2019
DOI: 10.2139/ssrn.3420429
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Transbronchial Lung Cryobiopsy for Interstitial Lung Disease Diagnosis: Results of the COLDICE Study

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“…In addition, the authors acknowledge that some patients had a diagnosis based on cryobiopsy or TBLB, which is currently not recommended by IPF guidelines. However, cryobiopsy has been shown to be useful for the diagnosis of ILD on the recent COLDICE study [ 22 ] and it is unclear whether a TBLB-based molecular classifier would overrule results of cryobiopsy and have less potential adverse effects.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the authors acknowledge that some patients had a diagnosis based on cryobiopsy or TBLB, which is currently not recommended by IPF guidelines. However, cryobiopsy has been shown to be useful for the diagnosis of ILD on the recent COLDICE study [ 22 ] and it is unclear whether a TBLB-based molecular classifier would overrule results of cryobiopsy and have less potential adverse effects.…”
Section: Discussionmentioning
confidence: 99%
“…Yet, due to the negative primary end-point, effects have to be interpreted with caution. The multicentric COLDICE study assessed the agreement between transbronchial lung cryobiopsy (TBLC) and surgical lung biopsy and found a high level of agreement (weighted κ 0.70, 95% CI 0.55-0.86) [28]. The use of TBLC for ILD diagnosis is thus supported.…”
Section: Ilds/dplds Of Known Originmentioning
confidence: 98%