Transactions of the Philadelphia Academy of Surgery

Müller, George P.; Smyth, Calvin M.

doi:10.1097/00000658-193105000-00017

Cited by 2 publications

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“…[7] Many drugs in use today contain this moiety, and several nitroimidazole derivatives such as metronidazole (MTZ), tinidazole, ornidazole, secnidazole, and ronidazole have been used for the treatment of serious infections caused by anaerobic bacteria and protozoa. [7] Many drugs in use today contain this moiety, and several nitroimidazole derivatives such as metronidazole (MTZ), tinidazole, ornidazole, secnidazole, and ronidazole have been used for the treatment of serious infections caused by anaerobic bacteria and protozoa.…”

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“…EhTrR is therefore an excellent target for the chemotherapy of protozoal infections, amoebiasis in particular.The 5-nitroimidazoles are a well-established group of antiprotozoal and antibacterial agents. [7] Many drugs in use today contain this moiety, and several nitroimidazole derivatives such as metronidazole (MTZ), tinidazole, ornidazole, secnidazole, and ronidazole have been used for the treatment of serious infections caused by anaerobic bacteria and protozoa. [8] Although treatment with MTZ is very effective, it has been found that anaerobic bacteria and protozoa develop resistance to MTZ by reducing or abolishing the activity of elements of the series of electron transport reactions.…”

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In Vitro Antiamoebic Activity Evaluation and Docking Studies of Metronidazole–Triazole Hybrids

et al. 2014

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An in-house database of 520 compounds was docked against Entamoeba histolytica thioredoxin reductase (EhTrR), a promising target for the treatment of amoebiasis. Amongst these, some metronidazole (MTZ)-triazole hybrids were ranked high, with docking scores from -10.23 to -7.56. Studies of the binding orientations and conformations show that the head groups of MTZ-triazole hybrids interact with the arginine residues within the binding pocket of EhTrR, making it clear that such is the optimal and most reliable orientation for this class of compounds. The top-ten MTZ-triazole hybrids were then selected for evaluation of their activity against the HM1:IMSS strain of amoeba. The most active compound, 2-pyridyl-(1,2,3-triazolyl)metronidazole 10, with an IC50 value of 8.4 nM, was significantly more active than the standard drug MTZ alone. Docking studies revealed that compound 10 may act as an EhTrR inhibitor with activity in the nanomolar range and satisfactory ADME properties; it is a suitable candidate to be carried forward as a potential lead in the discovery of drugs to combat amoebiasis.

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In Vitro Antiamoebic Activity Evaluation and Docking Studies of Metronidazole–Triazole Hybrids

et al. 2014

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“…One of the earliest reports of tibial sesamoidectomy with relief of symptoms was described by Müller in 1911. 1 Recently, Jones et al, reported the results of tibial sesamoid excision following tibial sesamoid fracture in a softball player. After 1 year, the patient was "free of pain in all shoe types".…”

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ntaneous Fracture of the Tibial Sesamoid: A case report

Kline¹

2008

FAOJ

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Tibial sesamoid fracture is common in athletes and active individuals. Usually, the incident is preceded by stress injury or acute trauma from stressed dorsiflexion or hyperextension of the hallux. The first ray will transmit about 60% of a person's weight-bearing stress through the first metatarsophalangeal joint during the gait cycle. In acute instances, these stresses can be many times greater. Interestingly, there have been infrequent reports of tibial sesamoid fracture from non-acute injury such as walking. In non-acute injuries, many patients will present with a sharp initial pain followed by a dull ache or pain under the sesamoids. The differential diagnosis may include sesamoiditis, chondromalacia, first metatarsal joint capsulitis, flexor hallucis tendonitis and arthritis.

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Transactions of the Philadelphia Academy of Surgery

Cited by 2 publications

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In Vitro Antiamoebic Activity Evaluation and Docking Studies of Metronidazole–Triazole Hybrids

In Vitro Antiamoebic Activity Evaluation and Docking Studies of Metronidazole–Triazole Hybrids

ntaneous Fracture of the Tibial Sesamoid: A case report

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