Transbronchial Lung Cryobiopsy (TBLC) at a Tertiary Referral Hospital: A Two-Year Experience

Dalvi, Prachiti; Kretz, Gabriella; Clum, Stephen; Markow, M J; DiNuoscio, David; Rumbak, Mark J.; Mangar, Devanand; Camporesi, Enrico

doi:10.15761/pccm.1000122

Cited by 4 publications

(3 citation statements)

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“…Four of these studies only provided safety-related data, therefore they were only used while analyzing safety profile. 36,51,53,54 Only 1 non-English study was included. It was published by Fournier and colleagues in French.…”

Section: Search and Study Selectionmentioning

confidence: 99%

Are Transbronchial Cryobiopsies Ready for Prime Time?

Sethi

Ali

Mohananey

et al. 2019

Journal of Bronchology &Amp; Interventional Pulmonology

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Section: Search and Study Selectionmentioning

confidence: 99%

Are Transbronchial Cryobiopsies Ready for Prime Time?

Sethi

Ali

Mohananey

et al. 2019

Journal of Bronchology &Amp; Interventional Pulmonology

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“…After reviewing 1003 studies, 68 studies (44 full texts2,14–56 and 24 abstracts57–80) met our inclusion criteria and were included in the final analysis with a total of 6386 patients. The mean age of the group was 60.7±14.1 years and 56% were males.…”

Section: Resultsmentioning

confidence: 99%

Role of Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease

Zayed

Alzghoul

Hyde

et al. 2022

Journal of Bronchology &Amp; Interventional Pulmonology

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Background: Diagnosis of interstitial lung disease (ILD) is based on multidisciplinary team discussion (MDD) with the incorporation of clinical, radiographical, and histopathologic information if available. We aim to evaluate the diagnostic yield and safety outcomes of transbronchial lung cryobiopsy (TBLC) in the diagnosis of ILD.Methods: We conducted a meta-analysis by comprehensive literature search to include all studies that evaluated the diagnostic yields and/or adverse events with TBLC in patients with ILD. We calculated the pooled event rates and their 95% confidence intervals (CIs) for the diagnostic yield by MDD, histopathologic diagnostic yield, and various clinical adverse events.Results: We included 68 articles (44 full texts and 24 abstracts) totaling 6386 patients with a mean age of 60.7 ± 14.1 years and 56% men. The overall diagnostic yield of TBLC to achieve a definite or high-confidence diagnosis based on MDD was 82.3% (95% CI: 78.9%-85.2%) and histopathologic diagnosis of 72.5% (95% CI: 67.7%-76.9%). The overall rate of pneumothorax was 9.6% (95% CI: 7.9%-11%), while the rate of pneumothorax requiring drainage by a thoracostomy tube was 5.3% (95% CI: 4.1%-6.9%). The rate of moderate bleeding was 11.7% (95% CI: 9.1%-14.9%), while the rate of severe bleeding was 1.9% (95% CI: 1.4%-2.6%). The risk of mortality attributed to the procedure was 0.9% (95% CI: 0.7%-1.3%).Conclusion: Among patients with undiagnosed or unclassified ILD requiring tissue biopsy for diagnosis, transbronchial cryobiopsy represents a reliable alternative to surgical lung biopsy with decreased incidence of various clinical adverse events.

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“…Fluoroscopy is used to assess for evidence of pneumothorax. Data collected from over 300 cryobiopsies performed at these hospitals had a 5.4% incidence of pneumothorax and no significant bleeding .…”

Section: Discussionmentioning

confidence: 99%

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by tranbronchoscopic cryoprobe biopsy technique

Patel

Collazo-Gonzalez

Andrews

et al. 2017

Respirology Case Reports

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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) remains a poorly understood clinical entity. It is currently classified as a premalignant condition by the World Health Organization (WHO). Symptoms are similar to those associated with obstructive lung disease, including breathlessness and cough. The presentation is often initially ascribed to other diseases such as asthma or chronic obstructive pulmonary disease. Here, we present what we believe is the first described case of DIPNECH diagnosed by transbronchoscopic cryoprobe biopsy. The patient presented with chronic cough, dyspnoea, pulmonary function tests consistent with obstruction, and a computed tomography (CT) scan of chest with multiple nodules. The patient went on to have transbronchoscopic cryoprobe biopsies of the lung, which confirmed the diagnosis of DIPNECH.

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Transbronchial Lung Cryobiopsy (TBLC) at a Tertiary Referral Hospital: A Two-Year Experience

Cited by 4 publications

References 0 publications

Are Transbronchial Cryobiopsies Ready for Prime Time?

Are Transbronchial Cryobiopsies Ready for Prime Time?

Role of Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by tranbronchoscopic cryoprobe biopsy technique

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