 20% were undiagnosed. Observed anatomical airway abnormalities included vocal cord paralysis (16.7%), tracheal compression (3.3%), widening of main or second carina (80%) and mucosal abnormalities (46.7%) in the form of nodules, infiltration with tumour tissue and unhealthy mucosa. Bronchial mucosal biopsy was the most useful method of diagnosis (56.7%) followed by TBNA (30%) and finally BAL (13.3%). AFB has no cost effective value over WLB in detection of malignant lesions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Anatomical and histopathological airway abnormalities detected during fiberoptic bronchoscopy in patients with mediastinal lymphadenopathy

Eid

Khatab

Ahmed

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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“… 32 , 33 In 2007, experts at INCA reported their experience with bronchoscopy-guided transbronchial needle aspiration, which is considered a safe and effective procedure. 34 Samples were deemed satisfactory in 57% of the cases, 81% of those allowing a definitive diagnosis. 34 Some groups have also developed expertise in CT-guided transthoracic fine-needle aspiration, showing high diagnostic yield, accuracy, and safety.…”

Section: Diagnostic Proceduresmentioning

confidence: 97%

“… 34 Samples were deemed satisfactory in 57% of the cases, 81% of those allowing a definitive diagnosis. 34 Some groups have also developed expertise in CT-guided transthoracic fine-needle aspiration, showing high diagnostic yield, accuracy, and safety. 35 After 2010, endobronchial ultrasound was introduced in a few large institutions, and the initial experience with 50 cases has been reported.…”

Section: Diagnostic Proceduresmentioning

confidence: 97%

Lung cancer in Brazil

2018

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Lung cancer is one of the most incident types of cancer and a leading cause of cancer mortality in Brazil. We reviewed the current status of lung cancer by searching relevant data on prevention, diagnosis, and treatment in the country. This review highlights several issues that need to be addressed, including smoking control, patient lack of awareness, late diagnosis, and disparities in the access to cancer health care facilities in Brazil. We propose strategies to help overcome these limitations and challenge health care providers, as well as the society and governmental representatives, to work together and to take a step forward in fighting lung cancer.

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“…1). 37 The primary role of lymphatics is to regulate interstitial fluid volume in conjunction with constantly changing volume and pressure in the blood vasculature. 38,39…”

Section: Human Lung Structure Function and Cellular Compositionmentioning

confidence: 99%

Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung

Patel

Metcalf

2018

Crit Rev Immunol

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Dendritic cells (DCs) and macrophages (MΦs) are antigen-presenting phagocytic cells found in many peripheral tissues of the human body, including the blood, lymph nodes, skin, and lung. They are vital to maintaining steady-state respiration in the human lung based on their ability to clear airways while also directing tolerogenic or inflammatory responses based on specific stimuli. Over the past three decades, studies have determined that there are multiple subsets of these two general cell types that exist in the airways and interstitium. Identifying these numerous subsets has proven challenging, especially with the unique microenvironments present in the lung. Cells found in the vasculature are not the same subsets found in the skin or the lung, as demonstrated by surface marker expression. By transcriptional profiling, these subsets show similarities but also major differences. Primary human lung cells and/or tissues are difficult to acquire, particularly in a healthy condition. Additionally, surface marker screening and transcriptional profiling are continually identifying new DC and MΦ subsets. While the overall field is moving forward, we emphasize that more attention needs to focus on replicating the steady-state microenvironment of the lung to reveal the physiological functions of these subsets.

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Transbronchial needle aspiration of hilar and mediastinal lymph nodes

Abstract: Punção aspirativa transbrônquica por agulha de linfonodos hilares e mediastinais Transbronchial needle aspiration of hilar and mediastinal lymph nodes Recebido para publicação/received for publication: 06.07.04 Aceite para publicação/accepted for publication: 07.03.26

Cited by 6 publications

References 14 publications

Anatomical and histopathological airway abnormalities detected during fiberoptic bronchoscopy in patients with mediastinal lymphadenopathy

Anatomical and histopathological airway abnormalities detected during fiberoptic bronchoscopy in patients with mediastinal lymphadenopathy

Lung cancer in Brazil

Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung

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