Transarterial Embolization for Large Hepatocellular Carcinoma with Use of Superabsorbent Polymer Microspheres: Initial Experience

Osuga, Keigo; Khankan, Azzam; Hori, Shingo; Okada, Atsuya; Sugiura, Toshihiro; Maeda, Munehiro; Nagano, Hiroaki; Yamada, Akira; Murakami, Takamichi; Nakamura, Hajime

doi:10.1016/s1051-0443(07)61777-1

Cited by 53 publications

(29 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several single arm studies have reported partial or complete tumor response after transarterial embolization with particles only and no drug solution [6,31,32]. In the present study, it cannot be evidenced whether the necrotic effect of DEB-DOX is due to the delivery of doxorubicin or to the embolic effect of the particle, as no patient received bland embolization.…”

Section: Discussioncontrasting

confidence: 65%

Embolization of hepatocellular carcinoma with drug-eluting beads: Doxorubicin tissue concentration and distribution in patient liver explants

Namur

Citron

Sellers

et al. 2011

Journal of Hepatology

151

136

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 65%

Embolization of hepatocellular carcinoma with drug-eluting beads: Doxorubicin tissue concentration and distribution in patient liver explants

Namur

Citron

Sellers

et al. 2011

Journal of Hepatology

151

136

View full text Add to dashboard Cite

“…Recently, drug-eluting beads were developed [10,11] which provide a potentially higher local effect of the antimitotic drug and less systemic side effects. To date, there are 2 different types of drug-eluting beads: polyvinyl alcoholbased (PVA) microspheres (DC Bead ® , BioCompatibles Ltd., Farnham, UK) and superabsorbent polymer (SAP) microspheres (HepaSphere ® (Europe) / QuadraSphere ® (USA), Biosphere Medical, Rockland, MA, USA)).…”

Section: Introductionmentioning

confidence: 99%

A Randomized Phase II Study of Drug-Eluting Beads versus Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma

Malenstein¹,

et al. 2011

View full text Add to dashboard Cite

Background: Transcatheter arterial chemoembolization (TACE) is the standard treatment in selected patients with unresectable hepatocellular carcinoma (HCC). Drug-eluting particles are developed to reduce side effects and improve efficacy. We present safety data of a prospective randomized phase II study with doxorubicin-eluting superabsorbent polymer (SAP) microspheres. Material and Methods: We prospectively included 30 HCC patients with different Barcelona Clinic Liver Cancer (BCLC) stages (A = 3, B = 19, C = 8) and randomly assigned them to receive conventional TACE (n = 14) (control group) or doxorubicin-eluting SAP microspheres (n = 16). The doxorubicin plasma level was assessed at different time points, biochemical analysis was performed, and side effects were reported following the Common Toxicity Criteria. Tumor response was assessed at 6 weeks according to the modified Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Results: There was a significantly lower plasma peak concentration (Cmax) of doxorubicin and smaller area under the curve (AUC) with SAP microspheres (mean Cmax 495 ± 293.9 ng/ml, mean AUC 69.7 ± 26.9 ng/ml min) compared to controls (mean Cmax 1,928 ± 560.8 ng/ml, mean AUC 165 ± 32.3 ng/ml/min; both p < 0.001). Furthermore, there were less grade 3 and no grade 4 adverse events in the SAP microsphere group. Tumor response was comparable between the groups. Conclusions: TACE with SAP microspheres leads to low plasma levels of the cytotoxic drug and therefore minimizes toxicity compared to conventional TACE.

show abstract

“…The long-term materials include gelatin sponges and microspheres [57]. Permanent embolisation materials include metallic coil, NBCA, and PVA, which are not degradable [58]. Another embolisation technique combined with radioactive materials is called vascular brachytherapy, which can be used for the treatment of stent restenosis [59,60].…”

Section: Bioactive Materials Used For Embolisation and Brachytherapymentioning

confidence: 99%

Bioactive materials in the circulatory system

Zhao¹,

Courtney²

2011

Bioactive Materials in Medicine

View full text Add to dashboard Cite

Transarterial Embolization for Large Hepatocellular Carcinoma with Use of Superabsorbent Polymer Microspheres: Initial Experience

Cited by 53 publications

References 13 publications

Embolization of hepatocellular carcinoma with drug-eluting beads: Doxorubicin tissue concentration and distribution in patient liver explants

Embolization of hepatocellular carcinoma with drug-eluting beads: Doxorubicin tissue concentration and distribution in patient liver explants

A Randomized Phase II Study of Drug-Eluting Beads versus Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma

Bioactive materials in the circulatory system

Contact Info

Product

Resources

About