2008
DOI: 10.1364/oe.16.017484
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Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate, Part I: Simulation

Abstract: We investigate the feasibility of trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator that is to be integrated with a trans-rectal ultrasound (TRUS) probe. Integration with TRUS ensures accurate endo-rectal positioning of the NIR applicator and the utility of using TRUS spatial prior information to guide NIR image reconstruction. The prostate NIR image reconstruction is challenging even with the use of spatial prior owing to the anatomic complexity of the imaging… Show more

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Cited by 44 publications
(39 citation statements)
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“…The experimentally tested configuration was originally designed for whole prostate imaging [23][24][25]. With its large field of view, lesion monitoring is relatively insensitive to probe placement.…”
Section: Optimal Clinical Configurationmentioning
confidence: 99%
See 2 more Smart Citations
“…The experimentally tested configuration was originally designed for whole prostate imaging [23][24][25]. With its large field of view, lesion monitoring is relatively insensitive to probe placement.…”
Section: Optimal Clinical Configurationmentioning
confidence: 99%
“…A variety of DOT systems have been reported for functional imaging or tumor detection, including in the breast [18][19][20] and brain [21,22]. Of particular relevance here is a system that combined continuous-wave (CW) transrectal diffuse optical tomography (CW-TRDOT) with twodimensional (2-D) TRUS for prostate cancer detection and quantification, based on the tumor having higher optical absorption than normal prostate in the NIR [23][24][25]. Tumor imaging was successfully demonstrated in a canine prostate cancer model [24] using this system.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…As in [Schweiger and Arridge, 1999b], by restricting all pixels in the optical domain belonging to the same tissue type to be completely correlated, the underdetermined problem of DOT becomes overdetermined as the number of unknowns drops dramatically. Jiang et al [2008]; Xu et al [2008] used the method to incorporate prior information in trans-rectal ultrasound imaging (UI) driver, DOT imaging. Pogue and Paulsen [1998] used the information from a segmented coronal MRI slice acquired from a rat, in order to create a realistic finite element mesh based numerical phantom to be probed.…”
Section: Hard Constraints and Other Types Of Prior Informationmentioning
confidence: 99%
“…This technique has been investigated for several clinical applications, particularly for monitoring of functional brain activities [3][4][5] and detection of breast cancer [6,7]. The fundamental principle of DOT is that the detected NIR signals reflect optical properties of the underlying biological tissues [8,9] and that the spatial distribution of such measured optical properties can be used to reconstruct optical tomographic images.…”
Section: Introductionmentioning
confidence: 99%