Transaminase Studies Following Anesthesia

Wl, Collins; Lw, Fabian

doi:10.1097/00007611-196405000-00013

Cited by 6 publications

(3 citation statements)

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“…Studies in animals indicate that this interval should be approximately 4 weeks (Bruce, 1972). In people, the degree of liver dysfunction induced by halothane as evidenced by increased AsA and AlA activity is comparable with that induced by ether and cyclopropane (Little, Barbour & Given, 1958;Collins & Fabian, 1964). Similar results have been reported in animals (Wolff, Lumb & Kamsey, 1967;Stephen, Margolis, Fabian & Bourgeois-Gavardin, 1958;Benson, Hartsfield, Manning, 'I'hurmon, 1980).…”

Section: H a L O T H A N E -A S S O C I A T E D H E P A T I T I Smentioning

confidence: 58%

Halothane‐associated hepatitis and methoxyflurane‐related nephropathy: a review

Brock

1980

Vet Pharm & Therapeutics

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Section: H a L O T H A N E -A S S O C I A T E D H E P A T I T I Smentioning

confidence: 58%

Halothane‐associated hepatitis and methoxyflurane‐related nephropathy: a review

Brock

1980

Vet Pharm & Therapeutics

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“…For instance, serum transaminase levels have been recorded for as long as two weeks following administration of halothane. 1 It is worth while to note that ff it is true that a drug induces changes which are either not reversible or only slowly reversible, then, by the stochastic theory of mortality,2, 8 some interesting predictions become possible. In effect it can be forecast that if, following cessation of administration of the drug, functional changes have been induced such that a deviation from a "mean physiologic state '~-has occurred, then the value for the force of mortality should also change for as long as the after-effects of the drug are present.…”

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confidence: 99%

Effects of halothane on life expectancy of mice

Boba

Drews

1966

Can. Anaes. Soc. J.

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THE F.FFECrS of halothane in animals and humans have been studied in a variety of ways. Practically all investigations have been directed toward quantitation of the acute effects of the drug.Becently, because of the alleged hepatotoxie properties of halothane, some attempts have been made to investigate the possibility that this drug might produce changes which are either not reversible or very slowly reversible after withdrawal of the drug. For instance, serum transaminase levels have been recorded for as long as two weeks following administration of halothane. 1It is worth while to note that ff it is true that a drug induces changes which are either not reversible or only slowly reversible, then, by the stochastic theory of mortality,2, 8 some interesting predictions become possible. In effect it can be forecast that if, following cessation of administration of the drug, functional changes have been induced such that a deviation from a "mean physiologic state '~-has occurred, then the value for the force of mortality should also change for as long as the after-effects of the drug are present.It should be obvious that at the present state of knowledge it is not possible to predict a positive or negative effect on mortality rate. Also, in this context, it is probably irrelevant whether the alleged after-effects of the drug are the results of protoplasmic or molecular changes or the by-product of the retention within the cell of traces of the drug not demonstrable by conventional assay methods.This study was undertaken because the question of halothane toxicity had not been previously approached in this context, and because the development of a methodology capable of demonstrating these phenomena was thought to be needed. MATaa~L~ ANn MI~THODSA batch of 500 white mice, half of them males and half of them females, and all of them born within a 94-hour period, were purchased from a biological supply house. The sexes were separated before puberty and no admixture of the sexes was allowed at any time thereafter.At the age of ten weeks they were housed in small cages each containing eight animals. When they were twelve weeks old, four groups of 96 mice each were created by selecting for each group six cages of females and six cages of males. At this time each cage was humbered, and the animals within each cage were identified by means of ear punches. A file for each animal in the form of a coded punch card was initiated. The extra animals were destroyed at this time.

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“…The degree of postoperative liver dysfunction appears to be uninfluenced by the type of anaesthesia used (Little and Given, 1964;Joseph, 1964). Retrospective studies of the incidence of postoperative liver failure have shown it to be relatively unaltered irrespective of the changes which have occurred in anaesthetic methods (Dawson et al, 1963;Mazzia, 1963;Keeri-Szant6 and Lafleur, 1963;Wilson, Tarrow and Garvin, 1964;Allen and Metcalf, 1964;Slater et al, 1964;Mushin et al, 1964;Reichmann and Wohlgemuth, 1964;Collins and Fabian, 1964;Henderson and Gordon, 1964).…”

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confidence: 99%

Liver Injury in the Surgical Patient: A Critical Review

Johnstone¹

1964

British Journal of Anaesthesia

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This is a critical review of the reports of postoperative jaundice and liver necrosis that have been published during the past twenty-five years. Postoperative liver damage has the following causes: transmitted, provoked, or coincidental viral infections; acute sepsis and septicaemic states; blood transfusion; widespread vasoconstriction with hypotension lasting more than twenty-four hours; allergic reactions to antigenic substances; alleged "hypersensitivity" to drugs to which antibodies cannot be identified; the direct effects of certain therapeutic agents on the liver; surgical trauma to the liver and its appendages; and postoperative pancreatitis. Several of these factors may operate simultaneously in the patient recovering from a surgical operation and in these circumstances it is impossible to dissociate one particular cause from the others. The syndromes of viral hepatitis and drug "hypersensitivity" are indistinguishable. Both are associated with fever, skin rashes, leucopenia, arthralgia, cholestatic jaundice, and liver necrosis with a mononuclear infiltration of the liver. Both are peculiar to man and the time interval between the exposure to risk and the appearance of jaundice varies from less than seven days to more than three months. The development of immunity to the one or desensitization from the other is not universal. There is no inhalational anaesthetic agent in common use which comes within the definitions of directly or indirectly hepatotoxic substances. The pharmacological methods of screening inhalational anaesthetic agents for hepatotoxidty have always been reliable and there is no reason to doubt their efficacy at the present time.

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Transaminase Studies Following Anesthesia

Cited by 6 publications

References 0 publications

Halothane‐associated hepatitis and methoxyflurane‐related nephropathy: a review

Halothane‐associated hepatitis and methoxyflurane‐related nephropathy: a review

Effects of halothane on life expectancy of mice

Liver Injury in the Surgical Patient: A Critical Review

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