Transapical mitral valved stent implantation: Enhanced survival and decreased paravalvular leakages

Pokorny, Saskia; Huenges, Katharina; Bähr, Telse; Hansen, Jan Hinnerk; Fischer, G.; Groß, Justus; Morlock, Michael M.; Cremer, Jochen; Lutter, Georg

doi:10.1016/j.ijcard.2014.06.007

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…Particular challenges for the development of such a device are the complex anatomy of the native mitral valve apparatus, the relative motion of the native mitral annulus and its position in the high-pressure system of the left heart. Previously, different studies have been published focusing on echocardiographic evaluation after mitral valved stent implantation in the beating heart 4,5,13,14 . In this study, the mechanical in vivo deformations of mitral valved stents have been quantified by computed tomographic analysis for the first time.…”

Section: Discussionmentioning

confidence: 99%

“…An LVOT obstruction was detected in two of eleven cases (45°: n=1; 90°: n=1) (Table 1). No paravalvular leakages (PVL) were detected in the 110°-angled group after successful stent implantation 13 . In the other two groups, mild and trace PVL was detected in both groups 14 .…”

Section: Stent Positionmentioning

confidence: 95%

“…Twelve pigs (German Landrace and German Edelschwein) with an average body weight of 49.9±3.8 kg underwent transapical mitral valved stent implantation in an off-pump technique, as described previously 4,5 . A lower ministernotomy was performed, granting access to the apex of the heart in the porcine model 4,5,13,14 . Stent deployment and positioning was performed under transoesophageal echocardiographic (TEE) guidance (Philips iE33 xMatrix, TEE Probe X7-2t; Philips Healthcare, Best, The Netherlands).…”

Section: Transapical Implantation Proceduresmentioning

confidence: 99%

“…Research Council and published by the National Academy Press, revised in 2011. Echocardiographic and haemodynamic data of pigs implanted with a mitral valved stent prototype have been published previously 4,5,13,14 .…”

Section: Figure 1 Schematic Drawing and Image Of 45° Angle Prototype (A And B); 90° Angle Prototype (C And D); And 110° Angle Prototype (mentioning

confidence: 99%

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Transapical mitral valved stent implantation: computed tomographic evaluation of different prototype designs

Pokorny

Heinig²,

Hettich³

et al. 2015

EuroIntervention

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The effectiveness of cardiac computed tomography in the development process of valved stents to provide essential information and quantitative data about the in vivo stent geometry was demonstrated. The in vivo mechanical deformations of the stent were quantified, identifying critical design areas: a larger preset angle leads to less deflection and improved alignment and hence reduces the mechanical load.

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Section: Discussionmentioning

confidence: 99%

Section: Stent Positionmentioning

confidence: 95%

Section: Transapical Implantation Proceduresmentioning

confidence: 99%

Section: Figure 1 Schematic Drawing and Image Of 45° Angle Prototype (A And B); 90° Angle Prototype (C And D); And 110° Angle Prototype (mentioning

confidence: 99%

See 2 more Smart Citations

Transapical mitral valved stent implantation: computed tomographic evaluation of different prototype designs

Pokorny

Heinig²,

Hettich³

et al. 2015

EuroIntervention

Self Cite

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“…Although new apical closure devices have been developed and tested in animals and humans, the apical closure remains a challenge in recent studies [2]. The cardiologists started to use the occluders to closure the percutaneous apical accesses [3][4][5][6][7][8][9][10][11]. We report a case of a successful percutaneous closure of the apical access with a 4 mm ADO-II device after a standard transapical mitral paravalvular leak closure procedure without minithoracotomy.…”

Section: Dear Editormentioning

confidence: 99%

Percutaneous transapical closure of cardiac apex with an ADO-II device after successful transapical transcatheter prosthetic mitral paravalvular leak closure

İyisoy

Öztürk

Çelik

et al. 2015

International Journal of Cardiology

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Interventioneller Ersatz der Mitralklappe

Lutter

Frank

2015

Herz

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Approximately 30 % of patients suffering from severe valvular heart disease, such as mitral valve regurgitation are non-compliant to the gold standard of minimally invasive surgery, reconstruction or valve replacement. The number of these mostly old patients with severe comorbidities is increasing; therefore, transcatheter interventions have been developed to address an unmet clinical need and may be an alternative therapeutic option to the reference standard. Apart from the successful MitraClip therapy, alternative transcatheter reconstruction technologies are being developed. As with transcatheter aortic valve implantation (TAVI) procedures, the off-pump implantation of a valved stent into the mitral position mainly via a transapical approach will be of great benefit. Recently, the feasibility of transcatheter mitral valved stent implantation in high-risk patients has already been reported.

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Transapical mitral valved stent implantation: Enhanced survival and decreased paravalvular leakages

Cited by 8 publications

References 14 publications

Transapical mitral valved stent implantation: computed tomographic evaluation of different prototype designs

Transapical mitral valved stent implantation: computed tomographic evaluation of different prototype designs

Percutaneous transapical closure of cardiac apex with an ADO-II device after successful transapical transcatheter prosthetic mitral paravalvular leak closure

Interventioneller Ersatz der Mitralklappe

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