Trans-Lycopene and β-Cryptoxanthin Intake and Stomach Cancer in Vietnamese Men: A Pilot Case-Control Study

Sengngam, Khanpaseuth; Học, Trần Hiếu; Hang, Dao Viet; Le, Ngoan Tran

doi:10.31557/apjcp.2022.23.3.861

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…With regard to cancers of the digestive system, lycopene intake showed a strong protective effect against stomach cancer, regardless of H. pylori status [ 82 ]. The mechanism of lycopene benefits in animal models of gastric and oesophageal cancer is based on modulation of carcinogen-induced tumour cell proliferation and apoptosis and enhancement of antioxidant and immune activities in the cancer microenvironment [ 71 , 72 , 73 , 81 , 83 , 93 ].…”

Section: Resultsmentioning

confidence: 99%

The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies

2022

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Lycopene is a nutraceutical with health-promoting and anti-cancer activities, but due to a lack of evidence, there are no recommendations regarding its use and dosage. This review aimed to evaluate the benefits of lycopene supplementation in cancer prevention and treatment based on the results of in vivo studies. We identified 72 human and animal studies that were then analysed for endpoints such as cancer incidence, improvement in treatment outcomes, and the mechanisms of lycopene action. We concluded that the results of most of the reviewed in vivo studies confirmed the anti-cancer activities of lycopene. Most of the studies concerned prostate cancer, reflecting the number of in vitro studies. The reported mechanisms of lycopene action in vivo included regulation of oxidative and inflammatory processes, induction of apoptosis, and inhibition of cell division, angiogenesis, and metastasis formation. The predominance of particular mechanisms seemed to depend on tumour organ localisation and the local storage capacity of lycopene. Finally, there is a need to look for predictive factors to identify a population that may benefit from lycopene supplementation. The potential candidates appear to be race, single nucleotide polymorphisms in carotene-cleaving enzymes, some genetic abbreviations, and insulin-like growth factor-dependent and inflammatory diseases.

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Section: Resultsmentioning

confidence: 99%

The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies

2022

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“…Criteria for selecting patients included being indicated for surgery when physically healthy enough to endure the surgery, good communication, histopathology tests showing cancer, and agreeing to participate in the study. Exclusion criteria were when the patient refused to participate, unable to communicate, in poor physical condition and had a diet change due to illness, or was on a diet due to their health status (Nguyen et al, 2022a(Nguyen et al, , 2023Sengngam et al, 2022).…”

Section: Cases Recruitmentmentioning

confidence: 99%

“…Criteria for selecting controls were not having cancer currently or in the past, good communication, and agreeing to participate in the study. Exclusion criteria included refusal, change in diet due to health or illness, and relatively stable health condition that can withstand the planned surgery (Nguyen et al, 2022a(Nguyen et al, , 2023Sengngam et al, 2022).…”

Section: Controls Recruitmentmentioning

confidence: 99%

Tryptophan intake and pancreatic cancer: findings from a case-control study

Luu,

Pham,

Yuan

et al. 2024

European Journal of Cancer Prevention

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Background Pancreatic cancer is a leading cause of cancer-related death worldwide. Tryptophan plays a vital role in cell growth and maintenance as a building block of protein and coordination of organismal responses to environmental and dietary cues. Animal model study showed that dietary tryptophan improved treatment response in those who received chemotherapy or immune checkpoint inhibitors. Limited data are available assessing the association between tryptophan intake and risk of pancreatic cancer. We aimed to evaluate this association in a case-control study in Vietnam. Methods We analyzed data from a case-control study, including 3759 cancer cases and 2995 control subjects of whom 37 with pancreatic cancer cases. Tryptophan intake was derived from food frequency questionnaire. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for different levels of tryptophan intake with pancreatic cancer risk. Results Overall, tryptophan intake was inversely associated with pancreatic cancer risk in a dose-dependent manner. The ORs and 95% CIs of pancreatic cancer were 0.51 (0.29–0.92) for continuous scale, 0.27 (0.10–0.73) for tertile 2 and 0.34 (0.11–1.06) for tertile 3, compared with tertile 1 (the lowest intake) (P trend = 0.02). In stratified analysis, this inverse association pattern was present among those with BMI < 23 kg/m2 and ever drinkers. Conclusion A diet with a higher intake of tryptophan was significantly associated with a lower incidence of pancreatic cancer among Vietnamese population. These suggest that dietary modification may be an effective strategy for primary prevention of pancreatic cancer development.

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“…β-cryptoxanthin has shown its potential in various cancers, including stomach cancer ( Sengngam et al., 2022 ), hepatocellular carcinoma ( Lim et al., 2020 ), lung cancer ( Iskandar et al., 2016 ), and colon cancer ( San Millan et al., 2015 ). Lutein was reportedly having strong anticancer potential against breast cancer ( Bulatao et al., 2023 ), non-small cell lung cancer ( Zhang et al., 2023 ), pancreatic cancer ( Han and Song, 2022 ), and gastric cancer ( Eom et al., 2023 ).…”

Section: Phytochemicals Present In O Ficus-indica ...mentioning

confidence: 99%

Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives

Wang,

Rani,

Jakhar

et al. 2023

Front. Plant Sci.

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Cancer is a leading cause of mortality worldwide, and conventional cancer therapies such as chemotherapy and radiotherapy often result in undesirable and adverse effects. Natural products have emerged as a promising alternative for cancer treatment, with comparatively fewer side effects reported. Opuntia ficus-indica (L.) Mill., a member of the Cactaceae family, contains a diverse array of phytochemicals, including flavonoids, polyphenols, betalains, and tannins, which have been shown to exhibit potent anticancer properties. Various parts of the Opuntia plant, including the fruits, stems/cladodes, and roots, have demonstrated cytotoxic effects against malignant cell lines in numerous studies. This review comprehensively summarizes the anticancer attributes of the phytochemicals found in Opuntia ficus-indica (L.) Mill., highlighting their potential as natural cancer prevention and treatment agents. Bibliometric metric analysis of PubMed and Scopus-retrieved data using VOSviewer as well as QDA analysis provide further insights and niche to be explored. Most anticancer studies on Opuntia ficus-indica and its purified metabolites are related to colorectal/colon cancer, followed by melanoma and breast cancer. Very little attention has been paid to leukemia, thyroid, endometrial, liver, and prostate cancer, and it could be considered an opportunity for researchers to explore O. ficus-indica and its metabolites against these cancers. The most notable mechanisms expressed and validated in those studies are apoptosis, cell cycle arrest (G0/G1 and G2/M), Bcl-2 modulation, antiproliferative, oxidative stress-mediated mechanisms, and cytochrome c. We have also observed that cladodes and fruits of O. ficus-indica have been more studied than other plant parts, which again opens the opportunity for the researchers to explore. Further, cell line-based studies dominated, and very few studies were related to animal-based experiments. The Zebrafish model is another platform to explore. However, it seems like more in-depth studies are required to ascertain clinical utility of this biosustainable resource O. ficus-indica.

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Trans-Lycopene and β-Cryptoxanthin Intake and Stomach Cancer in Vietnamese Men: A Pilot Case-Control Study

Cited by 6 publications

References 5 publications

The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies

The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies

Tryptophan intake and pancreatic cancer: findings from a case-control study

Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives

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