“…1,4-Dideoxy-1,4-imino- d -arabinitol ( 1 , DAB) is among the most studied iminosugars due to its widespread isolation from various sources 1–3 and significant glycosidase inhibition. The trihydroxylated pyrrolidine shows potent inhibition against yeast α-glucosidase, 2,4–9 rat intestinal sucrase, 9 α,α-trehalase 9,10 and glycogen phosphorylase, 11 and is also found to be a moderate or weak inhibitor of a series of α-glucosidases from various sources, 9,10,12 β-glucosidase, 10,12 α-mannosidase 10,12 and amyloglucosidase. 12 In contrast, many naturally occurring and synthetic derivatives of DAB have been found with the tendency of narrowing down their inhibition spectra.…”