Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters

Freitas, Juliana Vescovi de; Praça, Fabíola Silva Garcia; Bentley, Maria Vitória Lopes Badra; Gaspar, Lorena Rigo

doi:10.1016/j.ijpharm.2015.02.062

Cited by 64 publications

(53 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The choice of stratum corneum-epidermis membrane instead of full thickness skin was justified since the dermis could act as a further barrier to permeation, distorting in vitro evidence [7]. Analysis of recent literature shows an increasing use of porcine skin with respect to the past [5,14,16,23]. Most of the studies employed the outer surface of freshly excised pig ears, after hair and underlying cartilage removal.…”

Section: In Vitro Methodsmentioning

confidence: 99%

“…The booster effect on the body natural reserve of antioxidants can contribute to neutralization of intrinsic and extrinsic ROS, creating a new kind of sunscreen with a two-step protection: The first operated by UV-filters as a "passive" protection by absorbing and reflecting UV radiation and the second as "active" protection by antioxidants quenching ROS generated by UV light that has by-passed UV filters [4]. Differently from synthetic UV-filters, which have to remain on the stratum corneum to be safe and effective, natural compounds should reach the viable skin layers to exploit photo-protection effect, since ultraviolet radiation penetrates deeply the skin [16].…”

Section: Natural Compoundsmentioning

confidence: 99%

“…Indeed, both molecular weight and lipophilicity of the molecule play an important role in cutaneous penetration, as well as it has been demonstrated that skin permeation and retention from topical products can differ significantly among the formulations used [16,17].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

et al. 2017

View full text Add to dashboard Cite

Sunscreens are the most common products used for skin protection against the harmful effects of ultraviolet radiation. However, as frequent application is recommended, the use of large amount of sunscreens could reflect in possible systemic absorption and since these preparations are often applied on large skin areas, even low penetration rates can cause a significant amount of sunscreen to enter the body. An ideal sunscreen should have a high substantivity and should neither penetrate the viable epidermis, the dermis and the systemic circulation, nor in hair follicle. The research of methods to assess the degree of penetration of solar filters into the skin is nowadays even more important than in the past, due to the widespread use of nanomaterials and the new discoveries in cosmetic formulation technology. In the present paper, different in vitro studies, published in the last five years, have been reviewed, in order to focus the attention on the different methodological approaches employed to effectively assess the skin permeation and retention of sunscreens.

show abstract

Section: In Vitro Methodsmentioning

confidence: 99%

Section: Natural Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Organic (synthetic) and mineral UV filters pose relevant challenges related to their photo-stability in vitro and in vivo under UV irradiation [81,82], their homogeneous distribution onto the skin [83][84][85], and their capability to reach the viable layers of epidermis and obtain sufficient accumulation in the stratum corneum [86] while also avoiding their systemic penetration due to the widespread concerns on their toxicity [87]. A major role is played by vehicles, which undergo a continuous technological evolution in the highly competitive cosmetic world, moving from the traditional vaseline or oil-in-water (o/w) emulsion delivery systems.…”

Section: Formulation Of Sun Protective Cosmetics Based On Secondary Pmentioning

confidence: 99%

“…More effective increase of synthetic UV-filters safety has been recently achieved with the co-formulation of beta-carotene and resveratrol. These plant-derived SPMs inhibited deep transcutaneous penetration of synthetic UV filters and prolonged their accumulation in the stratum corneum [87]. This may represent a feasible approach to the reduction of repeated sunscreen applications to ensure sunscreen compliance [106].…”

Section: Formulation Of Sun Protective Cosmetics Based On Secondary Pmentioning

confidence: 99%

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Korkina¹,

Kostyuk

Potapovich

et al. 2018

Cosmetics

View full text Add to dashboard Cite

Topical sun protective cosmetics (sunscreens, pre-and post-sun) have been intensively developed and produced to protect human skin against solar irradiation-associated damages/pathologies. Unfortunately, routine cosmetics for sun protection containing synthetic organic and/or physical sunscreens could exert adverse effects towards human organisms and bring undesirable ecological changes. Terrestrial and marine plant species, being exposed to sun light for hundreds of millions of years, have evolved two pro-survival strategies: effective protection against/adaptation to its deleterious effects and the use of solar energy for photosynthesis/photo-biochemical reactions. Secondary plant metabolites (SPM) are primary sensors of solar energy and mediators of its use (photo-sensitisers) or neutralisation (photo-protectors). A similar double photo-protective/photo-sensitising system is built in within human skin. Modern development of toxicologically/ecologically safe yet effective sun-protective cosmetics attempts to pre-select photo-stable and non-phototoxic SPMs that provide broad UVA + UVB sunscreen, free radical scavenging and direct antioxidant defence, endogenous antioxidant rescue, induction of antioxidant enzymes (indirect antioxidant defence), and normalisation of metabolic and immune responses to UVA + UVB. Proper formulation of sun protective cosmetics should assure targeted delivery of photo-active SPMs to definite skin layers to invigorate the built in photo-chemical skin barrier.

show abstract

Microalgae‐Derived Health Supplements to Therapeutic Shifts: Redox‐Based Study Opportunities with AIE‐Based Technologies

Reza

Zhu

Qin

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are highly reactive molecules, serve the normal signaling in different cell types. Targeting ROS as the chemical signals, different stress based strategies have been developed to synthesis different anti‐inflammatory molecules in microalgae. These molecules could be utilized as health supplements in human. To provoke the ROS‐mediated defence systems, their connotation with the associated conditions must be well understood, therefore, proper tools for studying ROS in natural state are essential. The in vivo detection of ROS with phosphorescent probes offers promising opportunities to study these molecules in a non‐invasive manner. Most of the common problems in the traditional fluorescent probes are lower photostability, excitation intensity, slow responsiveness, and the microenvironment that challenge their performance. Some ROS‐specific aggregationinduced emission luminogens (AIEgens) with pronounced spatial and temporal resolution have recently demonstrated high selectivity, rapid responsiveness, and efficacies to resolve the aggregation‐caused quenching issues. The nanocomposites of some AIE‐photosensitizers can also improve the ROS‐mediated photodynamic therapy. These AIEgens could be used to induce bioactive components in microalgae through altering the ROS signaling, therefore are more auspicious for biomedical research. This study reviews the prospects of AIEgen‐based technologies to understand the ROS mediated bio‐physiological processes in microalgae for better healthcare benefits.

show abstract

Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters

Cited by 64 publications

References 58 publications

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Microalgae‐Derived Health Supplements to Therapeutic Shifts: Redox‐Based Study Opportunities with AIE‐Based Technologies

Contact Info

Product

Resources

About