Abstract:A transannular approach has been developed for the construction
of pyrrolo[1,2-
b
]isoquinolinones starting from benzo-fused
nine-membered enelactams. This process takes place in the presence
of a halogenating agent and under Brønsted acid catalysis and
proceeds via a transannular amidohalogenation, followed by elimination.
The reaction has been found to be wide in scope, enabling the formation
of a variety of tricyclic products in good overall yield, regardless
of the substitution patte… Show more
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