Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease

Ussavarungsi, Kamonpun; Kern, Ryan; Roden, Anja C.; Ryu, Jay H.; Edell, Eric S.

doi:10.1016/j.chest.2016.09.002

Cited by 117 publications

(113 citation statements)

References 30 publications

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“…Thus a surgical lung biopsy could be avoided in 80% of the patients who benefit from cryobiopsies. This result is in agreement with previously published data and recent meta-analyses showing a global diagnostic yield of cryobiopsies of around 80% [6, 12–14, 19–22]. The most frequent diagnoses obtained were IPF and HP.…”

Section: Discussionsupporting

confidence: 93%

Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

Bondue

Pieters

Alexander³

et al. 2017

Pulmonary Medicine

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Background. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs). However, no comparison with surgical lung biopsy (SLB) in the same patient is available. Methods. The diagnostic yield and safety data of TBLCs, as well as the result of SLB performed after TBLCs, were analysed in a multicentric Belgian study. A SLB was performed after TBLCs in absence of a definite pathological diagnosis or if a NSIP pattern was observed without related condition identified following multidisciplinary discussion. Results. Between April 2015 and November 2016, 30 patients were included. Frequent complications included pneumothorax (20%) and bleeding (severe 7%, moderate 33%, and mild 53%). There was no mortality. The overall diagnostic yield was 80%. A SLB was performed in six patients (three without definite histological pattern and three with an NSIP). The surgical biopsy changed the pathological diagnosis into a UIP pattern in five patients and confirmed a NSIP pattern in one patient. Conclusion. TBLCs are useful in the diagnostic work-up of DPLDs avoiding a SLB in 80% of the patients. However, surgical biopsies, performed as a second step after TBLCs because of an indefinite diagnosis or a NSIP pattern, provide additional information supporting the interest of a sequential approach in these patients.

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Section: Discussionsupporting

confidence: 93%

Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

Bondue

Pieters

Alexander³

et al. 2017

Pulmonary Medicine

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“…Flexible cryoprobes were first used to diagnose and manage central airway lesions . In recent years, transbronchial cryobiopsy had been applied to the diagnosis of parenchymal lung disease .…”

Section: Discussionmentioning

confidence: 99%

Novel application of cryobiopsy in the diagnosis of pulmonary alveolar proteinosis

Shen

Lee

et al. 2018

Respirology Case Reports

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Pulmonary alveolar proteinosis (PAP) is a rare disease diagnosed pathologically by the build up of surfactant in the alveolar spaces. Establishing a diagnosis usually requires invasive procedures such as bronchoalveolar lavage and forceps biopsy to obtain tissue specimens. Infrequently, surgery is required when histopathological results from other modalities are equivocal. Cryobiopsy has emerged as a novel technique for obtaining lung tissues in pulmonary diseases. Recently, cryobiopsy has been used to diagnose diffuse parenchymal lung disease, but it has rarely been used for the diagnosis of PAP. Here, we describe a 54‐year‐old male businessman presenting with intermittent coughing with yellowish sputum and dyspnoea upon exertion for half a year. Tissues from forceps biopsy fail to yield a specific diagnosis, whereas those from cryobiopsy confirm the diagnosis of PAP. Cryobiopsy offers several diagnostic advantages compared to conventional techniques and appears to be a potential diagnostic tool for diagnosing PAP.

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“…We describe a case of primary lung adenocarcinoma presenting as subacute pneumonia and progressing to the development of respiratory distress. Given our suspicion of interstitial lung disease, with our top two diagnoses being acute interstitial pneumonitis (AIP) and cryptogenic organizing pneumonia (COP), we chose to obtain transbronchial cryobiopsies that provide larger tissue samples and have a higher diagnostic yield compared to conventional forceps biopsies . The diagnostic yield of transbronchial cryobiopsy is widely variable depending on the technique used and has been reported to be 51–80% .…”

Section: Discussionmentioning

confidence: 99%

“…Given our suspicion of interstitial lung disease, with our top two diagnoses being acute interstitial pneumonitis (AIP) and cryptogenic organizing pneumonia (COP), we chose to obtain transbronchial cryobiopsies that provide larger tissue samples and have a higher diagnostic yield compared to conventional forceps biopsies [1][2][3][4][5][6][7]. The diagnostic yield of transbronchial cryobiopsy is widely variable depending on the technique used and has been reported to be 51-80% [2,3,6,8]. The overall diagnostic yield at our institution using a two-scope technique is 84-89% (Cooley J, Sriprasart T, Benzaquen S, unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Pneumonic‐type mucinous lung adenocarcinoma diagnosed by transbronchial cryobiopsy

Balestra

Selvaraju

Benzaquen

et al. 2017

Respirology Case Reports

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Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease

Cited by 117 publications

References 30 publications

Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

Novel application of cryobiopsy in the diagnosis of pulmonary alveolar proteinosis

Pneumonic‐type mucinous lung adenocarcinoma diagnosed by transbronchial cryobiopsy

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