Transarterial Treatment of Lung Cancer

Abstract

Purpose: The treatment efficacy of the transarterial approach to lung cancer is evaluated. Materials and Methods: A total of 98 patients with advanced lung cancer or recurrent lung cancer after the standard therapies were enrolled retrospectively. The bronchial arteries and mediastinal branches from the subclavian artery were selected by a microcatheter. Immediately after the selective arterial infusion of anti-neoplastic agents, embolization with a spherical embolic material was carried out. Local tumor effects and overall survival were evaluated. Result: The mean reduction rate was 17.9%, with 24.2% for partial remission and with 2.1% for progression disease. The rate of stable disease was 72.6%. The response rate was 25.3%, and the disease control rate was 97.9%. The median survival time (MST) was 11.4 months, the 1-year survival rate was 45.2%, and the 2-year survival rate was 35.6%. Although it is insignificant, the MST for 51 adenocarcinomas was higher than that of 29 squamous cell carcinomas (18.6 months and 9.4 months, respectively). The local extension of tumors related to a better prognosis, though it was not significant. Lymph node metastases and distant metastases were poor prognostic factors. No major complications nor treatment-related mortalities were found in this study. Conclusion: The transarterial treatment for lung cancer should be considered as a treatment option when the other treatments were not indicated both in initial cases and in recurrent cases.

Progress in the Prevention of Complications of Interventional Therapy in Patients with Lung Cancer Hemoptysis

“…It has (Papaporfyriou A, Domayer J, Meilinger M, et al, 2021;Ozdemir C, Sokucu SN, Berk A, et al, 2019) been reported that bronchoscopic interventional therapy for endovascular tumor elimination can achieve a higher long-term survival of patients. Hori et al (2022) have also suggested that trans arterial intervention for lung cancer should be considered as a viable treatment option. Bronchoscopic interventional Therapy, especially Photodynamic Therapy (PDT), can achieve radical curative effect on early invasive cancer and low grade malignancy, and may become a treatment method (Ikeda N, Usuda J & Maehara S, 2020) that can replace surgery.…”