Transabdominal chorionic villus sampling for fetal genetic diagnosis. Technical and obstetrical evaluation of 100 cases

Smidt‐Jensen, Steen; Hahnemann, Niels

doi:10.1002/pd.1970080103

Cited by 28 publications

(6 citation statements)

References 15 publications

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“…TA-CVS can be considered an effective method for prenatal diagnosis allowing adequate chorionic tissue to be collected in nearly 100 per cent of cases during one session. The low incidence of short-term complications such as vaginal bleeding (1.5 per cent) has also been reported by others (Lilford et al, 1987;Brambati tit al., 1988;Smidt-Jensen and Hahnemann, 1988;Pijpers et al, 1988). When assessing the procedure-related fetal loss rate, the spontaneous abortion rate in women of advanced age should be considered.…”

Section: Discussionmentioning

confidence: 99%

Transabdominal villus sampling in early second trimester: A safe sampling method for women of advanced age

Jahoda¹,

Pijpers²,

Reuss³

et al. 1990

Prenatal Diagnosis

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Transabdominal chorionic villus sampling (TA-CVS) was performed in 707 viable singleton pregnancies to exclude chromosomal abnormalities. Maternal age ranged between 36 and 49 years (mean 37.9 years); gestational age varied between 10.2 and 18.3 weeks (mean 13.3 weeks). In 639 women (90.4 per cent), a sufficient amount of chorionic tissue (greater than or equal to 10 mg) was obtained after one needle insertion; in 66 women (9.3 per cent) two insertions were needed. An abnormal chromosome pattern was established in 19 cases (2.9 per cent). Vaginal bleeding or spotting within 28 days after TA-CVS occurred in 11 cases (1.5 per cent). The completed follow-up of 678 chromosomally normal pregnancies showed an overall fetal loss rate of 2.6 per cent before 28 weeks. The overall perinatal mortality was 0.9 per cent. When relating fetal loss to gestational age at TA-CVS, this was 6.6 per cent in women sampled before 12 weeks against only 1.8 per cent after 12 weeks. At the same time, the percentage of fetal loss occurring within 2 weeks following the procedure was 75 and 30 per cent, respectively. It is suggested that these data reflect the decline in spontaneous abortion rate during this particular period of pregnancy. It is concluded that TA-CVS is an effective procedure which, when performed after the natural decrease of fetal loss, appears to be a safe option for women of advanced maternal age.

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Section: Discussionmentioning

confidence: 99%

Transabdominal villus sampling in early second trimester: A safe sampling method for women of advanced age

Jahoda¹,

Pijpers²,

Reuss³

et al. 1990

Prenatal Diagnosis

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“…Thirdly, in our hands this sampling approach proved more rapid and simpler than transcervical aspiration (Brambati et al, 1987a). It is probably also quicker than transabdominal methods using a sterile needle-guided system (Smidt-Jensen and Hahnemann, 1988), and therefore it is appropriate for intensive CVS routine conditions, or when facilities for sterilizing the ultrasound system are not easily available.…”

Section: Discussionmentioning

confidence: 77%

Transabdominal chorionic villus sampling. Clinical experience of 1159 cases

1988

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The efficacy and risks of transabdominal free-hand ultrasound-guided fine needle aspiration technique were evaluated in 1159 pregnancies submitted to chorionic villus sampling (CVS) in the first trimester and early in the second trimester. An adequate amount of chorionic tissue was obtained by two needle insertions in 99.7 per cent of cases, and a second tapping was needed in 3.5 per cent of cases. A local peritoneal reaction was the only early complication clearly related to the procedure, and it occurred in 0.3 per cent of cases without any adverse effect on the maternal and fetal outcome. The correct abortion rate in 716 consecutive concluded pregnancies was 2.4 per cent, while the rate of late obstetrical complications and perinatal mortality and morbidity compares favourably with the rates in the general population. Because of its simplicity and practicability, transabdominal aspiration is the procedure of choice and is especially recommended for intensive CVS routine conditions.

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“…In our experience the overall success of transabdominal CVS was 97.5%. Smidt-Jensen and Hahnemann had a success of 84.5% in their earliest series:) though subsequently, they have been successful in all their cases.6) In the first half of the study the Weight of villus (9) No. of cases double needle aspiration technique proved easy to learn and we were able to obtain adequate samples with single insertion of the aspiration needle.…”

Section: Discussionmentioning

confidence: 96%

Current Method for First and Second Trimester Prenatal Diagnosis: Transabdominal Chorionic Villi Sampling

Buckshee

Parveen

Verma

1990

Asia-Oceania Journal of Obstetrics and Gynaecology

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Transabdominal CVS (chorionic villi sampling) was performed in 40 patients belonging to first or second trimester of pregnancy with 97.5% success, using a double and later single needle technique with no immediate complications. Karyotyping by direct method was successful in 75% of samples thus indicating the feasibility of cytogenetic analysis using villus tissue from first and second trimesters of pregnancy. It is a safe, simple, rapid and practical method of prenatal diagnosis in first and second trimesters of pregnancy with a potentially lower risk for fetal and maternal complications.

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Transabdominal chorionic villus sampling for fetal genetic diagnosis. Technical and obstetrical evaluation of 100 cases

Cited by 28 publications

References 15 publications

Transabdominal villus sampling in early second trimester: A safe sampling method for women of advanced age

Transabdominal villus sampling in early second trimester: A safe sampling method for women of advanced age

Transabdominal chorionic villus sampling. Clinical experience of 1159 cases

Current Method for First and Second Trimester Prenatal Diagnosis: Transabdominal Chorionic Villi Sampling

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