Transabdominal amnioinfusion in preterm premature rupture of membranes

Abstract

Transabdominal amnioinfusion reduced fetal distress, early neonatal sepsis, and neonatal mortality. In the study group, more participants delivered spontaneously and there were fewer cases of postpartum sepsis, although the pPROM-delivery interval was not increased.

Perinatal outcome in preterm premature rupture of membranes before 37 weeks of gestation

“…They concentrate on two topics: sealing the hole in membranes (amniopatch, immunologic sealants, membranes) and supplementing amniotic fluid (amnioinfusion). As of now, there is no answer to if any type of treatment improves pregnancy outcome [9,10].…”

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes

“…Benefits in the use of corticosteroids to accelerate fetal lung maturation and reduce the risk of necrotizing enterocolitis and intraventricular hemorrhage cases of PPROM over 24 0/7 weeks are also important [19,20]. On the other hand, there is not enough evidence of benefits of hospitalization, bed rest [21,22] or amnioinfusion in patients with previable PPROM [23][24][25]. In our department, diagnosis of PPROM involved the patient's hospitalization in order to facilitate early diagnosis of possible chorioamniotic infection.…”

Serial amnioinfusions prevent fetal pulmonary hypoplasia in a large animal model of oligohydramnios

“…Amnioinfusions have been done as early as 16 weeks in humans with a total of 4 amnioinfusions spaced 4 weeks apart for preterm pPROM resulting in healthy, fullterm infants without any subsequent complications [12]. Others have confirmed, even in the setting of pPROM, amnioinfusions to be beneficial in reducing fetal distress, neonatal sepsis, and mortality [13]. Amnioinfusions have been done for multiple etiologies of oligohydramnios and speak to the need for a novel way to reduce the current invasive nature of repeatedly accessing the amniotic cavity each time.…”

“…This may also be true if the amniotic fluid and cavity are reconstituted to a similar environment the fetus would have encountered if not for the obstructive uropathy. Serial amnioinfusions have been used for treating oligohydramnios owing to a variety of etiologies [3,6,[12][13][14][15] but not with an implanted intrauterine catheter. We sought to examine the feasibility and utility of administering serial amnioinfusions through a tunneled implanted intrauterine catheter to prevent pulmonary hypoplasia in the setting of congenital obstructive uropathy.…”