Transabdominal Measurement of Oxygenation of the Placenta by Near-Infrared Spectroscopy

Kakogawa, Jun; Sumimoto, Kazuhiro; Ho, Ei; Kanayama, Naohiro

doi:10.1055/s-2005-872435

Cited by 17 publications

(18 citation statements)

References 1 publication

(1 reference statement)

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“…In this regard, noninvasive approaches, such as near-infrared spectroscopy and blood oxygen level-dependent magnetic resonance imaging may prove to be safe and reliable methodologies (15,16). When relative placental ischemia-hypoxia is a component of the disease, then strategies to improve uteroplacental blood flow may be beneficial, to improve placental and fetal growth, and/or alleviate maternal endothelial dysfunction by reducing circulating toxic factors that emanate from the placenta as a consequence of local hypoxia.…”

Section: Discussionmentioning

confidence: 98%

Placental HIF-1α, HIF-2α, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction

Rajakumar

Jeyabalan

Marković

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Inadequate trophoblast invasion and spiral artery remodeling leading to poor placental perfusion are believed to underlie the pregnancy pathologies preeclampsia (PE) and intrauterine growth restriction (IUGR). The main objective of this study was to investigate hypoxia-inducible transcription factor-alpha (HIF-alpha) and downstream genes (VEGF receptor-1) Flt-1 and soluble fms-like tyrosine kinase 1 (sFlt-1) proteins in IUGR placentas. Placentas from normal pregnant (NP; n = 18), PE (n = 18), and IUGR (n = 10) patients were investigated. Normotensive patients with IUGR delivered babies at >or= 37 wk of gestation with birth weights of <10% and asymmetrical growth. HIF-1 alpha, -2 alpha, Flt-1, and sFlt-1 protein, and mRNA were assessed by Western and Northern blot analyses, respectively. The results are expressed as ratios of the densitometric values for each pair of pathologic and normal placentas, a ratio of 1.0 indicating no difference. Comparable to our earlier studies, the PE/NP ratios for HIF-1 alpha, -2 alpha, and Flt proteins were significantly increased by 50-100% (all P < 0.01 vs. 1.0). Unexpectedly, the IUGR/NP ratios for HIF-1 alpha and -2 alpha proteins were 1.03 +/- 0.07 and 0.96 +/- 0.16, respectively, and for Flt and sFlt were 1.14 +/- 0.15 and 0.95 +/- 0.12, respectively (all P = not significant vs. 1.0). Northern blot analysis revealed comparable levels of HIF-alpha mRNA in abnormal and normal placentas. In contrast to PE, HIF-alpha proteins and regulated genes are not increased in placentas from normotensive pregnant women delivering small, asymmetrically grown babies >or= 37 wk of gestation. The absence of an increase in HIF-alpha protein is not due to insufficient HIF-alpha mRNA for protein synthesis. Thus, the placentas from women with PE and late IUGR are fundamentally different at the molecular level.

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Section: Discussionmentioning

confidence: 98%

Placental HIF-1α, HIF-2α, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction

Rajakumar

Jeyabalan

Marković

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…NIRS has since been utilized in various clinical fields all over the world (Mathieu & Mani 2007;Vardi & Nini 2008). We recently applied NIRS to the human placenta and successfully evaluated concentrations of oxyhemoglobin (HbO2) (Kakogawa et al 2005). Subsequently, we proposed a placental tissue oxygen index (TOI) as an index for the assessment of placental oxygenation (Kawamura et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Chorangiosis and placental oxygenation

Suzuki

Itoh

Kimura

et al. 2009

Congenital Anomalies

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Chorangiosis is a vascular hyperplasia in the terminal chorionic villi, usually diagnosed histologically using the criteria of Altshuler. Its true etiology has not been fully identified, but chorangiosis has been proposed to result from a longstanding, rather low-grade hypoxia in the placental tissue. To clarify a possible association of placental oxygenation status with the development of chorangiosis, we measured placental tissue oxygen index (TOI) values using near-infrared spectroscopy (NIRS) before delivery and retrospectively compared them to the detection of placental chorangiosis, in a total of 47 (46 singleton and one set of dichorionic diamniotic twins) pregnant women. Small for gestational age (SGA) and/or maternal complications were observed in all cases of placental chorangiosis. Placental TOI values were significantly elevated in cases of chorangiosis. This indicates high oxygen saturation in the intervillous spaces because placental TOI values are expected to represent the oxygenation of maternal blood in the placental tissue. A possible preceding low efficiency of oxygen transfer to the fetal circulation in the villi might not only augment the oxygen saturation of maternal blood in intervillous spaces, but also cause rather low oxygenation in the capillaries of the villi and result in chorangiosis.

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“…In addition, there are some drawbacks in that the probe can be dislocated as the fetal head descends during delivery. Ramanujam et al 9 and Kakogawa et al 10 found that fetal oxygen dynamics could be measured through the abdominal wall of the mother by NIRS.…”

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confidence: 99%

Measurement of Placental Oxygenation by Transabdominal Near-Infrared Spectroscopy

Kawamura

Kakogawa²,

Takeuchi³

et al. 2007

Amer J Perinatol

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The uteroplacental circulation in the placenta can have a major impact on the fetus. Near infrared spectroscopy (NIRS) is the noninvasive method of measuring changes in blood volumes and oxygen concentrations in living tissue. The purpose of this study is to monitor changes in placental tissue oxygen index (TOI) levels, in patients with intrauterine fetal growth restriction during pregnancy, using NIRS. We measured placental TOI values of 15 normal pregnant woman and 15 patients with intrauterine growth restriction admitted to our hospital. The placenta was assessed by ultrasound examination and NIRS was performed on all patients. The TOI values of the IUGR group when hospitalized was 78.6 +/- 1.6 (SD). This value was significantly higher than that of the controls (78.6 +/- 1.6 [SD] versus 70.2 +/- 0.4 [SD]). And the TOI values of the IUGR group, when measured before delivery, were 77.8 +/- 1.6 (SD). The TOI values of the IUGR group before delivery were significantly higher than those of the control group (77.8 +/- 1.6 [SD] versus 70.3 +/- 0.4 [SD]). We propose that NIRS is a candidate, noninvasive method for assessing placental oxygen dynamics on a real-time basis. In the near future it may contribute to perinatal medical practice.

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Transabdominal Measurement of Oxygenation of the Placenta by Near-Infrared Spectroscopy

Cited by 17 publications

References 1 publication

Placental HIF-1α, HIF-2α, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction

Placental HIF-1α, HIF-2α, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction

Chorangiosis and placental oxygenation

Measurement of Placental Oxygenation by Transabdominal Near-Infrared Spectroscopy

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